Bone repair material and preparation and use method thereof

Abstract

Provided are a bone repair material and a preparation and use method thereof. The bone repair material is composed of a strontium compound and alpha-calcium sulfate hemihydrate. The molar weight of strontium occupies 0.1-10% of the total molar weight of calcium and the strontium. The preparation method includes 1) utilizing a co-precipitation method to prepare strontium CaSO4.2H2O and 2) utilizing a hydrothermal method to prepare strontium CaSO4.0.5H2O. Compared with the prior art, the bone repair material has the advantage that the bone repair material can serve as a bone filling material which is better in quality, degradable and good in bioactivity, can promote bone repair and can serve as an application of a drug delivery system.

Description

Technical field: [0001] The present invention relates to a biological material and methods for its preparation and use. Background technique: [0002] The causes of bone defects in orthopedic clinical work are various, such as bone tumor and osteomyelitis resection, deformity correction and trauma. In addition, since the metaphysis of long bones is mostly cancellous bone, bone defects can also be caused after compression fractures, and most of them involve the articular surface, which will significantly affect the joint function. At present, the gold standard for the treatment of bone defects is still autologous bone grafting, but autologous bone grafting has the disadvantages of limited sources and the need for additional surgical trauma. Therefore, autologous bone grafting is not realistic for bone defects with large bone mass. Allogeneic bone is prone to immune rejection because of the body, while allogeneic bone has the disadvantage of poor biocompatibility, so its clin...

AI Technical Summary

Problems solved by technology

The development of strontium-containing materials is also increasing. Chinese invention patent 200810301291.2 prepares new materials by mechanically mixing α-calcium sulfate hemihydrate and strontium-containing compounds. The disadvantage is that it is difficult to ensure the uniformity of each component

However, in Chinese invention patent 201110257822.4, after preparing calcium sulfate dihydrate containing strontium, it is directly heat-treated at 150°C-170°C. Insufficient strength for clinical use