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Gold nanorod chirality structure construction method and detection method of copper ions

A technology of gold nanorods and chiral structure, which is applied in measuring devices, material analysis through optical means, instruments, etc., can solve the problems caused by Alzheimer's disease, Parkinson's disease, etc., and achieve low-cost, non-toxic, Simple steps and high reproducibility

Active Publication Date: 2014-07-23
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Copper ion is an essential transition metal ion in animals and plants, but excessive copper ions can lead to many serious consequences, such as Alzheimer's disease, Parkinson's disease, etc. (Liu, X.; Zhang, N.; Bing, T.; Shangguan, D., Carbon Dots Based Dual-Emission Silica Nanoparticles as a Ratiometric Nanosensor for Cu. Anal Chem 2014, 86, 2289-2296. Zhang, J.; Zhang, L.; Wei, Y.; Ma , J.; Shuang, S.; Cai, Z.; Dong, C., A selectively fluorescein-based colorimetric probe for detecting copper (II) ion. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy2013, 122, 731-736.)

Method used

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  • Gold nanorod chirality structure construction method and detection method of copper ions
  • Gold nanorod chirality structure construction method and detection method of copper ions
  • Gold nanorod chirality structure construction method and detection method of copper ions

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Experimental program
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Effect test

Embodiment 1

[0063] Select the gold nanorod solution synthesized by the commonly used seed method, add hexadecyltrimethylammonium bromide concentration after purification, respectively 0.3, 0.5, 0.8, 1mM, take 1.0mL respectively, add 7.5μL 20mM sodium citrate to it , mixed evenly; put into a 27°C constant temperature water bath; measure the extinction spectrum of the above mixed solution over time with an ultraviolet-visible absorption spectrophotometer, and the measurement temperature is 27°C.

[0064] The results of the extinction spectrum changing with time are as follows figure 2 Shown, it shows the influence of surfactant hexadecyltrimethylammonium bromide concentration on gold nanorod side-by-side assembly in the method of the present invention, when surfactant concentration is lower, assemble too fast, can cause chaos to assemble ; When the surfactant concentration is high, the reaction is too slow to realize the side-by-side assembly of gold nanorods in a short time. Based on thi...

Embodiment 2

[0066] Select the gold nanorod solution synthesized by the commonly used seed method, add hexadecyltrimethylammonium bromide concentration after purification to 0.5mM, take 1.0mL, add 0.1, 0.15, 0.3, 0.5, 1mM sodium citrate , mixed evenly; put into a 27°C constant temperature water bath; measure the extinction spectrum of the above mixed solution over time with an ultraviolet-visible absorption spectrophotometer, and the measurement temperature is 27°C.

[0067] The results of the extinction spectrum changing with time are as follows image 3 Shown, it shows the impact of sodium citrate concentration on the side-by-side assembly of gold nanorods in the method of the present invention, when the sodium citrate concentration was low, the assembly speed was slow; when the sodium citrate concentration was high, the reaction was too fast, Easy to form chaotic assembly of gold nanorods in a short time. Based on this, the present invention can adjust the side-by-side assembly speed o...

Embodiment 3

[0069] Select the gold nanorod solution synthesized by the commonly used seed method, take 1.0mL of gold nanorods with concentrations of 0.025, 0.05, 0.1, and 0.15nM, and add hexadecyltrimethylammonium bromide at a concentration of 0.5mM after purification. Add 0.15mM sodium citrate thereto, mix well; put into 27°C constant temperature water bath; measure the extinction spectrum of the above mixed solution over time with an ultraviolet-visible absorption spectrophotometer, and the measurement temperature is 27°C.

[0070] The results of the extinction spectrum changing with time are as follows Figure 4 As shown, it shows the influence of the concentration of gold nanorods in the side-by-side assembly in the method of the present invention, when the concentration of gold nanorods is lower, the assembly speed is faster, and a chaotic assembly of gold nanorods is formed in a short period of time; When the nanorod concentration is high, the reaction rate is moderate, and it is ea...

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Abstract

The invention relates to a chirality assembling structure construction method formed by a gold nanorod side-by-side assembly and sulfydryl-containing chiral molecule and a method for detecting copper ions with high sensitivity by using Plasmon circular dichroism signal. After adding the sulfydryl-containing chiral molecule in the nanorod side-by-side assembly, the chiral molecule is adsorbed on the gold nanorod rod surface by forming gold-sulphur bond to twist the gold nanorod rod and form PCD signals. Copper ions can catalyze and dissolve oxygen and oxidize the sulfydryl-containing chiral molecule to form disulphide; as the latter is weak in adsorption on the gold nanorod rod, the chiral assembly PCD signals are changed. By utilizing the principle, the pmol-magnitude copper ions are measured by establishing the relationship between the copper ions to be tested and the chiral assembly structure PCD signals.

Description

technical field [0001] The invention relates to a method for constructing a chiral structure of gold nanorods and a method for detecting copper ions, in particular to an ultrasensitive detection method for copper ions based on the surface plasmon circular dichroism signal of gold nanorods assembled side by side. Background technique [0002] In 2009, Kotov et al. (Chen, W.; Bian, A.; Agarwal, A.; Liu, L.; Shen, H.; Wang, L.; Xu, C.; Kotov, N.A., Nanoparticle superstructures made by polymerase chain reaction: collective interactions of nanoparticles and a new principle for chiral materials. Nano letters 2009, 9, 2153-2159.) Tetrahedral assembly of spherical gold nanoparticles was obtained by using polymerase chain reaction (Polymerase Chain Reaction, PCR) body, and discovered the plasmonic circle dichroism (Plasmonic Circle Dichroism, PCD) phenomenon of the assembly. Following the pioneering work of Kotov et al., the phenomenon of PCD of complexes and assemblies of noble met...

Claims

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Application Information

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IPC IPC(8): G01N21/19
CPCG01N21/19G01N21/554
Inventor 温涛侯帅张会颜娇吴晓春
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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