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Preparation method for acyclovir emulsifiable paste

A technology of acyclovir cream and total amount, which is applied in the direction of ointment delivery, emulsion delivery, skin diseases, etc., to achieve good patient tolerance, convenient medication, and good quality stability

Active Publication Date: 2014-04-30
ZHENGZHOU HANDU PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral absorption of acyclovir is poor, and the bioavailability is only 20%. At present, this value decreases with the increase of the dose, and the concentration of ACV in the epidermis of in vitro topical administration is 48 times higher than that of oral administration.

Method used

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  • Preparation method for acyclovir emulsifiable paste
  • Preparation method for acyclovir emulsifiable paste
  • Preparation method for acyclovir emulsifiable paste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] A preparation method of acyclovir cream, comprising the steps of:

[0018] 1) Prepare a total of 100g of the following raw materials: 2g of acyclovir, 4g of cetostearyl alcohol, 2g of glyceryl monostearate, 4g of white petrolatum, 4g of glycerin, 0.5g of sodium lauryl sulfate, hydroxybenzene 0.2 g of ethyl ester, 0.5 g of dimethyl sulfoxide, 0.2 g of 5 wt % benzalkonium bromide solution, and the balance is purified water.

[0019] 2) Prepare the water phase: Put the water phase materials glycerin, sodium lauryl sulfate, ethylparaben, dimethyl sulfoxide, purified water, 5wt% benzalkonium bromide solution and acyclovir into the water phase in proportion In the tank, stir at 90°C for 20 minutes until uniform, then set aside;

[0020] 3) Prepare the oil phase: add cetostearyl alcohol, glyceryl monostearate and white petrolatum into the oil phase tank in proportion to the oil phase materials, stir at 82°C for 20 minutes until uniform, and set aside;

[0021] 4) Preparation...

Embodiment 2

[0023] A preparation method of acyclovir cream, comprising the steps of:

[0024] 1) Prepare a total of 100g of the following raw materials: 3g of acyclovir, 6g of cetostearyl alcohol, 5g of glyceryl monostearate, 6g of white petrolatum, 6g of glycerin, 1g of sodium lauryl sulfate, ethyl hydroxybenzoate 0.3 g of ester, 1 g of dimethyl sulfoxide, 0.5 g of 5 wt % benzalkonium bromide solution, and the balance is purified water.

[0025] 2) Prepare the water phase: Put the water phase materials glycerin, sodium lauryl sulfate, ethylparaben, dimethyl sulfoxide, purified water, 5wt% benzalkonium bromide solution and acyclovir into the water phase in proportion In the tank, stir at 95°C for 25 minutes until uniform, then set aside;

[0026] 3) Prepare the oil phase: add cetostearyl alcohol, glyceryl monostearate and white petrolatum into the oil phase tank in proportion to the oil phase materials, stir at 85°C for 25 minutes until uniform, and set aside;

[0027] 4) Preparation of...

Embodiment 3

[0029] A preparation method of acyclovir cream, comprising the steps of:

[0030] 1) Prepare a total of 100g of the following raw materials: 4g of acyclovir, 8g of cetostearyl alcohol, 8g of glyceryl monostearate, 8g of white petrolatum, 8g of glycerin, 1.5g of sodium lauryl sulfate, hydroxybenzene 0.4 g of ethyl ester, 1.5 g of dimethyl sulfoxide, 0.8 g of 5 wt % benzalkonium bromide solution, and the balance is purified water.

[0031] 2) Prepare the water phase: Put the water phase materials glycerin, sodium lauryl sulfate, ethylparaben, dimethyl sulfoxide, purified water, 5wt% benzalkonium bromide solution and acyclovir into the water phase in proportion In the tank, stir at 95°C for 20 minutes until uniform, then set aside;

[0032] 3) Prepare the oil phase: add cetostearyl alcohol, glyceryl monostearate and white petrolatum into the oil phase tank in proportion to the oil phase materials, stir at 87°C for 20 minutes until uniform, and set aside;

[0033] 4) Preparation...

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Abstract

The invention discloses a preparation method for an acyclovir emulsifiable paste, and belongs to the field of chemical medicinal preparations. The method comprises four steps of raw material preparation, water phase preparation, oil phase preparation and emulsifiable paste preparation. The acyclovir emulsifiable paste prepared by employing the preparation method is good in quality stability, is capable of rapidly permeating skin and being reserved for a relatively long time, is convenient to use and good in patient tolerance, causes no adverse reactions, and is worth for clinic popularization and application.

Description

technical field [0001] The invention belongs to the field of chemical drug preparations, and in particular relates to a preparation method of acyclovir cream. Background technique [0002] Herpes zoster is an acute skin disease caused by varicella-zoster virus, which is characterized by clusters of blisters distributed in bands along the peripheral nerves of the skin on one side of the body surface. Often accompanied by neuralgia and local lymph node swelling and pain, the course of the disease is about 2 to 3 weeks. [0003] Aciclovir (Aciclovir, ACV) is a nucleoside antiviral drug that selectively inhibits a variety of herpes viruses. In virus-infected host cells, ACV is infected by herpes simplex virus (HSV) or varicella zoster Thymidine kinase of virus (VZV) or cytomegalovirus (CMV) UL97 gene product is phosphorylated to acyclovir monophosphate (ACV-MP), which is phosphorylated by guanylate kinase to acyclovir diphosphate Virus (ACV-DP), finally, is converted by cellu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/522A61P31/22A61P17/00
Inventor 王娟李俊霞程永科白艳鹤
Owner ZHENGZHOU HANDU PHARMA GROUP
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