Echinacea purpurea root granule, its preparation method and its application in the preparation of swine and chicken vaccine immune enhancer

Abstract

The invention belongs to the field of vegetable drug products and discloses echinacea purpurea (L.) Moench root granules as well as a preparation method and application thereof. The content of chicoric acids in the echinacea purpurea (L.) Moench root granules is 5-25mg / g. The preparation method comprises the following steps: grinding the drug materials, namely echinacea purpurea (L.) Moench roots and sieving the ground echinacea purpurea (L.) Moench roots to obtain echinacea purpurea (L.) Moench root powder; mixing the echinacea purpurea (L.) Moench root powder with an ethanol solution with percentage concentration by weight of 50-80% to soak the echinacea purpurea (L.) Moench root powder, carrying out ultrasonic extraction twice, filtering the extracts and collecting the filtrate and the residues; mixing the residues with an ethanol solution with percentage concentration by weight of 10-30%, carrying out ultrasonic extraction once, filtering the extract, collecting the filtrate and combining the filtrates; recovering ethanol from the filtrate at reduced pressure and concentrating ethanol; spray-drying the concentrated solution to obtain extract powder; mixing the extract powder with an auxiliary material and granulating the mixture; carrying out fluid bed drying, powder sieving and filling, thus obtaining the echinacea purpurea (L.) Moench root granules. The echinacea purpurea (L.) Moench root granules can obviously enhance the immune effects of Newcastle disease vaccines and porcine reproductive and respiratory syndrome vaccines.

Description

technical field [0001] The invention belongs to the field of herbal medicines, and in particular relates to an echinacea purpurea root granule, a preparation method thereof and an application in preparing pig and chicken vaccine immune enhancers. Background technique [0002] Due to various management reasons, modern large-scale breeding leads to low animal immunity, which reduces the performance of breeding production and is prone to diseases, which brings huge economic loss to the breeding industry. Immunity enhancers can improve the immunity of animals and improve disease resistance. Ability, used together with vaccines, can enhance the immune response of the body to vaccines, the level of protective immunity can be reached in advance, and the antibody titer can be significantly improved. Used together with antiviral drugs and antibacterial drugs, it can enhance the ability of antiviral drugs and antibacterial drugs to kill pathogens. [0003] The root of Echinacea purpur...

AI Technical Summary

Problems solved by technology

[0003] The root of Echinacea purpurea is the root and rhizome of Echinacea pupurea (L.) Moench, a perennial herb of the genus Echinacea in the family Asteraceae. It has strong immune strengthening and anti-inflammatory effects. At present, the dosage form of Echinacea purpurea root in veterinary medicine includes Echinacea pupurea root powder, which is a powder. The powder is only used for mixed feeding and cannot be administered with drinking water. It is inconvenient to use. The active ingredients are in the plant cells and need to be digested and dissolved before being absorbed by animals. However, the digestive tract of animals is short, and some drugs are excreted without being absorbed. , causing waste, the bioavailability of active ingredients in Echinacea purpurea root is relatively low, it is inconvenient to use, and the effect is slow

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