Preparation method and use of medicinal pregelatinized hydroxypropyl starch

Abstract

The invention relates to the technical fields of starch production, and particularly relates to medicinal pregelatinized hydroxypropyl starch and a preparation method and use of the medicinal pregelatinized hydroxypropyl starch. The preparation method comprises the following steps: 1 pretreatment and activation of starch; 2 synthesis of hydroxypropyl starch; 3 refining of the hydroxypropyl starch; and 4 preparation and refining of pregelatinized hydroxypropyl starch. The pregelatinized hydroxypropyl starch obtained by the method is high in content of effective components, and low in impurity content; the microbial limit is controlled; and the solubleness and the freeze-thaw stability of the pregelatinized hydroxypropyl starch in cold water are greatly improved, thus achieving the medicinal grade standards.

Description

technical field [0001] The invention belongs to the field of starch modification and relates to a modified starch, in particular to a preparation method and application of medicinal pregelatinized hydroxypropyl starch. Background technique [0002] Starch is one of the most productive natural polymers in nature, and it is the main carbohydrate component of higher plants, which has a very wide range of industrial uses. For example, in the food industry, starch is used, among other things, as a texture improver, gelling agent, thickener and stabilizer. In the paper industry, starch is used as a binder to improve printability, surface strength and solvent resistance. In the field of materials, starch can be used as a raw material for the preparation of a variety of new degradable materials for the manufacture of pharmaceuticals, cosmetics, plastics, dyes and other commonly used products. Therefore, in order to undertake these roles, certain special properties such as solubili...

AI Technical Summary

Problems solved by technology

But adopt the method of this patent to have following problem: 1, the basic catalyst that adopts is sodium hydroxide or potassium hydroxide, and its consumption is 12-20% of starch weight, strong basic material can not only accelerate the development of propylene oxide Ring reaction, but also accelerate the formation of by-products, such as propylene glycol, etc.

2. The amount of strong alkaline substances needed to be used in the whole reaction process is also relatively large, such as swelling agent and catalyst are strong alkali, so the corrosion of equipment and the impact on the environment are also worrying

3. Since the reaction is carried out under non-airtight conditions, and the propylene oxide and the dispersion medium isopropanol are both volatile substances, simple condensation and reflux will still cause certain losses

The composite modified starch of this invention makes up for some deficiencies in the performance of existing modified starches, and has stable product quality, suitable viscosity, high reaction efficiency, energy saving and environmental protection; however, the quadruple modification in this method is actually a "one-pot" method It is easy to cause inhomogeneous mixing of starch and modifying agent, so that the degree of reaction is uncontrollable, and the degree of substitution of each substituent group will also have certain differences, so it is impossible to ensure that the compound modified starch product with stable degree of substitution can be obtained regularly, which will inevitably lead to Uncertain effects on various physical and chemical properties of the product, resulting in different performances of products produced in different batches, and the difference is obvious

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