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Method for detecting No and/or propofol in expiratory gas

A technology of exhaled breath and propofol, applied in the direction of measuring devices, material analysis by electromagnetic means, instruments, etc., can solve problems such as accidents, lack of understanding or timely diagnosis, etc., achieve less consumables, convenient continuous monitoring, and reduce The effect of the influence of the background

Inactive Publication Date: 2014-06-18
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Asthma is a difficult problem for epidemiologists because its triggers are ubiquitous and inescapable
Many asthma patients or potential asthma patients do not understand or diagnose the complication in time and take corresponding treatment measures, which leads to accidents during the operation

Method used

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  • Method for detecting No and/or propofol in expiratory gas
  • Method for detecting No and/or propofol in expiratory gas
  • Method for detecting No and/or propofol in expiratory gas

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Separately measure NO and propofol standard gases according to the above-mentioned embodiment. image 3 -5 are the ion mobility spectra of reagent ion peak (RIP), NO and different injection amounts of propofol in negative ion mode, respectively. The migration time of the RIP peak in the negative ion mode is 9.28ms, the migration time of the NO ion peak is 8.30ms, and propofol only has an ion peak at 15.33ms at a lower concentration, and when the concentration increases, the migration time There is also an ion peak at 20.40ms, which has been confirmed to be the ion peak of propofol dimer.

Embodiment 2

[0038] NO and propofol standard gas mixtures were measured according to the above-mentioned embodiment.

[0039] Image 6 Simultaneous measurement of ion mobility spectra of NO and propofol in a clean air atmosphere after drying the system. It can be seen from the figure that when the two are measured at the same time, the two will undergo a complex reaction to form a new complex, and its ion migration time is 15.82ms, and the ion of the propofol monomer at 15.33ms behind the peak. It shows that the two can be measured at the same time, and the complexes of the two can also confirm the existence of each other.

Embodiment 3

[0041] The NO and propofol gas in the exhaled breath were separately measured according to the above-mentioned embodiment.

[0042] Figure 7 -8 are the ion mobility spectra of the background of exhaled breath, NO and propofol in the simulated exhaled breath, respectively. It can be seen from the figure that there are more unknown substances in the background of exhaled breath, and more peaks appear near the RIP peak, but relatively fewer peaks appear at longer migration times. When NO is added into the exhaled air, it enters the transfer tube together with the exhaled air for measurement, and the ion peak of NO can be obtained at 8.34ms. Similarly, when propofol is added into the exhaled breath and enters the migration tube together for measurement, the peaks of propofol monomer and dimer will also appear at about 15.31ms and 20.38ms. This demonstrates that ion mobility spectrometry can measure both NO and propofol anesthetics in exhaled breath alone.

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Abstract

The present invention discloses a method for detecting NO and / or propofol in expiratory gas. According to the method, an ion mobility spectrometry technology is adopted as the basis, air is adopted as an air supply source of carrier gas and drift gas, and the NO content and the propofol content in expiratory gas can be simultaneously, sequentially or separately measured; and with application of the method to detect NO and / or propofol in expiratory gas, advantages of rapid detection, high sensitivity, direct measurement without pre-treatment, real-time online monitoring and the like are provided, wherein the detection limitations of the propofol and the NO respectively can achieve 0.5 ppb and 4 ppb.

Description

technical field [0001] The invention relates to a method for analyzing propofol and / or NO in exhaled air, in particular to a method for rapidly detecting NO and propofol in exhaled air. Background technique [0002] Nitric oxide (NO) is widely distributed in various tissues in living organisms, especially in nerve tissues. It is an extremely unstable biological free radical with small molecules and simple structure. It is a gas at room temperature. It is slightly soluble in water and has fat solubility. It can quickly diffuse through biological membranes. It has a very important biological function and has been widely valued by people. Nitric oxide (NO) in the respiratory tract is a small molecular substance produced by endothelial cells, epithelial cells, and inflammatory cells, and exists in the exhaled air of children with asthma. Therefore, the content of NO in exhaled breath can reflect the inflammation of human endothelial cells, epithelial cells and inflammatory cel...

Claims

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Application Information

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IPC IPC(8): G01N27/62G01N27/622
Inventor 李海洋彭丽英李京华王新渠团帅周庆华
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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