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Asarin pharmaceutical composition and preparation method of injection of asarin pharmaceutical composition

A technology of asarone and its composition, which is applied in the field of preparation of asarone pharmaceutical composition and its injection, can solve problems such as instability, and achieve the effects of improving safety, high drug loading, and improving content stability

Active Publication Date: 2014-02-05
深圳朗欧医药集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it is either unstable or contains ingredients harmful to humans,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A kind of asarone pharmaceutical composition injection,

[0017] Contains the following components: asarone 10g, soybean oil 50g, lecithin 30g, citric acid 60g, glycerin 30g, cysteine ​​hydrochloride 18g, water for injection 2L.

[0018] 1) Heat 1L of water for injection, then add citric acid, glycerin, and cysteine ​​hydrochloride to dissolve and obtain the aqueous phase for later use;

[0019] 2) dissolving Asarone and lecithin in 50 g of soybean oil and stirring to form a solution as the organic phase;

[0020] 3) After mixing the organic phase and the aqueous phase obtained in the above two steps evenly, add water for injection to the full amount, add 0.3% activated carbon for injection to the obtained pharmaceutical composition and stir for 30 minutes, after decarburization and filtration, 0.22um microporous membrane Carry out fine filtration, pack into vials or ampoules, obtain the Asarone injection of the present invention, the concentration of the injection is ...

Embodiment 2

[0022] A kind of asarone pharmaceutical composition injection,

[0023] Contains the following components: asarone 10g, soybean oil 100g, soybean lecithin 20g, citric acid 30g, glycerin 50g, cysteine ​​hydrochloride 10g, water for injection 1L.

[0024] Dissolve asarone and soybean lecithin in 100g soybean oil, heat to 60°C and stir until fully dissolved to obtain an organic phase; add the obtained organic phase to the aqueous solution in which citric acid, glycerin, and cysteine ​​hydrochloride have been dissolved to 1L , which is the pharmaceutical composition solution of the present invention; the obtained pharmaceutical composition solution is added with 0.3% activated carbon for injection and stirred for 30 minutes, after decarburization and filtration, the 0.22um microporous filter membrane is used for fine filtration, and then packed into vials or ampoules. The bottles were dissected, a total of 1,000 bottles. That is, the Asarone injection of the present invention has...

Embodiment 3

[0026] A kind of asarone pharmaceutical composition injection,

[0027] Contains the following components: asarone 10g, soybean oil 150g, soybean sphingomyelin 30g, citric acid 60g, glycerin 50g, cysteine ​​hydrochloride 18g, water for injection 3L.

[0028] Asarone and soybean sphingomyelin were dissolved in 150 g of soybean oil, stirred until fully dissolved to obtain an organic phase (when preparing a concentrated solution, PEG400 was also added to the organic phase). Add citric acid, glycerin, and cysteine ​​hydrochloride to the water for injection to the full amount as the water phase (if freeze-dried powder injection is prepared, lactose is dissolved in the water phase at the same time). The obtained pharmaceutical composition solution was added with 0.3% activated carbon for injection and stirred for 30 minutes. After decarbonization and filtration, fine filtration was performed with a 0.22um microporous filter membrane, and the solution was divided into vials or ampoul...

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Abstract

The invention relates to a pharmaceutical composition, and discloses an asarin pharmaceutical composition. The asarin pharmaceutical composition comprises the following components in parts by weight: 1 part of asarin, 5 to 15 parts of soybean oil, 2 to 3 parts of phospholipid, 3 to 6 parts of citric acid, 3 to 5 parts of glycerinum, and 1 to 2 parts of cysteine hydrochloride. The invention also discloses a method for processing an asarin injection using the pharmaceutical composition. By adopting the asarin pharmaceutical composition, the solubilization effect of the asarin injection can be improved, and the content stability can be raised. The asarin pharmaceutical composition solution is close to a true solution. The preparation method of the asarin injection is simple and applicable to industrial production.

Description

technical field [0001] The invention relates to a medicine combination medicine, in particular to a preparation method of an asarone medicine composition and an injection thereof. Background technique [0002] Asarone, also known as α-asarone or α-asarone, is the main active ingredient of the traditional Chinese medicine Shichangpu, and it can also be synthesized by chemical methods. Studies have found that Asarum has the effects of relieving asthma, relieving cough, eliminating phlegm, calming, spasmolytic, and anticonvulsant. Asthma: it can resist histamine and acetylcholine, relieve bronchospasm; cough: it has a strong inhibitory effect on the cough center; expectorant: it can increase airway secretions and dilute sputum; sedation: it can significantly reduce spontaneous activity without Inhibitory effect; antispasmodic: similar to aminophylline, it has the effect of relaxing bronchial smooth muscle; anticonvulsant: a-asarone can increase the point stimulation threshold ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/44A61K47/24A61K47/10A61K47/12A61K47/18A61K31/09A61P11/06A61P11/14A61P11/10A61P25/20A61P25/08
Inventor 邹翔
Owner 深圳朗欧医药集团有限公司
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