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Method for implanting functional biological coating on surface of implant

A bio-coating, implant technology, applied in surface reaction electrolytic coating, coating, prosthesis and other directions, can solve the problems of long time consumption, complicated operation, unsatisfactory slow release effect, etc., and achieve rapid process and cheap raw materials. , the effect of facilitating large-scale promotion and use

Active Publication Date: 2014-09-03
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More importantly, the traditional siRNA loading method has disadvantages such as complicated operation, long time-consuming, and unsatisfactory slow-release effect, so it is necessary to develop a more ideal loading method

Method used

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  • Method for implanting functional biological coating on surface of implant
  • Method for implanting functional biological coating on surface of implant
  • Method for implanting functional biological coating on surface of implant

Examples

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Embodiment 1

[0034] Embodiment 1: Applied to bone implant materials

[0035] The siRNA in this example is: siRNA against Ckip-1 designed and synthesized by Shanghai Gemma Co., Ltd. according to the needs of osteogenesis, named siCkip-1. refer to figure 1 As shown, the method steps are as follows:

[0036] (1) Select pure titanium material provided by Northwest Institute of Nonferrous Metals to process bone implants;

[0037] (2) After the surface is polished, use acetone, absolute ethanol and deionized water to ultrasonically clean for 30 minutes, and dry it for use;

[0038] (3) prepare anodic oxidation electrolyte: deionized water is solvent, HF wt0.5% (mass percentage);

[0039] (4) Preparation of titanium dioxide nanotubes by anodic oxidation method: the titanium implant is used as the anode, and the platinum sheet or graphite is used as the cathode, which is put into the electrolyte prepared in the previous step. 1 hour, the distance between the two stages is 5mm, and the reaction...

Embodiment 2

[0052] Embodiment 2: Applied to cardiovascular stent

[0053] The siRNA used in this example is: according to the need for promoting the function of endothelial cells, Shanghai Gemma Company designed and synthesized siRNA against sFlt-1, named siFlt-1.

[0054] (1) Select pure titanium materials provided by Northwest Institute of Nonferrous Metals to process into cardiovascular stents;

[0055] (2) After the surface is polished, use acetone, absolute ethanol and deionized water to ultrasonically clean for 30 minutes, and dry it for use;

[0056] (3) prepare anodic oxidation electrolyte: deionized water is solvent, HF wt0.5% (mass percentage);

[0057] (4) Preparation of titanium dioxide nanotubes by anodic oxidation method: titanium vascular stent is used as anode, platinum sheet or graphite is used as cathode, and put into the electrolyte prepared in the previous step. The specific anodic oxidation parameters are: DC voltage 5-20V, power-on time For 0.5 hours, the two-stage...

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Abstract

The invention relates to a method for implanting a functional biological coating on the surface of an implant. The method is characterized in that a functional biological coating is implanted on surface of the implant in an electrolytic deposition manner, the implant is a dental implant, a bone implant or a cardiovascular stent, and the functional biological coating is a siRAN coating, a miRNA coating or a DNA coating. The method has the advantages that chitosan and a functional biological material are jointly deposited on the surface of a titanium dioxide nanotube array on the basis that chitosan has a characteristic of cathodic electrodeposition and has a transfer effect on the functional biological material, and as the pH value of chitosan changes after electrodeposition, the dissolution rate of the chitosan slows down, and the controlled-release characteristic of the functional biological material can be realized to a certain degree.

Description

technical field [0001] The invention first forms a titanium dioxide nanotube array on the surface of a titanium implant, and then constructs an siRNA biological coating on the surface of the nanotube, which belongs to the technical field of planting materials; relates to the construction of an siRNA slow-release coating, and belongs to the research on the application of RNAi technology on the surface of materials field. Background technique [0002] Titanium implants are currently widely used in clinical practice, mainly in dental implants, bone implant materials, cardiovascular stents and other fields, with excellent biological activity and irreplaceability. With the increase of the world's aging population, tooth loss and cardiovascular diseases are becoming more and more prominent, and the number of applications of titanium implants is also increasing day by day. [0003] In the application of titanium implants, the biological activity of the implant surface is a crucial...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C25D9/02C25D11/26A61L27/54A61L27/30A61L31/16A61L31/08A61L27/06A61L31/02
Inventor 张玉梅宋文张力
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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