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Squalene and beta-carotene composition polycystic lipidosome preparation method and application thereof for decreasing free radical and reducing harm

A multivesicular liposome and carotene technology, applied in the field of chemistry, can solve problems such as no report, no multivesicular liposome preparation technology and application report, etc., and achieves strong air permeability, large surface area, and increased stability. Effect

Inactive Publication Date: 2014-04-30
GUANGDONG BRANCH OF CHINA TOBACCO GENERAL +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The study of processing these free radical scavengers into multivesicular liposomes and putting them into cigarette filters to scavenge gas-phase free radicals (reduced radicals) has not been reported, let alone a synergistic composition based on squalene and β-carotene Preparation technology and application report of multivesicular liposome

Method used

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  • Squalene and beta-carotene composition polycystic lipidosome preparation method and application thereof for decreasing free radical and reducing harm
  • Squalene and beta-carotene composition polycystic lipidosome preparation method and application thereof for decreasing free radical and reducing harm
  • Squalene and beta-carotene composition polycystic lipidosome preparation method and application thereof for decreasing free radical and reducing harm

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Experimental program
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Effect test

Embodiment 1

[0049] Prepare each component according to the following parts by mass: 15 grams (g) of lecithin; Those skilled in the art can use other sources of squalene) 5 grams (g); Those skilled in the art can use other sources of β-carotene) 45 grams (g); cetyl alcohol 15 grams (g); low molecular weight hydroxyethyl starch 20 grams (g).

[0050] The preparation steps are:

[0051] S1. Dissolving phospholipids, squalene and β-carotene in 100mL propylene glycol to obtain a mixed system;

[0052] S2. Transfer the mixed system obtained in S1 into 50 mL of water containing 15 g of cetyl alcohol, homogenize at a high speed to make it fully mixed, and obtain a homogenized mixed system;

[0053] S3. Add low molecular weight hydroxyethyl starch to the homogenized mixing system obtained in S2 and stir evenly to form a stable particle suspension;

[0054] S4. Freeze-drying the microparticle suspension obtained in S3 to obtain multivesicular liposomes containing squalene and β-carotene.

Embodiment 2

[0056] Each component was prepared according to the following parts by mass: 15 grams of soybean lecithin; 10 grams of squalene; 40 grams of β-carotene; 15 grams of stearyl alcohol; 20 grams of low molecular weight hydroxyethyl starch.

[0057] The preparation steps are:

[0058] S1. Dissolve soybean lecithin, squalene and β-carotene in 100 milliliters (mL) of propylene glycol to obtain a mixed system;

[0059] S2. Transfer the mixed system obtained in S1 into 50 mL of water containing 15 g of stearyl alcohol, homogenize at a high speed to make it fully mixed, and obtain a homogenized mixed system;

[0060] S3. Add low molecular weight hydroxyethyl starch to the homogenized mixing system obtained in S2 and stir evenly to form a stable particle suspension;

[0061] S4. Freeze-drying the microparticle suspension obtained in S3 to obtain multivesicular liposomes containing squalene and β-carotene.

[0062] Water and propylene glycol are used in the preparation process of the mu...

Embodiment 3

[0064] Each component was prepared according to the following parts by mass: 15 grams of hydrogenated soybean lecithin; 15 grams of squalene; 35 grams of β-carotene; 15 grams of glycerin;

[0065] The preparation steps are:

[0066] S1. Dissolve hydrogenated soybean lecithin, squalene and β-carotene in 100 milliliters (mL) of propylene glycol to obtain a mixed system;

[0067] S2. Transfer the mixed system obtained in S1 into 50 mL of water containing 15 g of glycerin, homogenize at a high speed to make it fully mixed, and obtain a homogenized mixed system;

[0068] S3. Add medium molecular weight hydroxyethyl starch to the homogenized mixing system obtained in S2 and stir evenly to form a stable particle suspension;

[0069] S4. Freeze-drying the microparticle suspension obtained in S3 to obtain multivesicular liposomes containing squalene and β-carotene.

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Abstract

The invention discloses a squalene and beta-carotene composition polycystic lipidosome preparation method and an application thereof for decreasing free radical and reducing harm. The polycystic lipidsome is prepared by materials including 10-15 parts of phospholipid, 10-20 parts of stabilizers, 8-15 parts of surfactants and the balance of squalene and beta-carotene composition. The polycystic lipidsome is applied to cigarettes, and functions of decreasing the free radical and reducing the harm can be achieved. Since especially the polycystic lipidsome is placed into cigarette filters made of cellulose acetate fibers during forming of cigarette filter rods, when consumers smoke and tobacco smoke passes through the polycystic lipidosome of the built-in filters, the antioxidants are in full contact with the mainstream tobacco smoke due to large surface area of the polycystic lipidosome, the smoke-phase free radical in the mainstream tobacco smoke can be effectively eliminated, and powerful technical support is provided for solving the problems about smoking and health.

Description

technical field [0001] The invention relates to the technical field of chemistry, and more specifically relates to a multivesicular liposome containing squalene and β-carotene composition, a preparation method thereof and an application in cigarette base reduction and harm reduction. Background technique [0002] Thousands of compounds produced by smoking and the harm caused by high concentration of free radicals to the human body have attracted widespread attention. Free radicals have the strongest effect on the body and are the most harmful. They can cause lung disease, heart disease and cancer. These free radicals can cause serious damage to smokers. Smoking produces high concentrations of free radicals, including relatively long-lived solid-phase free radicals, quinones and semiquinones, polycyclic aromatic hydrocarbons free radicals, and reactive oxygen free radicals produced by their reactions with oxygen such as superoxide anion (O 2 - ), hydrogen peroxide (H 2 o ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A24D3/14
Inventor 陈泽鹏韦建玉江定心郑荣豪王晓宾贺广生郭俊杰
Owner GUANGDONG BRANCH OF CHINA TOBACCO GENERAL
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