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Digestive tract mucous membrane restoration promotion material, and preparation method and use thereof

A technology for repairing materials and digestive tracts, applied in medical science, surgery, etc., can solve the problems of low friction coefficient, easy premature degradation, loss of function, etc., and achieve the effect of excellent mechanical properties, no cytotoxicity, and safe use

Active Publication Date: 2014-10-22
TOPREGMED BEIJING MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some obvious defects in using SIS as a repair material for the digestive tract mucosa, such as being easily deformed in contact with water, easily degraded by strong acid and pepsin, and having a low coefficient of friction, which makes it difficult to transport SIS endoscopically and is easy to reach the lesion. Loss of function due to premature degradation

Method used

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  • Digestive tract mucous membrane restoration promotion material, and preparation method and use thereof
  • Digestive tract mucous membrane restoration promotion material, and preparation method and use thereof
  • Digestive tract mucous membrane restoration promotion material, and preparation method and use thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment 1 The preparation of the material for promoting the repair of digestive tract mucosa of the present invention

[0054] 1. The preparation of the material for promoting digestive tract mucosa repair of the present invention

[0055] 1. Preparation of SIS

[0056] The SIS of the present invention can be purchased as a commercial product, or can be prepared according to the following method.

[0057] (1) Cleaning and finishing: take the fresh pig small intestine half an hour after slaughter, wash away the contents of the small intestine with water, turn over the small intestine, add salt and rub it, rinse it repeatedly with water for 3 times, cut open the small intestine with a scalpel, and then cut it into 15 cm long of the intestinal segment.

[0058] (2) Isolate the SIS: scrape off the muscular layer and serosa layer with a tongue depressor, and store in normal saline at 4°C overnight.

[0059] (3) Degreasing: Rinse with deionized water and drain the water...

Embodiment 2

[0093] Example 2 Preparation of the material for promoting digestive tract mucosa repair of the present invention

[0094] 1. The preparation of the material for promoting digestive tract mucosa repair of the present invention

[0095] 1. Preparation of SIS

[0096] The SIS of the present invention can be purchased as a commercial product, or can be prepared according to the following method.

[0097] (1) Cleaning and finishing: take the fresh pig small intestine half an hour after slaughter, wash away the contents of the small intestine with water, turn over the small intestine, add salt and rub it, rinse it repeatedly with water for 3 times, cut open the small intestine with a scalpel, and then cut it into 15 cm long of the intestinal segment.

[0098] (2) Isolate the SIS: scrape off the muscular layer and serosa layer with a tongue depressor, and store in normal saline at 4°C overnight.

[0099] (3) Degreasing: Rinse with deionized water and drain the water with gauze. ...

Embodiment 3

[0109] Example 3 The preparation of the material for promoting the repair of digestive tract mucosa of the present invention

[0110] 1. The preparation of the material for promoting digestive tract mucosa repair of the present invention

[0111] 1. Preparation of SIS

[0112] The SIS of the present invention can be purchased as a commercial product, or can be prepared according to the following method.

[0113] (1) Cleaning and finishing: take the fresh pig small intestine half an hour after slaughter, wash away the contents of the small intestine with water, turn over the small intestine, add salt and rub it, rinse it repeatedly with water for 3 times, cut open the small intestine with a scalpel, and then cut it into 15 cm long of the intestinal segment.

[0114] (2) Isolate the SIS: scrape off the muscular layer and serosa layer with a tongue depressor, and store in normal saline at 4°C overnight.

[0115] (3) Degreasing: Rinse with deionized water and drain the water wi...

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PUM

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Abstract

The invention discloses a digestive tract mucous membrane promotion material. The digestive tract mucous membrane promotion material is prepared by crosslinking genipin and small intestinal submucosa, and the crosslinking index of the small intestinal submucosa crosslinked by genipin is 30-100%. The invention also discloses a preparation method and a use of the digestive tract mucous membrane restoration promotion material. The digestive tract mucous membrane restoration promotion material has the advantages of good acid and pepsin degradation resistance, low hemolytic property, no cytotoxicity and excellent mechanical properties.

Description

technical field [0001] The invention relates to a repair material, in particular to a repair material for digestive tract mucosa. Background technique [0002] Peptic ulcers mainly refer to chronic ulcers that occur in the stomach and duodenum, and can also occur in the lower segment of the esophagus, around the gastrojejunostomy, and in MECKEL’s diverticulum containing ectopic gastric mucosa. The formation of these ulcers is related to Gastric acid is related to the digestion of pepsin, so it is called peptic ulcer. Peptic ulcer is one of the common clinical diseases of the digestive system. In recent years, with the acceleration of the pace of life, changes in diet structure and irregular eating time, the incidence rate has gradually increased. The occurrence of peptic ulcer is related to many factors. The common clinical causes include hypersecretion of gastric acid, bile reflux, HP (Helicobacter pylori) infection, and decreased gastric mucosal defense ability. The cour...

Claims

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Application Information

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IPC IPC(8): A61L31/16A61L31/00
Inventor 解慧琪王旻龚梅
Owner TOPREGMED BEIJING MEDICAL TECH CO LTD
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