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Process for extracting xanthophyll from Tagetes erecta

A technology of lutein and marigold, applied in the direction of organic chemistry, etc., can solve the problems of many operation steps, unfavorable industrial promotion and application, complicated operation, etc., and achieve the effect of simple process method, easy industrial production, and less usage

Inactive Publication Date: 2014-02-19
XIAN LVSEN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the prior art, the extraction method for lutein in marigolds is more complicated to operate, as the application number is 201110030487.4 patent "a method for extracting lutein from dried flowers of marigolds", which extracts leaves from marigolds. The method of flavin: crush the dried marigold flowers into 1.6-3.4mm, then add tetrahydrofuran to extract, then add alkaline alcohol solution for saponification, centrifuge after saponification, take the supernatant and add acid to adjust the pH value to 6.9-7.1, then concentrate and dry Get the lutein extract powder, then mix the extract powder with ether solvent, filter, and dry to get the crude lutein product, then mix the crude lutein product with distilled water, then centrifuge, and dissolve the precipitate with absolute ethanol Centrifuge again, and vacuum-dry the precipitate obtained by centrifugation to obtain lutein powder with a purity of more than 90%.
This method not only has many steps, but also needs to use tetrahydrofuran as a solvent, which is not conducive to industrial promotion and application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Put 10kg of marigold coarse powder into the reactor, add 20kg of petroleum ether at the same time, stir at 40°C for 2h, filter, put the filter cake into the reactor, add 20kg of petroleum ether at the same time, stir at 40°C for 2h, filter, Put the filter cake into the reactor, add 20kg of petroleum ether, stir at 40°C for 1 hour, filter, combine the three filtrates to obtain the extract, evaporate under reduced pressure at 55°C to obtain 2.4kg of liquid extract with a specific gravity of 1.2.

[0028] Add 2.4kg liquid extract in the reactor, and add 7.2kg mass fraction of 50% sodium hydroxide aqueous solution to carry out 2.5h saponification reaction, the saponified product obtained after the reaction is dissolved in 90% ethanol aqueous solution with mass fraction, and then filtered , the resulting filter cake was washed with 90% ethanol aqueous solution and then vacuum-dried to obtain 0.27kg lutein crude product. The lutein crude product was detected by chromatography ...

Embodiment 2

[0030] Put 10kg of marigold coarse powder into the reactor, add 17kg of petroleum ether at the same time, stir at 35°C for 2h, filter, put the filter cake into the reactor, add 17kg of petroleum ether at the same time, stir at 35°C for 2h, filter, Put the filter cake into the reactor, add 17kg of petroleum ether, stir at 35°C for 1 hour, filter, combine the three filtrates to obtain the extract, evaporate under reduced pressure at 60°C to obtain 2.2kg of liquid extract with a specific gravity of 1.3.

[0031] Add 2.3kg liquid extract into the reaction kettle, and add 6.6kg mass fraction of 45% sodium hydroxide aqueous solution to carry out 2.5h saponification reaction, the saponified product obtained after the reaction is dissolved in 90% ethanol aqueous solution with mass fraction, and then filtered , the obtained filter cake was washed with 90% ethanol aqueous solution by mass fraction and then vacuum-dried to obtain 0.26kg lutein crude product. The lutein mass fraction of th...

Embodiment 3

[0033] Put 10kg of marigold coarse powder into the reactor, add 19kg of petroleum ether at the same time, stir at 35°C for 2h, filter, put the filter cake into the reactor, add 19kg of petroleum ether at the same time, stir at 35°C for 2h, filter, Put the filter cake into the reactor, add 19kg of petroleum ether, stir at 35°C for 1 hour, filter, combine the three filtrates to obtain the extract, evaporate under reduced pressure at 60°C to obtain 2.3kg of liquid extract with a specific gravity of 1.3.

[0034] Add 2.3kg liquid extract into the reaction kettle, and add 6.6kg mass fraction of 45% sodium hydroxide aqueous solution to carry out 2.5h saponification reaction, the saponified product obtained after the reaction is dissolved in 90% ethanol aqueous solution with mass fraction, and then filtered , the resulting filter cake was washed with 90% ethanol aqueous solution by mass fraction and then vacuum-dried to obtain 0.28kg lutein crude product, which was detected by chromat...

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Abstract

The invention relates to a process for extracting xanthophyll from Tagetes erecta, and aims to provide a process which is used for extracting the xanthophyll from the Tagetes erecta and is simple to operate and suitable for industrial application. The process for extracting the xanthophyll from the Tagetes erecta comprises steps as follows: the Tagetes erecta is smashed; petroleum ether is used for extracting the xanthophyll; an extracting solution is subjected to reduced pressure concentration, and a fluid extract is obtained; the fluid extract is saponified, a saponifiable matter is dissolved in an ethanol solution and then filtered, and a filter cake is washed with the ethanol solution and then subjected to vacuum drying; and after a dried matter is mixed with an antioxidant, dichloromethane is used for recrystallization, an obtained crystal is subjected to vacuum drying, and a product is obtained. The process for extracting the xanthophyll from the Tagetes erecta is simple and facilitates industrial production; and the content of xanthophyll in a xanthophyll crude product washed with the ethanol solution is above 80%, the xanthophyll yield is above 35%, the content of the xanthophyll in the finally prepared product is above 95%, and the total yield of the xanthophyll is higher than 25%.

Description

technical field [0001] The invention relates to a process for extracting lutein, in particular to a process for extracting lutein from marigolds. Background technique [0002] Lutein is a "carotenoid" substance, its chemical name is 3'3-dihydroxy-α-carotene, and its molecular formula is C 40 h 56 0 2 . Lutein is insoluble in water, but easily soluble in oil and fatty solvents. Lutein not only inhibits cancer and delays arteriosclerosis, but also protects the eyes, reduces the incidence of cataracts, and prevents diabetic retinopathy. Tagetes erecta (scientific name Tagetes erecta) is an annual herb, belonging to Dicotyledoneae Asteraceae Tubular Flower Subfamily Tagetes genus Asteraceae Angiosperm Phylum. It contains a large amount of natural lutein and is very suitable for natural extraction of lutein. [0003] However, in the prior art, the extraction method for lutein in marigolds is more complicated to operate, as the application number is 201110030487.4 patent "a m...

Claims

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Application Information

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IPC IPC(8): C07C403/24
Inventor 胥敏
Owner XIAN LVSEN BIOTECH
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