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Calcium borate silicate biological material, preparation method and application of calcium borate silicate biological material

A biomaterial, calcium borosilicate technology, used in dental preparations, pharmaceutical formulations, dental prostheses, etc.

Active Publication Date: 2014-09-24
青岛蓝皓生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] So far, there are literature [G. Giuli, L. Bindi, and P. Bonazzi, Rietveld refinement of okayamalite, Ca 2 SiB 2 o 7 : Structural evidence for the B / Si ordered distribution, American Mineralogist, 2000, 85(10): 1512-1515] reported Ca 2 SiB 2 o 7 structure, while the pure phase calcium borosilicate Ca 2 SiB 2 o 7 material has not been reported as a biomaterial

Method used

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  • Calcium borate silicate biological material, preparation method and application of calcium borate silicate biological material

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Experimental program
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Effect test

Embodiment 1

[0052] Preparation of Ca 2 SiB 2 o 7

[0053] (1) According to the chemical formula Ca 2 SiB 2 o 7 , respectively weighed calcium carbonate CaCO 3 : 4.04 g, silica SiO 2 : 1.21 g, boric acid H 3 BO 3 : 2.61 grams, after grinding and mixing in an agate mortar, select the air atmosphere for the first calcination, the temperature is 350 ° C, the calcination time is 2 hours, then cool to room temperature, take out the sample; the raw material calcined for the first time is fully Mix and grind evenly, then calcinate again in the air atmosphere, the temperature is 550 ° C, the calcining time is 10 hours, then cool to room temperature, take out the sample; finally it is fully ground again and calcined in the air in the muffle furnace, the calcining temperature is 950 ℃, the calcination time is 3 hours, that is, Ca 2 SiB 2 o 7 Powder.

[0054] (2) will get Ca 2 SiB 2 o 7 The powder was soaked in simulated body fluid (SBF) for 1 day and 7 days for mineralization, and th...

Embodiment 2

[0061] Preparation of Ca 2 SiB 2 o 7

[0062] (1) According to the chemical formula Ca 2 SiB 2 o 7, weigh calcium nitrate Ca(NO 3 ) 2 4H 2 O: 9.45 g, boric acid H 3 BO 3 : 2.47 grams, respectively dissolved with an appropriate amount of nitric acid, mixed to obtain A solution; weigh tetraethyl orthosilicate Si (OC 2 h 5 ) 4 : 4.17 grams, add absolute ethanol and deionized water, mix and stir to obtain B solution; mix A and B solutions, adjust PH=2 with nitric acid, continue to stir, then age and dry to obtain the precursor; After grinding and mixing uniformly in the agate mortar, choose the air atmosphere for the first calcination, the temperature is 350 ° C, the calcination time is 5 hours, then cool to room temperature, and take out the sample; the raw materials for the first calcination are fully mixed and ground again, and the Calcined again in the air atmosphere, the temperature is 450 ℃, the calcination time is 15 hours, then cooled to room temperature, and ...

Embodiment 3

[0067] Preparation of Ca 2 SiB 2 o 7

[0068] (1) According to the chemical formula Ca 2 SiB 2 o 7 , respectively weigh calcium oxide CaO: 4.49 grams, silicate H 2 SiO 3 : 3.12 g, boron trioxide B 2 o 3 : 2.78 grams, after grinding and mixing in an agate mortar, select the air atmosphere for the first calcination, the temperature is 400 ° C, the calcination time is 14 hours, then cool to room temperature, take out the sample; the raw material for the first calcination is fully Mix and grind evenly, then calcinate again in the air atmosphere, the temperature is 600°C, the calcining time is 6 hours, then cool to room temperature, and take out the sample.

[0069] (2) Grind the calcium borosilicate powder, then weigh 2 grams of the powder, and dry press it at 8 MPa to make a ceramic green body with a diameter of 20 mm and a thickness of 2 mm; put the calcium borosilicate ceramic green body at 950 Calcined at ℃ for 3 hours to prepare calcium borosilicate ceramic discs. ...

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Abstract

The invention discloses a calcium borate silicate biological material, a preparation method and application of the calcium borate silicate biological material. Pure-phase calcium borate silicate Ca2SiB2O7 powder is synthesized through a solid-phase synthesis method or a sol-gel method or a coprecipitation method, and the calcium borate silicate powder also can be pressed and formed so that calcium borate silicate ceramic blocks can be acquired. After the prepared calcium borate silicate material is placed in simulated body fluid (SBF) for soaking and mineralization, a bone-like apatite layer is deposited on the surface of the material, and the thickness of hydroxyapatite obtained after mineralization is increased along with soaking time. The prepared calcium borate silicate biological material has good biological performance, is suitable for being used as a material for bone tissue repair and filling and dentistry repair, and is a new biological and medical material.

Description

technical field [0001] The present invention relates to a kind of calcium borosilicate biological material, preparation method and application, particularly relate to a kind of chemical formula is Ca 2 SiB 2 o 7 A calcium borosilicate biological material belongs to the field of biological materials. Background technique [0002] Natural bone is a complex biocomposite material with a precise hierarchical structure. It is constructed by organic and inorganic components. The organic component is mainly Type I collagen, which endows bone tissue with elasticity and toughness. The composition is mainly composed of calcium phosphate (Calcium phosphate), especially biological apatite (Biological apatite), which endows bone tissue with sufficient rigidity and strength. An ideal bone tissue engineering scaffold material should have a three-dimensional multi-level network structure. For an ideal bone tissue "repair" or "replacement" strategy, the material composition of the implant ...

Claims

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Application Information

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IPC IPC(8): C04B35/01C04B35/622C04B35/624A61L27/02A61K6/027
Inventor 黄彦林祁淑云
Owner 青岛蓝皓生物技术有限公司
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