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Oral ibuprofen pellet xerogel and preparation method thereof

A micropellet gel and xerogel technology, which is applied in the direction of pharmaceutical formulations, medical preparations containing active ingredients, organic active ingredients, etc., to achieve excellent dispersion or disintegration speed, reduce vomiting side effects, and reduce the number of times of taking medicine.

Active Publication Date: 2014-05-14
黑龙江童医生儿童生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Combining the pellets and gel proposed by the present invention to make the technical problem of ibuprofen pellets oral xerogel composite dosage form has not been reported yet

Method used

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  • Oral ibuprofen pellet xerogel and preparation method thereof
  • Oral ibuprofen pellet xerogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Ibuprofen 100g Crystalline cellulose 40g Starch slurry 35g Acrylic resin 20g

[0061] Carrageenan 400g Potassium Chloride 20g Sucrose 2000g Strawberry Flavor 50g

[0062] Potassium sorbate 15g

[0063] Preparation method: uniformly mix ibuprofen with crystalline cellulose and starch slurry to make a soft material, then extrude and spheronize to make drug-containing pills, or make drug-containing pills in a fluidized bed; then pass the drug-containing pills through Fluidized bed coating is made into ibuprofen pellets; Carrageenan, potassium chloride, sucrose, strawberry essence, and potassium sorbate are sieved respectively (50 mesh) and mixed with ibuprofen pellets, fully stirred to make them Mix evenly; subpackage, that is.

Embodiment 2

[0065] Ibuprofen 90g Lactose 30g Starch slurry 30g Ethyl cellulose 15g

[0066] Konjac Gum 350g Calcium Chloride 30g Sucrose 2000g Orange Flavor 40g

[0067] Ethylparaben 5g

[0068] Preparation method: uniformly mix ibuprofen, lactose, and starch slurry to make a soft material, then extrude and spheronize to make drug-containing pills, or make drug-containing pills in a fluidized bed, and then fluidize the drug-containing pills Bed coating is made into ibuprofen pellets; Konjac gum, calcium chloride, sucrose, orange essence, and ethyl p-hydroxybenzoate are sieved (50 mesh) respectively and mixed with ibuprofen pellets, fully stirred, so that It is mixed evenly; subpackage, that is.

Embodiment 3

[0070] Ibuprofen 80g Starch 28g Starch slurry 50g Hydroxypropyl methylcellulose 12g

[0071] Carrageenan 120g Konjac Gum 180g Calcium Chloride 25g Xylitol 2000g

[0072] Lemon essence 45g sorbic acid 8g

[0073] Preparation method: uniformly mix ibuprofen with starch and starch slurry to make a soft material, then extrude and spheronize to make drug-containing pills, or make drug-containing pills in a fluidized bed, and then fluidize the drug-containing pills bed coating to make ibuprofen pellets; sieve carrageenan, konjac gum, calcium chloride, xylitol, lemon flavor, and sorbic acid respectively (50 mesh) and mix with ibuprofen pellets, stir well, Make it mix evenly; subpackage, that is.

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Abstract

The invention relates to oral ibuprofen pellet xerogel and a preparation method thereof. The oral ibuprofen pellet xerogel comprises ibuprofen pellets evenly distributed in a xerogel matrix, wherein the xerogel matrix contains a xerogel forming agent, a curing agent, a sweetening agent, an aromatic and a preservative. The oral ibuprofen pellet xerogel consists of, by weight, raw materials including ibuprofen 20-100 parts, filler 10-100 parts, binding agent 5-60 parts, pellet coating material 2-20 parts, xerogel forming agent 100-400 parts, cutting agent 5-30 parts, sweetening agent 10-2000 parts, aromatic 10-50 parts and preservative 1-15 parts. The oral ibuprofen pellet xerogel has the advantage of being high in pharmaceutical stability, exquisite in appearance, good in taste, convenient to take, high in bioavailability, good in patient (especially children) medication compliance, accurate in dosage, simple in preparation process, convenient to carry and transport and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to ibuprofen oral micropellet xerogel and a preparation method thereof. Background technique [0002] Ibuprofen (IBUPROFEN) is an antipyretic and analgesic drug, white crystalline powder, insoluble in water, easily soluble in ethanol, chloroform, ether, acetone and other solvents; it has a peculiar smell and is tasteless. Soluble in sodium hydroxide or sodium carbonate test solution. [0003] Making ibuprofen and an appropriate amount of matrix into an oral dry gel preparation has advantages that other dosage forms cannot match. Such as Chinese patent CN1634011A discloses a kind of ibuprofen gel preparation and its preparation method, the purpose of this patent is to provide old people and children very willing to take, delicious and good new dosage form of therapeutic effect. However, ibuprofen is an aromatic organic acid and is insoluble in water. It is necessary to di...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K9/16A61K31/192A61P29/00
Inventor 刘晓磊姜波王娜闫婉露
Owner 黑龙江童医生儿童生物制药有限公司
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