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Application of swine mycoplasma pneumonia vaccine strain

A technology of mycoplasma pneumoniae and mycoplasma hyopneumoniae, which is applied to medical preparations containing active ingredients, bacterial antigen components, antibody medical components, etc., can solve problems affecting pig growth and feed conversion rate, destroying the mucosa-cilia barrier, and raising pigs To avoid problems such as economic losses in the industry, to achieve the effects of ensuring specificity and immune efficacy, reducing adverse reactions, and being easy to promote and apply on a large scale

Active Publication Date: 2014-02-19
JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After Mhp infects the body, it mainly adheres to the cilia on the inner wall of the respiratory tract, causing cilia cell lesions and apoptosis, causing cilia to break and fall off, causing disease in the body, and will seriously affect the growth and feed conversion rate of pigs, or destroy the mucosa-cilia barrier. It is easy to cause secondary infection of other pathogenic bacteria (especially for young pigs), increasing the lethality rate, thus causing huge economic losses to the pig industry
At present, the main prevention and treatment measures of swine mycoplasma pneumonia are vaccines and drugs, but effective drugs are lacking. Therefore, the development of vaccines for this disease will be of great significance for the prevention and control of this disease

Method used

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  • Application of swine mycoplasma pneumonia vaccine strain
  • Application of swine mycoplasma pneumonia vaccine strain
  • Application of swine mycoplasma pneumonia vaccine strain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1: The preparation method of the inactivated vaccine (NJ strain) of mycoplasma pneumoniae in swine.

[0029] 1 strain culture

[0030] Mycoplasma hyopneumoniae NJ strain was selected as the strain, which was isolated and identified by us and obtained after subculture. This strain was sent to the China Center for Type Culture Collection (CCTCC) on July 16, 2012, with the preservation number: CCTCCM2012286;

[0031] 2 strain characteristics

[0032] 2.1 Morphological and biochemical characteristics This bacterium is a Gram-negative polymorphic microorganism, which has ring, spherical, point, rod and bipolar shapes, is not easy to color, and has no cell wall. The biochemical characteristics should conform to the characteristics of the bacteria in bacterial taxonomy.

[0033] 2.2 Culture characteristics In the liquid culture medium (pH value 7.4-7.6), after cultured at 37°C for 3-7 days, the pH value will drop to 6.6-7.0, slightly uniform and turbid, and the titer...

Embodiment 2

[0061] Example 2: Observation of immune effect.

[0062] 1 vaccine

[0063] Mycoplasma pneumonia inactivated vaccine (NJ strain) oil adjuvant, Mycoplasma pneumonia inactivated vaccine (NJ strain) ISA11RVG, Mycoplasma pneumonia inactivated vaccine (NJ strain) Gel01ST, Mycoplasma pneumonia inactivated vaccine produced by a foreign company.

[0064] 2 strong poison for inspection

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Abstract

The invention relates to application of a swine mycoplasma pneumonia vaccine strain. The swine mycoplasma pneumonia vaccine strain No.NJ is classified and named as Mycoplasma hyopneumoniae, is preserved in China's typical culture collection center with a preservation number of CCTCC and the No. of M2012286 at July 16th, 2012. The drug is a vaccine. The inactivated vaccine provided by the invention is simple and convenient to produce, safe, reliable and excellent in protection effect, is equivalent to or superior to the existing commercial vaccines in the market as for the vaccine effect, and can effectively prevent prevalence of swine mycoplasma pneumonia.

Description

technical field [0001] The invention relates to the application of a swine mycoplasma pneumonia vaccine strain and belongs to the field of veterinary biological products. technical background [0002] Mycoplasma hyopneumoniae (Mhp) is the main pathogen that causes Mycoplasma pneumoniae of swine (Mps, also known as swine asthma), and is also an important primary pathogen of porcine respiratory disease syndrome. Mhp mainly infects the respiratory tract of pigs, and its pathogenicity is not strong. The clinical symptoms are mainly cough and wheezing. Meat sample" consolidation. After Mhp infects the body, it mainly adheres to the cilia on the inner wall of the respiratory tract, causing cilia cell lesions and apoptosis, causing cilia to break and fall off, causing disease in the body, and will seriously affect the growth and feed conversion rate of pigs, or destroy the mucosa-cilia barrier. It is easy to cause secondary infection of other pathogenic bacteria (especially for y...

Claims

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Application Information

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IPC IPC(8): A61K39/02A61K39/39A61P31/04
Inventor 刘茂军邵国青熊祺琰冯志新甘源韦艳娜白方方吴叙苏王占伟白昀王海燕王丽刘冬霞马庆红
Owner JIANGSU ACADEMY OF AGRICULTURAL SCIENCES
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