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Laetiporus sulphureus extract and application thereof

A technology of extract and sulfur bacteria, applied in application, food science, drug combination, etc., to achieve stable quality, good safety, and reduce adverse reactions

Active Publication Date: 2014-08-06
神农架天润生物科技有限责任公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are few reports on the efficacy of sulfur bacteria, such as: application number: 99110871.X, name of invention: a sulfur bacteria preparation for regulating gastrointestinal function and its production method, the present invention relates to a sulfur bacteria preparation for regulating gastrointestinal function and its production method

Method used

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  • Laetiporus sulphureus extract and application thereof
  • Laetiporus sulphureus extract and application thereof
  • Laetiporus sulphureus extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation of embodiment 1 sulfur bacteria extract and trihydropinepinic acid B

[0029] 1. Experimental materials

[0030] 1.1. Experimental bacteria

[0031] Sulfur bacteria (Laetiporus sulfureus (Fr.) Muttill) was identified by Prof. Wang Shaobo of Three Gorges Tourism Vocational and Technical College and provided fruiting bodies and strains.

[0032] 1.2. Experimental reagents

[0033] 95% medical alcohol, double distilled water, chromatographic grade acetonitrile, petroleum ether, acetone, etc.

[0034] 1.3. Experimental Instruments

[0035] KQ-500DB Ultrasonic Cleaner, Airon Rotary Evaporator (Germany), ME215S 1 / 100,000 Electronic Balance (Germany Sartorios Company), Ultraviolet Spectrophotometer (UV-2201, Japan Shimadzu Company), High Performance Liquid Phase Chromatograph (DIONEX Ultimate3000, Diane Liquid Chromatography Co., Ltd., USA), NMR (UltrashiedTM400MHZ Plus, bruker Bruker), freeze dryer (FREEZONE PLUS6, LABCONCO).

[0036] 2. Experimental meth...

Embodiment 2

[0053] The preparation of embodiment 2 pharmaceutical tablet of the present invention

[0054]Take the alcohol extract of sulfur bacteria or trihydropine acid B, add starch and 1% magnesium stearate, press into tablets, so that each tablet contains 0.1-1.0 g of alcohol extract of sulfur bacteria, or 10-100 mg of dental acid. (Adjuvant used can be commonly used in tablets such as microcrystalline cellulose, modified starch, ethyl cellulose, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose, etc. one or several of the excipients).

Embodiment 3

[0055] The preparation of embodiment 3 pharmaceutical capsules of the present invention

[0056] Take the alcohol extract of sulfur bacteria or trihydropine acid B, add starch, granulate, granulate, pack into capsules, each capsule contains 0.1-0.5g of alcohol extract of sulfur bacteria, or 10-100mg of trihydropine acid B . (Adjuvant used can be microcrystalline cellulose, modified starch, ethyl cellulose, methyl cellulose, hydroxyethyl cellulose, hydroxypropyl methyl cellulose, sodium carboxymethyl cellulose and other capsules commonly used one or several of the excipients).

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Abstract

The invention provides a laetiporus sulphureus extract. The weight percentage of trametenloic acid B in the extract is 1-12 percent. The invention also provides application of the extract and the compound trametenloic acid B therein. The laetiporus sulphureus is a common edible fungus, has good safety, and can be prepared by large-scale fermentation; the prepared laetiporus sulphureus extract is stable in quality and strong in controllability; the laetiporus sulphureus extract and the traametenloic acid B obtained by separation have remarkable anti-inflammatory activity, can be used for treating acute and chronic rheumatic arthritis and rheumatoid arthritis, acute and chronic hepatitis, mastitis and other inflammatory diseases, can inhibit COX2 and reduce release of PGE2 (prostaglandin E2) and other inflammatory mediums, and provides a novel administration choice for clinical application.

Description

technical field [0001] The invention relates to a sulfur bacteria extract. Background technique [0002] Sulfur bacteria (Laetiporus sulphureus (Bull.) Murrill), also known as sulfur-colored cheese bacteria and sulfur polypores, belong to Basidiomycetes, Polyporaceae, Polyporaceae, and Polypores. It is a large fungus that is used both as medicine and food. Regular consumption can improve health. Its fruiting body contains enruicoic acid, which can synthesize steroid drug adrenal cortex hormone, and is an important drug for preventing and treating various diseases. [0003] At present, there are few reports on the efficacy of sulfur bacteria, such as: application number: 99110871.X, name of invention: a sulfur bacteria preparation for regulating gastrointestinal function and its production method, the present invention relates to a sulfur bacteria preparation for regulating gastrointestinal function and its production method. Sulfur bacteria preparations include: Sulfur ba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/07A61K31/575A61P29/00A23L1/30
Inventor 汪鋆植孙文军杨进武玲罗华军程凡贺海波李伟
Owner 神农架天润生物科技有限责任公司
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