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Traditional Chinese medicine compound preparation for reducing postoperative recurrence and metastasis of colorectal cancer and preparation method of traditional Chinese medicine compound preparation

A technology for recurrence and metastasis, colorectal cancer, applied in the direction of medical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as toxicity and side effects, and achieve the effects of simple preparation, wide drug sources, and easy material acquisition

Inactive Publication Date: 2014-07-09
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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Problems solved by technology

Due to the severe toxic and side effects of chemotherapy, the limited use of targeted drug therapy due to costs and other factors has seriously affected the improvement of patient survival and brought a huge economic burden to the society and the people. the bottleneck

Method used

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  • Traditional Chinese medicine compound preparation for reducing postoperative recurrence and metastasis of colorectal cancer and preparation method of traditional Chinese medicine compound preparation
  • Traditional Chinese medicine compound preparation for reducing postoperative recurrence and metastasis of colorectal cancer and preparation method of traditional Chinese medicine compound preparation
  • Traditional Chinese medicine compound preparation for reducing postoperative recurrence and metastasis of colorectal cancer and preparation method of traditional Chinese medicine compound preparation

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Embodiment Construction

[0023] The beneficial effect of the medicine of the present invention will be further illustrated by the following test examples, which include animal pharmacodynamic experiments and clinical curative effect observation tests of the traditional Chinese medicine compound preparation for reducing postoperative recurrence and metastasis of colorectal cancer of the present invention.

[0024] Animal experiment

[0025] 1. Animals: 60 BALB / c female nude mice aged 4-5 weeks, weighing 20-24 g (Shanghai Experimental Animal Center), were raised in a specific pathogen-free (SPF) environment.

[0026] 2. Method:

[0027] After the skin of each nude mouse was disinfected, 0.2ml of LOVO cell suspension was subcutaneously injected on the back of the neck with a 1ml syringe, and 2×10 cells were inoculated. 6 / mouse, a total of 60 mice, after the average diameter of the transplanted tumor was about 5mm (the 16th day after cell planting), the nude mice were randomly divided into a blank cont...

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Abstract

The invention relates to a traditional Chinese medicine compound preparation for reducing postoperative recurrence and metastasis of colorectal cancer and a preparation method of the traditional Chinese medicine compound preparation. The traditional Chinese medicine compound preparation is prepared from the following traditional Chinese medicine raw material medicines in parts by weight: 10-30 parts of codonopsis pilosula, 10-15 parts of poria cocos, 10-15 parts of rhizoma atractylodis macrocephalae, 10-15 parts of rhizoma smilacis glabrae, 10-30 parts of chinaroot greenbriers, 10-15 parts of fiveleaf akebia fruits, 5-15 parts of endothelium corneum gigeriae galli and 3-10 parts of pericarpium citri reticulatae. The traditional Chinese medicine compound preparation provided by the invention has the functions of invigorating spleen and supplementing qi and strengthening the body resistance and detoxifying, and comprehensively treats postoperative colorectal cancer, and reduces recurrence and metastasis of colorectal cancer, so that the preparation is low in cost, safe and effective and free from toxic and side effects, can reduce expression of serum VEGF (Vascular Endothelial Growth Factor), P53, COX-2 and survivin, and remarkably reduces metastasis of postoperative colorectal cancer and improves the living quality of the patient.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a compound traditional Chinese medicine preparation for reducing postoperative recurrence and metastasis of colorectal cancer and a preparation method thereof. Background technique [0002] Since the beginning of the 21st century, with the improvement of people's living standards, the incidence of colorectal cancer has been greatly increased. According to statistics, the incidence of colorectal cancer in my country has a tendency to double compared with the 1960s and 1970s, accounting for the fourth place among all malignant tumors. In recent years, with the research on the molecular level of colorectal cancer etiology and the development of molecular biology, more and more scholars believe that colorectal cancer is caused by both the external environment (exogenous carcinogens / pre-carcinogens) and the internal environment ( Genetic susceptibility) is the result of jo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61P35/04A61P35/00A61K35/37A61K35/57
Inventor 钟薏窦丽萍王燕莹吴婷婷李园金燕顾怡中张静钱呈秋罗春蕾
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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