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Sea cucumber intestine extract composite soft capsules and preparation method thereof

A technology for compounding soft capsules and American ginseng extracts, which is applied in the directions of capsule delivery, drug combination, pharmaceutical formulation, etc., can solve the problems of low efficiency, incomplete removal, and single ingredients of sea cucumber intestines artificially removing sand and mud, and achieves easy digestion and absorption. , The preparation method is reasonable and the composition is scientific.

Active Publication Date: 2014-04-23
SHANDONG HOMEY AQUATIC DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to overcome the shortcomings of single ingredients, low efficacy, low efficiency and incomplete removal of sea cucumber sausage artificially in sea cucumber sausage products given in the prior art, the present invention provides a sea cucumber sausage extract compound soft capsule and its preparation The method, the preparation method has reasonable technology, scientific ingredients, simple operation, strong operability, and is easy to realize industrial production; the compound soft capsule of sea cucumber sausage extract prepared by this method has anti-fatigue, anti-aging, hypolipidemic, anti-tumor, and beneficial effects. Skin beauty, enhance immunity and other effects

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0032] A preparation method of sea cucumber intestinal extract compound soft capsule, through the following process steps:

[0033] a, preparation of sea cucumber rice rolls

[0034] a1. Pretreatment of sea cucumber sausages: select fresh sea cucumber sausages as raw materials, place them in a colloid mill, add water 8 times the weight of sea cucumber sausages, and grind to obtain sea cucumber sausage pulp;

[0035] a2. Enzymolysis Put the obtained sea cucumber intestine pulp into an enzymolysis container, heat it to 95°C and keep it for 25 minutes to denature the protein; then cool it to 55°C, adjust the pH value to 7, add neutral protease and flavor enzyme double enzyme , enzymatic hydrolysis for 4 hours; wherein, the enzyme activity ratio of neutral protease and flavor enzyme is 1:1.5, and the total enzyme dosage of neutral protease and flavor enzyme is 2000u / g sea cucumber sausage; after enzymolysis is completed, heat to 95°C to inactivate 25min, to obtain sea cucumber in...

Embodiment 2

[0052] A preparation method of sea cucumber intestinal extract compound soft capsule, through the following process steps:

[0053] a, preparation of sea cucumber rice rolls

[0054] a1. Pretreatment of sea cucumber sausages: select fresh sea cucumber sausages as raw materials, place them in a colloid mill, add water 10 times the weight of sea cucumber sausages, and perform grinding treatment to obtain sea cucumber sausage pulp;

[0055] a2. Enzymolysis Put the obtained sea cucumber intestine pulp into an enzymolysis container, heat to 100°C and keep for 20 minutes to denature the protein; then cool to 60°C, adjust the pH value to 8, add neutral protease and flavor enzyme double enzyme , enzymatic hydrolysis for 3 hours; wherein, the enzyme activity ratio of neutral protease and flavor enzyme is 1:2, and the total enzyme dosage of neutral protease and flavor enzyme is 1500u / g sea cucumber sausage; after enzymolysis is completed, heat to 100°C to inactivate the enzyme 20min to...

Embodiment 3

[0072] A preparation method of sea cucumber intestinal extract compound soft capsule, through the following process steps:

[0073] a, preparation of sea cucumber rice rolls

[0074] a1. Pretreatment of sea cucumber sausages: select fresh sea cucumber sausages as raw materials, place them in a colloid mill, add water 5 times the weight of sea cucumber sausages, and grind to obtain sea cucumber sausage slurry;

[0075] a2. Enzymolysis Put the obtained sea cucumber intestine pulp into an enzymolysis container, heat to 90°C, keep for 30 minutes to denature the protein; then cool to 50°C, adjust the pH value to 6, add neutral protease and flavor enzyme double enzyme , enzymatic hydrolysis for 5 hours; wherein, the enzyme activity ratio of neutral protease and flavor enzyme is 1:1, and the total enzyme dosage of neutral protease and flavor enzyme is 1500u / g sea cucumber sausage; after enzymolysis is completed, heat to 90°C to inactivate the enzyme 30min, to obtain sea cucumber int...

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Abstract

The present invention relates to sea cucumber intestine extract composite soft capsules and a preparation method thereof. The preparation method comprises: adopting sea cucumber intestine produced through fresh sea cucumber processing as a raw material, carrying out slurry grinding, carrying out a heating treatment, cooling, adding two enzymes such as neutral protease and flavor enzyme, and controlling the enzymes to carry out enzymolysis; carrying out centrifugation twice on the enzymolysis solution, adopting a nano-filtration separation technology to carry out a desalting treatment on the collected supernatant, and drying the obtained sea cucumber intestine solution to obtain the sea cucumber intestine powder; and compounding the sea cucumber intestine powder, traditional Chinese medicine extracts such as a medlar extract, a milkvetch root extract, an American ginseng extract, a siraitia grosvenorii extract, a rhodiola rosea extract and a common yam rhizome extract, and auxiliary materials such as soybean oil and beeswax to obtain the sea cucumber intestine extract composite soft capsules. According to the present invention, the preparation method has characteristics of reasonable process and strong operability; and the prepared sea cucumber intestine extract composite soft capsules have characteristics of scientific component and reasonable matching, and further have effects of fatigue resistance, aging resistance, blood fat lowering, anti-tumor, skin benefiting, beautifying, and immunity improving.

Description

technical field [0001] The invention relates to a pharmaceutical preparation characterized by capsule preparations, in particular to a compound soft capsule of sea cucumber sausage extract and a preparation method thereof. Background technique [0002] Sea cucumber is one of the precious seafood. It contains more than 50 kinds of nutrients that are beneficial to human physiological activities. Among them, the protein content is high, and the trace elements are rich in types. It also has the functions of anticoagulation, antitumor, antibacterial, antiviral and improving immunity. In recent years, there have been more and more enterprises processing sea cucumbers. The leftovers in the processing of sea cucumbers—the sea cucumber intestines contain nutrients that are no less than those in the body wall. The vanadium content of its dry sausage is 12 parts per million, about 3 times higher than that of its body. It has the effect of warming the middle, tonifying deficiency and ...

Claims

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Application Information

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IPC IPC(8): A61K36/8945A61K9/48A61P39/00A61P39/06A61P3/06A61P35/00A61P37/04A61K35/56A61K35/616
Inventor 袁文鹏刘昌衡孙永军史亚萍齐君乔若瑾黄婕胡炜贾爱荣刘新夏雪奎鞠文明唐晓波毕春雨
Owner SHANDONG HOMEY AQUATIC DEV
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