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Application of pharmaceutical compositions in treatment of eczematous dermatitis

A technology for dermatitis and eczema and a composition is applied in the application field of preparation, prevention and treatment of dermatitis and eczema, and can solve the problems that patients are not suitable for use and maintain medication for a long time.

Active Publication Date: 2014-11-26
施惠娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(7) Others: tranilast, glycyrrhizic acid, and multivitamins can be used in the treatment of dermatitis and eczema, and interferon-γ can be used as an adjuvant therapy. It may be effective in the treatment of dermatitis and eczema, but often requires long-term maintenance medication
[0005] Matrine is a powerful anti-inflammatory drug with hormone-like effects and no hormone side effects. Studies have shown that it mainly inhibits leukocyte migration, stabilizes lysosomal membranes, promotes free radical scavenging, and inhibits the synthesis of inflammatory mediators such as histamine and lymphokines. Or the release and inhibition of inflammatory activity; oxymatrine has a strong immune regulation effect, and can exert its anti-inflammatory effect through the influence of the host's antibody level, immune cell changes, cytokines and other inflammatory regulatory factors; However, the effective extract of Sophora flavescens or matrine has side effects such as diuresis and natriuresis in clinical practice, so patients with excessive urine output should not use it.
Glycyrrhizic acid has anti-inflammatory, anti-allergic, anti-viral, and liver-protecting effects, but the steroid-like effect of glycyrrhizic acid, long-term oral administration of active ingredient extracts of licorice or glycyrrhizic acid and its derivatives will cause patients to have water and sodium retention, Serious adverse reactions such as hypertension and hypokalemia

Method used

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  • Application of pharmaceutical compositions in treatment of eczematous dermatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Comparison of acute toxic effects of oxymatrine, glycyrrhizic acid and their compositions on mice

[0026] Kunming mice were randomly divided into a normal control group and a test drug group, with ten mice in each group, half male and half male. In addition to the normal control group, the test drug group was injected intraperitoneally (ip) with a large dose of oxymatrine, glycyrrhizin and the combination of the two components once, and the animals were observed continuously for 7 days, and the death time and number of animals were recorded.

[0027] The results showed that when the dose of oxymatrine was 950mg / kg, it had great toxicity, and 9 of the 10 mice died; when the dose of glycyrrhizin was 950mg / kg, 2 of the 10 mice died, while the oxidized Kushen minus: glycyrrhizin ratio 1:1 and combined dose of 950mg / kg and matrine: glycyrrhizin ratio of 2:1 and combined dosage of 950mg / kg, no animals died, oxidized matrine reduced: glycyrrhizin When the ratio of oxymatri...

Embodiment 2

[0031] Observation on the curative effect of compound glycyrrhizin combined with oxymatrine in the treatment of generalized eczema

[0032] 1 Materials and methods

[0033] 1.1 Clinical data The clinical diagnosis is consistent with patients with generalized eczema. The clinical diagnosis is consistent with acute eczema, subacute eczema or acute exacerbation of chronic eczema in 40 patients, 20 males and 20 females. After treatment, no serious visceral diseases such as liver and kidney dysfunction, no history of active tuberculosis, hypertension, diabetes, and cataract, and pregnant and lactating women were excluded. The patients were randomly divided into four groups: oxymatrine treatment group (group A), compound glycyrrhizin treatment group (group B), oxymatrine combined with compound glycyrrhizin treatment group (group C), and control group (group D). group), ten cases in each group, half male and half male. There was no statistical difference among the four groups in ...

Embodiment 3

[0045] Oxymatrine 200mg

[0046] Diammonium Glycyrrhizinate 150mg

[0047] NaCl 0.9g

[0048] Appropriate amount of water for injection

[0049] 100ml each

[0050] Take NaCl, stir and dissolve with water for injection, then add oxymatrine and diammonium glycyrrhizinate respectively, dissolve completely while continuing to stir, add water for injection to the total amount, filter until clear, seal in a pot, and sterilize to obtain the product.

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Abstract

Disclosed are a pharmaceutical composition comprising kushenin and glycyrrhizic acid or derivatives thereof and the use of the composition in preparing a drug for preventing and treating dermatitis and eczema, wherein the weight ratio of the kushenin or a derivative thereof to the glycyrrhizic acid or a derivative thereof is 10:1-1:10.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of a pharmaceutical composition in the preparation of prevention and treatment of dermatitis and eczema. The pharmaceutical composition contains matrine (oxymatrine, matrine, isomatrine) and glycyrrhizic acid or a pharmaceutically acceptable form of the two or derivatives of the two and the composition containing these The medicine box also includes glycyrrhizic acid matrine salt and glycyrrhizic acid matrine salt. Background technique [0002] As we all know, dermatitis and eczema skin diseases are common diseases in dermatology. The etiology and pathogenesis of dermatitis and eczema are not yet clear. The etiology is quite complicated, and most of them are caused by allergies. It is an allergic reaction caused by the interaction of various internal and external factors. But some dermatitis eczema has nothing to do with allergy. Changes in patient responsiveness often inv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P17/00A61P25/00A61P37/08A61P17/08A61P17/04A61K31/4375
CPCA61K9/0019A61K9/2054A61K9/2059A61K31/4545A61K31/704A61P17/00A61P17/04A61P17/08A61P25/00A61P37/08A61K2300/00
Inventor 施惠娟
Owner 施惠娟
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