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Cortex moutan microcapsule for treating allergic dermatitis, and preparation method and application thereof

A technology of allergic dermatitis and microcapsules, which is applied in the application field of fabrics, can solve the problems of short drug effect time, etc., and achieve the effect of simple preparation process, mild preparation conditions, and enhanced therapeutic effect

Active Publication Date: 2014-04-09
THE HONG KONG POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The second is that although the wet wrap therapy is effective, it only lasts for a few hours each time.

Method used

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  • Cortex moutan microcapsule for treating allergic dermatitis, and preparation method and application thereof
  • Cortex moutan microcapsule for treating allergic dermatitis, and preparation method and application thereof
  • Cortex moutan microcapsule for treating allergic dermatitis, and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 0.5 g of chitosan was dissolved in 25 ml of 2% acetic acid solution and stirred until completely dissolved to obtain chitosan acetic acid solution. 1.0g paeonol powder was uniformly dispersed in 25ml deionized water by ultrasonic dispersion, then 0.5g sodium alginate was added to it, and stirred at a high speed at 1000rpm until the sodium alginate was completely swollen. Then, the prepared chitosan acetic acid solution was added therein, and stirred at a high speed at 1000 rpm until the system was uniformly dispersed to obtain a ready-to-use mixture. At the same time, add 300ml of liquid paraffin in the three-necked flask, and add surfactant Span 80 to make its content reach 2%. Heat the mixture of liquid paraffin and Span 80 in a water bath at 100°C. When the temperature rises to 55°C, add the dispersed mixture. Stir at a high speed of 1000 rpm for 20 minutes, then stop heating and cool down with an ice bath. When the temperature drops below 10°C, use 5% NaOH solutio...

Embodiment 2

[0032] 1.25g of chitosan was dissolved in 50ml of 2% acetic acid solution, stirred until completely dissolved to obtain chitosan acetic acid solution. 0.5g of paeonol powder was uniformly dispersed in 25ml of deionized water by ultrasonic dispersion, then 1.0g of sodium alginate was added to it, and stirred at a high speed at 1000rpm until the sodium alginate was completely swollen. Then, the prepared chitosan acetic acid solution was added therein, and stirred at a high speed at 1000 rpm until the system was uniformly dispersed to obtain a ready-to-use mixture. At the same time, 450ml of liquid paraffin was added in a three-necked flask, and a mixture of Span 80 and Tween 80 in a ratio of 1:1 was added to make its content reach 2%. Heat the mixture of liquid paraffin, Span 80 and Tween 80 in a water bath at 100°C, and add the dispersed mixture when the temperature rises to 60°C. Stir at a high speed of 800 rpm for 25 minutes, then stop heating and cool down with an ice bath....

Embodiment 3

[0034] 0.2 g of chitosan was dissolved in 12 ml of 2% acetic acid solution and stirred until completely dissolved to obtain chitosan acetic acid solution. 1.0g paeonol powder was uniformly dispersed in 24ml deionized water by ultrasonic dispersion, then 1.0g sodium alginate was added thereto, and stirred at a high speed at 1200rpm until the sodium alginate was completely swollen. Then, the prepared chitosan acetic acid solution was added therein, and stirred at a high speed at 800 rpm until the system was evenly dispersed to obtain a ready-to-use mixture. Meanwhile, add 252ml liquid paraffin in the there-necked flask, and add surfactant Span 80, make its content reach 2%. Heat the mixture of liquid paraffin and Span 80 in a water bath at 100°C. When the temperature rises to 65°C, add the dispersed mixture. Stir at a high speed of 1000 rpm for 30 minutes, then stop heating and cool down with an ice bath. When the temperature dropped below 10°C, use 5% NaOH solution to adjust ...

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Abstract

The invention discloses a cortex moutan microcapsule for treating allergic dermatitis, and a preparation method thereof. The cortex moutan microcapsule comprises a cover layer formed by chitosan / sodium alginate, and cortex moutan powder disposed in the cover layer. The cirtex moutan microcapsule is prepared by an emulsion polymerization method. Meanwhile, the invention also discloses an application of the above cortex moutan microcapsule in manufacturing fabric for treating the allergic dermatitis. The cortex moutan microcapsule is fixed to the surface of the fabric. The cortex moutan microcapsule disclosed by the invention has not only significant functions for treating the allergic dermatitis but also good drug sustained release effect, so that the cortex moutan microcapsule can act on a patient for a long time. At the same time, since the cortex moutan microcapsule does not contain water, discomfort of skin cold caused by a wet wrapped therapy can be overcome when the cortex moutan microcapsule is applied in the fabric for treating the patient. The preparation method disclosed by the invention is simple in process and mild in conditions, thereby facilitating operation and control. The cortex moutan microcapsule can be adhered to the fabric through processes such as spraying, so that an application process can be implemented easily.

Description

technical field [0001] The invention belongs to the technical field of microcapsules, and relates to a paeonol microcapsule for treating atopic dermatitis and a preparation method thereof, and also relates to the application of the paeonol microcapsule in fabrics with the function of treating atopic dermatitis . Background technique [0002] Atopic dermatitis is a chronic skin inflammation whose incidence has increased over the past few decades. Because atopic dermatitis is prone to repeated attacks, it brings great inconvenience to the lives of patients and their families. Over the past two decades, wet wraps have been advocated as a relatively safe and effective treatment for patients with severe atopic dermatitis. However, this therapy still has many problems to be improved. One of them is that the wet wraps used during the treatment often make the patient uncomfortable and the skin is cold. The second is that although the wet wrap therapy is effective, the effect tim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K9/50A61K9/70A61K47/36A61M37/00A61P17/00A61P37/08
Inventor 许赐亮吴秀芬简志伟王文义周嫦娥
Owner THE HONG KONG POLYTECHNIC UNIV
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