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Bionic dental adhesive composition and preparation method thereof

A technology of adhesives and bionic teeth, which is applied in the field of dental restoration materials and its preparation, can solve the problems of falling off, insufficient cohesive force and failure of dental adhesives, and achieve good bonding effect, simple preparation process, The effect of broad research and application prospects

Inactive Publication Date: 2014-03-05
广州市易轩生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to simulate the structure of mussel protein and prepare a biomimetic dental adhesive composition by means of visible light polymerization, so as to solve the problem that the dental adhesive in the prior art has insufficient cohesive force and sometimes fails to cause shedding. question

Method used

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  • Bionic dental adhesive composition and preparation method thereof
  • Bionic dental adhesive composition and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The composition consists of 47% of dopamine derivatives, 45% of ethylene glycol dimethacrylate, 7% of 4-oxyethyl trimellitic anhydride, 0.5% of camphorquinone and 0.5% of N,N-di Composed of methylaminoethyl methacrylate.

[0019] The preparation steps of composition are as follows:

[0020] (1) Preparation of dopamine derivatives: first react salicylic acid and acrylic acid in a ratio of 1:1.2, the reaction conditions are concentrated sulfuric acid, and the temperature is 80-90°C to obtain salicylic acid ester; then the prepared Dissolve salicylate acrylate in an ethanol solution, inject nitrogen gas, then pour dopamine hydrochloride into the above solution, continue to stir for 3 hours while maintaining nitrogen gas at room temperature, and then perform purification to obtain dopamine derivatives;

[0021] (2) 4.7g dopamine derivatives are mixed with 4.5g ethylene glycol dimethacrylate and 0.7g 4-oxyethyl trimellitic anhydride methacrylate, and stirred evenly;

[002...

Embodiment 2

[0026] The composition consists of 35% of dopamine derivatives, 62% of ethylene glycol dimethacrylate, 1.5% of 4-methacrylate oxyethyl trimellitic anhydride, 0.8% of camphorquinone and 0.7% of N,N-di Composed of methylaminoethyl methacrylate.

[0027] The preparation steps of composition are as follows:

[0028] (1) Preparation of dopamine derivatives: first react salicylic acid and acrylic acid in a ratio of 1:1.2, the reaction conditions are concentrated sulfuric acid, and the temperature is 80-90°C to obtain salicylic acid ester; then the prepared Dissolve salicylate acrylate in an ethanol solution, inject nitrogen gas, then pour dopamine hydrochloride into the above solution, and continue stirring for 3.5 hours while maintaining nitrogen gas at room temperature, and then perform purification to obtain dopamine derivatives;

[0029] (2) 3.5g of dopamine derivatives are mixed with 6.2g of ethylene glycol dimethacrylate and 0.15g of 4-oxyethyl trimellitic anhydride methacryl...

Embodiment 3

[0034] The composition consists of 75% of dopamine derivatives, 20% of ethylene glycol dimethacrylate, 3.8% of 4-oxyethyl trimellitic anhydride, 0.6% of camphorquinone and 0.6% of N,N-di Composed of methylaminoethyl methacrylate.

[0035] The preparation steps of composition are as follows:

[0036] (1) Preparation of dopamine derivatives: first react salicylic acid and acrylic acid in a ratio of 1:1.2, the reaction conditions are concentrated sulfuric acid, and the temperature is 80-90°C to obtain salicylic acid ester; then the prepared Dissolve salicylate acrylate in an ethanol solution, inject nitrogen gas, then pour dopamine hydrochloride into the above solution, continue stirring for 2.5 hours at room temperature while maintaining nitrogen gas injection, and then perform purification to obtain dopamine derivatives;

[0037] (2) 7.5g dopamine derivative is mixed with 2g ethylene glycol dimethacrylate, 0.38g 4-oxyethyl trimellitic anhydride methacrylate, and stirred evenly...

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Abstract

The invention discloses a bionic dental adhesive composition and a preparation method thereof. The composition is composed of 20-75% of dopamine derivative, 20-70% of ethylene glycol dimethacrylate, 1.5-10% of 4-methacryloxyethyl trimellitic anhydride, 0.1-1% of camphorquinone and 0.1-1% of N,N-ethyl dimethylaminomethacrylate. The dental adhesive composition containing dopamine derivative is prepared by simulating the natural mussel protein structure; and the composition has the advantages of simple preparation technique and favorable bonding effect, and has wide application prospects.

Description

technical field [0001] The invention relates to a dental restoration material and a preparation method thereof, in particular to a bionic dental adhesive composition and a preparation method thereof. Background technique [0002] Marine mussels are aquatic organisms that stick themselves to reefs or the bottom of ships by secreting super strong mucus. Adheres securely to extremely difficult to adhere Teflon wheel surfaces. Studies have shown that the super mucus secreted by mussels is mussel adhesion protein, and the high content of dopamine (DOPA) in this protein is the main component of adhesion. The adhesive properties of mussel adhesive protein are almost universal, and it can be used as a biological adhesive, and is widely used in soft tissue bonding, artificial bone, broken bone bonding, oral restoration and ophthalmology. The method of direct extraction and genetic engineering from mussels has been able to obtain natural adhesive proteins; however, the extraction of...

Claims

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Application Information

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IPC IPC(8): A61K6/00C08F220/36C08F222/14C08F2/48
Inventor 高延敏王丹代仕梅
Owner 广州市易轩生物科技有限公司
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