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Nine chrysanthemum a and its composition and its application in pharmacy and food

A technology of nonapyramide and composition, which is applied in the directions of drug combination, medical preparations containing active ingredients, food science, etc., and can solve the problems such as the activity that has no prospect for the treatment of diabetic nephropathy or chronic nephropathy.

Inactive Publication Date: 2016-05-11
KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there are no related reports on the compound of the present invention and its activity with promising therapeutic prospects for diabetic nephropathy or chronic kidney disease

Method used

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  • Nine chrysanthemum a and its composition and its application in pharmacy and food
  • Nine chrysanthemum a and its composition and its application in pharmacy and food
  • Nine chrysanthemum a and its composition and its application in pharmacy and food

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Separation and purification of compound 1 nonapongamide A[(±)-AspongamideA]:

[0024] Take Aspongopus chinensis Dallas, crush it, and extract it with petroleum ether (60-90°C) (3×80L), acetone (3×80L) and 50% methanol (3×80L) at room temperature, stirring continuously. The 50% methanol extraction fractions were combined, the solvent was recovered under reduced pressure to obtain an extract (1 kg), which was suspended with an appropriate amount of water, and then extracted three times with an equal volume of n-butanol, and the solvent was recovered under reduced pressure to obtain an n-butanol extract (100 g). The n-butanol extract was subjected to MCIgel CHP20P column chromatography, gradient methanol water elution (10%-100%), ferric chloride-potassium ferricyanide (1:1) reagent color tracking, positive spots were merged, and LC- MS tracking molecular weight is in the component of 450-600 Dalton interval, obtains component Fr.3 (10.5g), and it is through SephadexLH-20 f...

Embodiment 2

[0033] The compound Aspongamide A[(±)-AspongamideA] obtained in Example 1 can be made into an injection after adding water for injection according to the conventional method, finely filtering, potting and sterilizing.

Embodiment 3

[0035] The compound Aspongamide A[(±)-AspongamideA] obtained in Example 1 was dissolved in sterile water for injection, filtered with a sterile funnel, subpackaged, freeze-dried at low temperature, and aseptically melt-sealed to obtain a powder injection.

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PUM

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Abstract

Provides a dopamine trimer with a novel structure, that is, a dopamine trimer extracted from Jiuxiangworm, an insect traditional Chinese medicine that can warm the middle and help yang, and a pharmaceutical composition containing it, as well as its preparation for treating diabetic nephropathy or chronic kidney disease. application in medicine or health food. The clinical application of the theory of worm dredging collaterals shows that collaterals are related to microvascular lesions. Ninecyclopamide A can significantly inhibit high glucose-induced mesangial cell secretion of extracellular matrix and inflammatory factors, and is an inhibitor of Smad3 phosphorylation, which can significantly inhibit TGF-β1-induced Smad3 phosphorylation and Smad3 expression, in view of TGF-β / Smads signaling pathway is the main pathology mediating organ fibrosis, suggesting the application value of this compound in chronic kidney disease including diabetic nephropathy and renal fibrosis.

Description

Technical field: [0001] The present invention belongs to the technical field of medicines, and in particular, relates to nonapearamide A, a pharmaceutical composition containing it and its application in preparing medicine or health food for treating diabetic nephropathy or chronic kidney disease. Background technique: [0002] The hazards, pathological mechanisms, and methods and principles of drug research of diabetic nephropathy or chronic kidney disease are clearly described by the applicant in the published patent application (Chinese patent publication number: CN102153630A). In short, chronic kidney disease presents a high incidence and refractory situation in the world. [0003] Modern studies have shown that the TGF-β / Smads signaling pathway is the main pathological mechanism mediating chronic kidney disease, including diabetic nephropathy and renal fibrosis. Smad3 hyperphosphorylation has adverse effects on the kidney, so its effective prevention will be beneficial...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D319/24A61K31/357A61P3/10A61P13/12A23L33/10
CPCC07D319/14
Inventor 程永现晏永明吕青
Owner KUNMING INST OF BOTANY - CHINESE ACAD OF SCI
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