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Injectable hollow hydroxyapatite microsphere/chitosan composite drug carrier material and preparation method thereof

A technology of hollow hydroxyapatite and empty hydroxyapatite, which is applied in the field of biomedical materials, can solve the problems of short release period and drug burst release, achieve good mechanical properties and improve the effect of sustained release performance

Inactive Publication Date: 2014-04-02
TONGJI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have also shown that compounding drugs with chitosan-based materials alone has the defects of drug burst release and short release period at the initial stage of treatment.

Method used

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  • Injectable hollow hydroxyapatite microsphere/chitosan composite drug carrier material and preparation method thereof
  • Injectable hollow hydroxyapatite microsphere/chitosan composite drug carrier material and preparation method thereof
  • Injectable hollow hydroxyapatite microsphere/chitosan composite drug carrier material and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0028] In a hollow hydroxyapatite microsphere / chitosan composite drug carrier material: the dispersed phase is the hollow hydroxyapatite microsphere, and the continuous phase is the hydrogel prepared by chitosan and beta-glycerophosphate sodium. The preparation process of the composite drug carrier is as follows:

[0029] (1) Preparation of hollow hydroxyapatite microspheres: weigh 7.4g Li 2 CO 3 , 10gCaCO 3 and 97.6 g H 3 BO 3 Powder, mix thoroughly in a mortar. The mixed powder was placed in a platinum crucible, and heated and melted for 30 minutes in a silicon carbide rod high-temperature furnace at 1100°C. Quenching and quenching the molten glass liquid to produce borate glass, in which Li 2 O, CaO, B 2 o 3 The molar ratios are 10%, 10% and 80%, respectively. After breaking the glass block, glass particles with an average particle size of 2-5 μm are obtained. The sieved glass particles were sprayed into a tube furnace at 700°C to make spherical borate glass micro...

Embodiment 2

[0035] The preparation process of the composite drug carrier carrying lysozyme is as follows:

[0036] (1) Preparation of hollow hydroxyapatite microspheres: weigh 7.4g Li 2 CO 3 , 10gCaCO 3 and 97.6 g H 3 BO 3 Powder, mix thoroughly in a mortar. The mixed powder was placed in a platinum crucible, and heated and melted for 30 minutes in a silicon carbide rod high-temperature furnace at 1100°C. Quenching and quenching the molten glass liquid to produce borate glass, in which Li 2 O, CaO, B 2 o 3 The molar ratios are 10%, 10% and 80%, respectively. After breaking the glass block, glass particles with an average particle size of 2-5 μm are obtained. The sieved glass particles were sprayed into a tube furnace at 700°C to make spherical borate glass microspheres. Weigh 1g of spheroidized glass microspheres and add to 100ml of K with a concentration of 0.25mol / L and a pH of 9.0 2 HPO 4 solution, put it in a constant temperature box at 25°C, and take it out after soaking ...

Embodiment 3

[0041] The preparation process of the composite drug carrier carrying vancomycin is as follows:

[0042] (1) Preparation of hollow hydroxyapatite microspheres: weigh 7.4g Li 2 CO 3 , 10gCaCO 3 and 97.6 g H 3 BO 3 Powder, mix thoroughly in a mortar. The mixed powder was placed in a platinum crucible, and heated and melted for 30 minutes in a silicon carbide rod high-temperature furnace at 1100°C. Quenching and quenching the molten glass liquid to produce borate glass, in which Li 2 O, CaO, B 2 o 3 The molar ratios are 10%, 10% and 80%, respectively. After breaking the glass block, glass particles with an average particle size of 2-5 μm are obtained. The sieved glass particles were sprayed into a tube furnace at 700°C to make spherical borate glass microspheres. Weigh 1g of spheroidized glass microspheres and add to 100ml of K with a concentration of 0.25mol / L and a pH of 9.0 2 HPO 4 solution, put it in a constant temperature box at 25°C, and take it out after soakin...

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Abstract

The invention discloses an injectable hollow hydroxyapatite microsphere / chitosan composite drug carrier material. The material comprises the following components in percentage by weight: 0.5-2wt% of hollow hydroxyapatite, 2wt% of chitosan, 5.6wt% of beta-sodium glycerophosphate and 90.4-91.9 wt% of water. The preparation method comprises the following steps: first, loading drug in the hollow sodium hydroxyapatite microsphere; then, preparing chitosan thermo-sensitive hydrogel; finally, mixing the drug-loaded hollow hydroxyapatite microsphere and the chitosan thermo-sensitive hydrogel in a solid-liquid ratio of (0.05-0.2)g / 10ml, and stirring to obtain the injectable hollow hydroxyapatite microsphere / chitosan composite drug carrier material. The material can realize slow and controlled release of drug, gives the material injectable molding property, and realizse minimally invasive therapy to bone defect or fracture.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an injectable hollow hydroxyapatite microsphere / chitosan composite drug carrier material and a preparation method thereof. Background technique [0002] Injectable hydrogel refers to a flowing liquid before injection, which can be injected subcutaneously into the body by injection, and can be gelled in situ to form a scaffold with a three-dimensional porous structure and play the role of bone conduction. Chitosan (CS for short) is the only alkaline polysaccharide that exists in large quantities in nature. It can be hydrolyzed by enzymolysis in the body. The product is non-toxic to the human body and has good tissue compatibility, biodegradability and viscosity. Adhesive, and widely sourced, cheap, easy to mass production. In addition, chitosan also has biological activities such as antithrombosis, promoting wound healing and reconstruction of soft and ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/10A61K47/04A61P19/08
Inventor 姚爱华李旭东王德平叶松
Owner TONGJI UNIV
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