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Emulsifiable paste composed of western medicines for treating pressure sores and preparation method of emulsifiable paste

A composition and technology for pressure ulcers, applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients, etc., can solve the problems of inability to rapidly heal wounds by muscle regeneration, damage to new granulation tissue, and unsatisfactory clinical efficacy, etc. Skin tissue heals and repairs quickly, promotes the formation of granulation tissue and epithelial tissue, and has good antibacterial, anti-inflammatory and analgesic effects.

Inactive Publication Date: 2014-12-10
冷敏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the clinical treatment is mainly antibacterial and anti-inflammatory to prevent secondary infection. However, these drugs are highly irritating to the wound, and they are easy to damage the new granulation tissue when changing the dressing, which is not conducive to the healing of the wound, so it cannot quickly heal the wound with muscle growth , so the clinical efficacy is not ideal
Up to now, there is no comparatively ideal treatment medicine and method both at home and abroad.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A western medicine composition for treating pressure sores, which is composed of dexamethasone acetate, claritan and ofloxacin, and the mass ratio of the three is 0.8:1:18.2.

Embodiment 2

[0034] A western medicine composition for treating pressure sores, which consists of dexamethasone acetate, claritan and ofloxacin, and the mass ratio of the three is 1.6:2.4:16.

Embodiment 3

[0036] A kind of emulsifiable ointment for treating pressure sore, is made up of following components: glycerin 180g, ethylparaben 2g, dexamethasone acetate 0.8g, claritan 1g, ofloxacin 18.2g, stearic acid 100g, stearyl alcohol 50g, 1g of 2,6-di-tert-butyl-p-cresol, 10g of laurocaprolactone, 80g of liquid paraffin, 15g of triethanolamine, and the balance is water. Flufloxacin is a drug component, wherein dexamethasone acetate, claritan and ofloxacin are drug components.

[0037] Prepare as follows:

[0038] (1) Water phase preparation: add glycerin, ethylparaben, dexamethasone acetate, claritan and ofloxacin to water, heat to 65°C, stir well, and set aside;

[0039] (2) Oil phase preparation: mix stearic acid, stearyl alcohol, 2,6-di-tert-butyl-p-cresol, laurocaprazine and liquid paraffin, heat to 80°C, stir well, and set aside;

[0040] (3) Stirring and mixing: add the oil phase to the water phase under stirring, then add triethanolamine, and stir while adding. When the tem...

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PUM

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Abstract

The invention belongs to the field of medical pharmacy, and in particular relates to an emulsifiable paste composed of western medicines for treating pressure sores and a preparation method of the emulsifiable paste. The emulsifiable paste is characterized by taking dexamethasone acetate, clarityne and ofloxacin as medical ingredients. The emulsifiable paste is composed of the following ingredients: 50g to 230g of glycerin, 0g to 2g of ethyl salicylate, 0.8g to 1.6g of dexamethasone acetate, 1g to 2.4g of clarityne, 16g to 18.2g of ofloxacin, 50g to 120g of stearic acid, 30g to 75g of octadecanol, 0g to 1g of 2,6-Di-tert-butyl-p-cresol, 0g to 12g of laurocapram, 60g to 120g of liquid paraffin, 4g to 20g of triethanolamine and the balance of water, wherein the sum of the content of all the ingredients is 1000g; the ingredients are prepared into an O / W type emulsifiable paste or a W / O type emulsifiable paste. The emulsifiable paste has the advantages that (1) the emulsifiable paste is scientific and reasonable in formula and has a rapid therapeutic effect on the pressure sores; (2) the emulsifiable paste is good in antibacterial, anti-inflammatory and analgesic effects, high in water retention rate and good in breaking and tearing strength, and is capable of preventing seepage from overflowing and promoting the formation of granulation tissues and epithelial tissues so as to achieve the effects of rapid skin tissue healing and repair; (3) the emulsifiable paste is good in performance, low in cost and convenient to use.

Description

technical field [0001] The invention belongs to the field of medicine and pharmacy, and in particular relates to a western medicine composition for treating pressure sores, a cream and a preparation method of the cream. Background technique [0002] Pressure sores are also known as "decubitus ulcers" or "pressure ulcers". Pressure sore refers to long-term pressure on a part of the body, which hinders blood circulation and causes blisters, ulcers or necrosis of the skin and subcutaneous tissue due to ischemia. In short, pressure sores are the end result of nutrient blood supply and blood flow disturbance in body tissues. [0003] Pressure sores often occur in patients who are paralyzed due to illness, have been bedridden for a long time, have physical failure, have been bedridden for a long time, have improper nursing care, are inconvenient to turn over and move, and have sensory disturbances in their limbs. Excessive weight loss, excessive obesity, edema, and arteriosclero...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61K9/06A61P17/02A61K31/5383A61K31/4545
Inventor 冷敏韩臻曹国荣窦超
Owner 冷敏
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