Magnetic nano drug carrier and application thereof

A magnetic nanometer and drug technology, used in drug combinations, antineoplastic drugs, pharmaceutical formulations, etc., can solve the problems of difficult stable existence, inability to local sustained release, low magnetic permeability, etc. Toxic and side effects, enhancing the effect of chemotherapy drugs

Inactive Publication Date: 2019-03-12
SUN YAT SEN UNIV CANCER CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the above-mentioned magnetic drug carriers all have certain effective effects, they all have some obvious deficiencies: Magnetic albumin microspheres: large particle size, insufficient magnetic induction intensity, poor accumulation in tumor foci, and can cause Vascular embolism, gradually eliminated or improved; magnetic fluid: due to no package, strong reactivity, difficult to exist stably in blood; magnetic liposome: magnetic depends on Fe 3 o 4 produced, while Fe 3 o 4 Easy to generate impurities through chemical synthesis, easy to absorb other impurity ions, low magnetic permeability, chemically unstable in blood, easy to lose magnetism
In addition, for liver cancer, the magnetic field outside the body is far away from the lesion, which significantly affects the magnetic targeting efficiency. The nano-drug slow-release carrier administered through the hepatic artery is easily washed away by the blood flow, and cannot really play a local slow-release effect.
Therefore, similar studies are mostly limited to superficial tumors, and the efficacy in liver cancer is limited.
In addition, the existing magnetic drug carrier system is less involved in the research of thermotherapy effect

Method used

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  • Magnetic nano drug carrier and application thereof
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  • Magnetic nano drug carrier and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0032] The preparation method of the above-mentioned magnetic nano drug carrier is as follows: mixing the iron powder, hard magnetic material and carbon-coated iron. According to needs, pharmaceutically acceptable auxiliary solvents can also be further added to make a suspension for use.

[0033] The present invention also provides the application of the magnetic nanometer drug carrier in the preparation of drugs for treating tumors. Specifically, the tumor is a liver tumor.

[0034] In the above application, the magnetic nano-medicine carrier is placed in a medium-high frequency alternating magnetic field to cause a heating effect. The in vitro targeted heating effect of the above-mentioned magnetic nano drug carrier was detected, and the heating could be adjusted from room temperature to 60°C.

Embodiment 1

[0036] The present embodiment is a kind of magnetic nano medicine carrier, and the raw material that it adopts and preparation method are as follows:

[0037] Weigh 1g of Fe powder, 1g of BaFe 12 o 19 Mix with 0.3125g Fe@C (Fe@C adsorbs epirubicin at 160ug / mg, the amount of epirubicin generally required for tumor treatment is 50mg, and Fe@C is determined to be 0.3125g) to obtain magnetic nano drug carrier .

[0038] Put the obtained magnetic nano drug carrier into 10mL of base liquid (iodolized oil), stir it with a high-shear emulsifier for 5 minutes, then disperse it by ultrasonic waves with a power of 2000W and a frequency of 20KHz for 10 minutes, then cool for 5 minutes, continue ultrasonic dispersion for 10 minutes, repeat After 3 operations, test samples were obtained for testing:

[0039] Put the test sample in the induction coil of a 15kw high-frequency wave electric induction heating machine (purchased from Dongguan Hongfu Electromechanical Equipment Co., Ltd.), the...

Embodiment 2

[0041] The present embodiment is a kind of magnetic nano medicine carrier, and the raw material that it adopts and preparation method are as follows:

[0042] Weigh 1.5g Fe powder, 1g BaFe 12 o 19 Mix with 0.3125g Fe@C to obtain magnetic nano drug carrier.

[0043] Put the obtained magnetic nano drug carrier into 10mL of base liquid (iodolized oil), stir it with a high-shear emulsifier for 5 minutes, then disperse it by ultrasonic waves with a power of 2000W and a frequency of 20KHz for 10 minutes, then cool for 5 minutes, continue ultrasonic dispersion for 10 minutes, repeat After 3 operations, test samples were obtained for testing:

[0044] Put the test sample in the induction coil of a 15kw high-frequency wave electric induction heating machine. The heating time of the electromagnetic inductor is 500A, the oscillation frequency is 1.20KHz, and the heating time is 3 seconds, and the holding time is 3 seconds. The time taken for heating from room temperature (33.6° C.) to...

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Abstract

The invention relates to a magnetic nano drug carrier and application thereof. The magnetic nano drug carrier is prepared from components in parts by weight: 0.1-10 parts of iron powder, 0.1-10 partsof carbon-coated iron and 0.1-10 parts of hard magnetic material. The magnetic nano drug carrier can be warmed rapidly, has the large calorific powder, can be retained in the target area stably and for a long time to achieve the good drug slow releasing effect, and has the large drug carrying capacity, and low toxic and side effects.

Description

technical field [0001] The invention relates to the technical field of drug carriers, in particular to magnetic nanometer drug carriers and applications thereof. Background technique [0002] Since the development of the magnetic carrier system in the late 1970s, there have been many kinds: magnetic albumin microspheres, ferrofluids, magnetic liposomes, etc. The magnetic carrier used in animal experiments in the early stage is mainly magnetic albumin microspheres, which have high drug carrying rate, simple synthesis and convenient storage. Germany uses ferrofluid (particle size 100nm) as the carrier of epirubicin, which is injected into the body through intravenous injection, and a constant magnetic field is provided outside the skin of the tumor site to position the ferrofluid at the target site. First of all, by giving different concentrations of ferrofluid, observing a series of biochemical indicators, it is confirmed that the tolerance is very good. Subsequent injectio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/02A61K31/704A61P35/00
CPCA61K9/143A61K31/704A61P35/00
Inventor 郑云曾国勋张海燕邓云飞
Owner SUN YAT SEN UNIV CANCER CENT
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