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Thesium granule with high stability and preparation method thereof

A technology of stability and granules, which is applied in the field of traditional Chinese medicine preparations, can solve the problems that the main component kaempferol is easy to degrade, not easy to take by patients with stomach problems, and the friability is not good, so as to improve accumulation and physical properties, stabilize granules, and improve brittleness. The effect of fragmentation

Active Publication Date: 2014-02-19
HONG KONG JOWA & HUAYUAN GRP CHUZHOU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The products already on the market include capsules and tablets, but these two dosage forms are suitable for children to take, and after the capsule dissolves in the stomach, it is easy to produce excessive local concentration, which increases the irritation, so it is not easy for patients with severe stomach problems take
[0007] Conventional barley preparations have the problems of poor stability, the main component kaempferol is easy to degrade, and the friability is not good. During the packaging process, the particles are easily broken

Method used

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  • Thesium granule with high stability and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Prepare the following raw materials:

[0036] Thyme 100Kg, micropowder silica gel 1Kg, sucrose 10Kg, dextrin 15Kg. The particle size of the micropowdered silica gel is between 300-400 mesh.

[0037] Prepare Bairui Granules according to the following steps:

[0038] S1: Take thyme grass and add ethanol water solution to decoct, add the ethanol water solution of 5 times the weight of the thyme grass for the first time, heat to reflux, decoct for 3 hours, add the ethanol water solution of 4 times the weight of the thyme grass for the second time, and heat Reflux and decoct for 2 hours;

[0039] S2: Filter the decoction, combine the filtrates, concentrate under reduced pressure, recover ethanol until the relative density is 1.22 (80°C), and let cool;

[0040] S3: Add water 5 times the weight of Thyme chinensis to the decoction obtained in step S2, and stir well; then add water 3 times the weight of Thyme chinensis, and stir well;

[0041] S4: Stand still for 16 hours, f...

Embodiment 2

[0046] Prepare the following raw materials:

[0047] Thyme 120Kg, micropowder silica gel 3Kg, sucrose 15Kg, dextrin 20Kg. The particle size of the micropowdered silica gel is between 300-400 mesh.

[0048] Prepare Bairui Granules according to the following steps:

[0049] S1: Take thyme grass and add ethanol water solution to decoct, add the ethanol water solution 8 times the weight of the thyme grass for the first time, heat to reflux, decoct for 1 hour, add the ethanol water solution 6 times the weight of the thyme grass for the second time, heat Reflux and decoct for 2 hours;

[0050] S2: Filter the decoction, combine the filtrates, concentrate under reduced pressure, recover ethanol until the relative density is 1.24 (80°C), and let cool;

[0051] S3: Add water 8 times the weight of Thyme chinensis to the decoction obtained in step S2, and stir well; then add water 4 times the weight of Thyme chinensis, and stir well;

[0052] S4: Stand still for 8 hours, filter the su...

Embodiment 3

[0057] Prepare the following raw materials:

[0058] Thyme 110 Kg, micronized silica gel 2 Kg, sucrose 12 Kg, dextrin 18 Kg. The particle size of the micropowdered silica gel is between 300-400 mesh.

[0059] Prepare Bairui Granules according to the following steps:

[0060] S1: Take thyme grass and add ethanol water solution to decoct, add the ethanol water solution of 7 times the weight of the thyme grass for the first time, heat to reflux, decoct for 2 hours, add the ethanol water solution of 5 times the weight of the thyme grass for the second time, and heat Reflux and decoct for 2 hours;

[0061] S2: Filter the decoction, combine the filtrates, concentrate under reduced pressure, recover ethanol until the relative density is 1.23 (80°C), and let cool;

[0062] S3: Add water 7 times the weight of Thyme chinensis to the decoction obtained in step S2, and stir well; then add water 4 times the weight of Thyme chinensis, and stir well;

[0063] S4: Stand still for 12 hours...

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Abstract

The invention provides a thesium preparation, in particular relates to a thesium granule, and belongs to the technical field of traditional Chinese medicament preparations. The thesium granule is prepared from the following raw materials in parts by weight: 100 to 120 parts of thesium chinensis, 1 to 3 parts of micro-powder silica, 10 to 15 parts of sucrose, and 15 to 20 parts of dextrin. The preparation method of the thesium granules is as follows: the thesium granule is granulated by a wet method, and an extraction process of performing alcohol extraction firstly and then performing water precipitation is adopted. According to the thesium granule with high stability and the preparation method thereof, the prescription and prescription process of the thesium granules are improved, so that the stability of flavonoid active ingredients of the granules is improved, and meanwhile, the friability of the prepared granules is also reduced; therefore, the granules in the processes of processing, packaging and transporting are stable and are not broken easily; meanwhile, the extraction rate of the active ingredients of the thesium is improved by improving the preparation process.

Description

[0001] technical field [0002] The invention provides a preparation of Bairui, in particular relates to its granule dosage form, and belongs to the technical field of traditional Chinese medicine preparations. [0003] Background technique [0004] Chinese herbal thyme grass (CHINSES BASTARDTOADFLAX HERB), the Chinese aliases are Lilacgrass, ground pomegranate, thin beard grass, a pine, accumulating herbs, pearl grass, Artemisia phoenix, Qinglongcao, coral grass, playing grass, stone rapeseed , Pine hair ginseng, Xiaocao and Baifengcao, etc., are collectively referred to as a variety of plant medicinal materials of the genus Thesium L. in the family Santalaceae. They are distributed in tropical and temperate regions. There are 8 species in my country, all of which are produced in all provinces; Thymus is the dried whole herb of Thyme (Thesium chinense Turcz.) or its variant T. chinense Turcz. var longipedunculatum Chu. [0005] Studies have found that thyme grass mainly co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/16A61K47/04A61K47/36A61K47/26A61P11/04A61P11/02A61P11/00A61P29/00
Inventor 管悦琴管习海吴兰霜
Owner HONG KONG JOWA & HUAYUAN GRP CHUZHOU PHARMA CO LTD
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