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Acyclovir cream

A technology of acyclovir cream and total amount, which is applied in the direction of ointment delivery, emulsion delivery, skin diseases, etc., can solve the problems of poor absorption, etc., and achieve good patient tolerance, no adverse reactions, and convenient medication Effect

Active Publication Date: 2015-09-16
ZHENGZHOU HANDU PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral absorption of acyclovir is poor, and the bioavailability is only 20%. At present, this value decreases with the increase of the dose, and the concentration of ACV in the epidermis of in vitro topical administration is 48 times higher than that of oral administration.

Method used

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  • Acyclovir cream
  • Acyclovir cream
  • Acyclovir cream

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A kind of acyclovir emulsifiable paste, be made up of each raw material that following total amount is 100g: acyclovir 2g, cetostearyl alcohol 4g, glyceryl monostearate 2g, white vaseline 4g, glycerin 4g, 0.5 g of sodium lauryl sulfate, 0.2 g of ethylparaben, 0.5 g of dimethyl sulfoxide, 0.2 g of 5 wt % benzalkonium bromide solution, and the balance is purified water.

[0017] Preparation:

[0018] 1) Prepare the water phase: Put the water phase materials glycerin, sodium lauryl sulfate, ethylparaben, dimethyl sulfoxide, purified water, 5wt% benzalkonium bromide solution and acyclovir into the water phase in proportion In the tank, stir at 90°C for 20 minutes until uniform, then set aside;

[0019] 2) Prepare the oil phase: add cetostearyl alcohol, glyceryl monostearate and white petrolatum into the oil phase tank in proportion to the oil phase materials, stir at 82°C for 20 minutes until uniform, and set aside;

[0020] 3) Preparation of cream: transfer the above-men...

Embodiment 2

[0022] A kind of acyclovir emulsifiable paste, be made up of each raw material that following total amount is 100g: acyclovir 3g, cetostearyl alcohol 6g, glyceryl monostearate 5g, white vaseline 6g, glycerin 6g, 1 g of sodium lauryl sulfate, 0.3 g of ethylparaben, 1 g of dimethyl sulfoxide, 0.5 g of 5 wt % benzalkonium bromide solution, and the balance is purified water.

[0023] Preparation:

[0024] 1) Prepare the water phase: Put the water phase materials glycerin, sodium lauryl sulfate, ethylparaben, dimethyl sulfoxide, purified water, 5wt% benzalkonium bromide solution and acyclovir into the water phase in proportion In the tank, stir at 95°C for 25 minutes until uniform, then set aside;

[0025] 2) Prepare the oil phase: add cetostearyl alcohol, glycerol monostearate and white petrolatum into the oil phase tank in proportion to the oil phase materials, stir at 85°C for 25 minutes until uniform, and set aside;

[0026] 3) Preparation of cream: transfer the above-mention...

Embodiment 3

[0028] A kind of acyclovir emulsifiable paste, be made up of each raw material that following total amount is 100g: acyclovir 4g, cetostearyl alcohol 8g, glyceryl monostearate 8g, white vaseline 8g, glycerin 8g, 1.5 g of sodium lauryl sulfate, 0.4 g of ethylparaben, 1.5 g of dimethyl sulfoxide, 0.8 g of 5 wt % benzalkonium bromide solution, and the balance is purified water.

[0029] Preparation:

[0030] 1) Prepare the water phase: Put the water phase materials glycerin, sodium lauryl sulfate, ethylparaben, dimethyl sulfoxide, purified water, 5wt% benzalkonium bromide solution and acyclovir into the water phase in proportion In the tank, stir at 95°C for 20 minutes until uniform, then set aside;

[0031] 2) Prepare the oil phase: add cetostearyl alcohol, glyceryl monostearate and white petrolatum into the oil phase tank in proportion to the oil phase materials, stir at 87°C for 20 minutes until uniform, and set aside;

[0032] 3) Preparation of cream: transfer the above-men...

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Abstract

The invention relates to an acyclovir emulsifiable paste, and belongs to the field of chemical medicinal preparations. The emulsifiable paste is prepared from the following raw materials with the total amount of 100 parts by weight: 2-5 parts of acyclovir, 4-10 parts of cetostearyl alcohol, 2-10 parts of monoglyceride stearate, 4-10 parts of white vaseline, 4-10 parts of glycerin, 0.5-2 parts of sodium dodecyl sulfate, 0.2-0.5 part of ethylparaben, 0.5-2 parts of dimethyl sulfoxide, 0.2-1.0 part of benzalkonium bromide solution with a concentration of 5 wt%, and the balance purified water. The acyclovir emulsifiable paste provided by the invention is good in quality stability, is capable of rapidly permeating skin and being reserved for a relatively long time, is convenient to use and good in patient tolerance, causes no adverse reactions, and is worth for clinic popularization and application.

Description

technical field [0001] The invention belongs to the field of chemical pharmaceutical preparations, and in particular relates to an external medicine for treating herpes simplex or herpes zoster infection - acyclovir cream. Background technique [0002] Herpes zoster is an acute skin disease caused by varicella-zoster virus, which is characterized by clusters of blisters distributed in bands along the peripheral nerves of the skin on one side of the body surface. Often accompanied by neuralgia and local lymph node swelling and pain, the course of the disease is about 2 to 3 weeks. [0003] Aciclovir (Aciclovir, ACV) is a nucleoside antiviral drug that selectively inhibits a variety of herpes viruses. In virus-infected host cells, ACV is infected by herpes simplex virus (HSV) or varicella zoster Thymidine kinase of virus (VZV) or cytomegalovirus (CMV) UL97 gene product is phosphorylated to acyclovir monophosphate (ACV-MP), which is phosphorylated by guanylate kinase to acycl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/522A61P31/22A61P17/00
Inventor 王娟李俊霞程永科白艳鹤
Owner ZHENGZHOU HANDU PHARMA GROUP
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