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Method for making simvastatin drug-containing hydroxyapatite coating on surface of pure titanium

A technology of hydroxyapatite and simvastatin, which is applied in coating, medical science, electrolytic inorganic material coating, etc., can solve the problems of planting failure and achieve the effects of low cost, promotion of proliferation and differentiation, and high biocompatibility

Inactive Publication Date: 2014-08-06
THE STOMATOLOGIAL HOSPITAL OF ZHEJIANG UNIV SCHOOL OF MEDICINE
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Problems solved by technology

At present, the surface of implants widely used in clinical practice generally adopts SLA technology, that is, the surface is roughened by sand blasting and acid etching, and its clinical application effect is better, but for patients with poor local bone conditions, there are still implant failures

Method used

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Embodiment Construction

[0010] After polishing, sandblasting and acid etching the surface of the pure titanium implant, the electrochemical deposition station is used to deposit simvastatin-containing hydroxyapatite coating on the implant surface with relatively simple instruments and relatively cheap materials. layer. In view of the limitations of other surface treatment methods for adding drugs, the present invention chooses the electrochemical deposition method to establish a relatively simple drug deposition platform.

[0011] The present invention is characterized in that the pure titanium implant is treated by sandblasting and acid etching, and the hydroxyapatite coating containing simvastatin is prepared on the surface of the implant by electrochemical method, so as to find a low-cost and high-efficiency easy-to- The preparation method of the finished drug-containing coating.

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Abstract

The invention discloses a method for depositing a simvastatin drug-containing hydroxyapatite coating on the surface of pure titanium by utilizing an electrochemical deposition process. The method comprises the following steps: polishing the surface of a pure titanium implant, sand-blasting, acid-etching, and depositing by utilizing an electrochemical deposition station, a simple apparatus and cheap materials to make the simvastatin drug-containing hydroxyapatite coating on the surface of the implant. The method has the advantages of simple preparation process, simple apparatus, low making cost, high making efficiency and the like, and the obtained coating has good biocompatibility and osteogenic cell proliferation differentiation promotion ability. A platform for making the drug-containing coating on the surface of pure titanium is established.

Description

technical field [0001] The invention relates to a method for preparing a drug-containing hydroxyapatite coating on the surface of pure titanium. In particular, it relates to a method for depositing a hydroxyapatite coating containing simvastatin on the surface of pure titanium by using an electrochemical deposition method. Background technique [0002] With the continuous improvement of implant technology, more and more patients with missing teeth choose implant restoration treatment. However, long-term tooth loss or some systemic diseases, such as osteoporosis, may lead to insufficient bone mass or changes in bone quality in the implant area, thereby affecting the success rate and long-term stability of the implant. Many studies have confirmed that the surface morphology and chemical composition of implants play an important role in the osseointegration of implants. Simvastatin is a fat-soluble statin that induces BMP-2 mRNA expression and stimulates bone formation. Hydr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/54C25D9/04
Inventor 杨国利石珏赵士芳何福明
Owner THE STOMATOLOGIAL HOSPITAL OF ZHEJIANG UNIV SCHOOL OF MEDICINE
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