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Cefpodoxime axetil dispersible tablet and preparation method thereof

A technology of cefpodoxime axetil and dispersible tablets, which can be applied to medical preparations without active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., and can solve problems such as being unfavorable to industrialized production, complex preparation process, and many equipments. , to achieve the effect of good disintegration time limit, simple process and good content uniformity

Active Publication Date: 2016-04-13
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method uses many auxiliary materials, and the preparation process is complicated, and the equipment used is many, which is unfavorable for industrialized production

Method used

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  • Cefpodoxime axetil dispersible tablet and preparation method thereof
  • Cefpodoxime axetil dispersible tablet and preparation method thereof
  • Cefpodoxime axetil dispersible tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] prescription:

[0033]

[0034] Preparation:

[0035] 1) Take the above cefpodoxime axetil and pass through a 100-mesh sieve, and pass the auxiliary materials through a 80-mesh sieve respectively, and set aside.

[0036] 2) Put 350g of cefpodoxime axetil, 450g of microcrystalline cellulose, 75g of croscarmellose sodium, 2005g of polyethylene glycol, and 50g of magnesium stearate in a wet granulator and mix for 30 minutes, then place in a dry Granulate in a French granulator, then add 75g of croscarmellose sodium, 50g of magnesium stearate, and 5g of stevia, mix well, and press into tablets with a tablet machine.

Embodiment 2

[0038] prescription:

[0039]

[0040]

[0041] Preparation:

[0042] 1) Take the above cefpodoxime axetil and pass through a 100-mesh sieve, and pass the auxiliary materials through a 80-mesh sieve respectively, and set aside.

[0043] 2) Put 700g of cefpodoxime axetil, 900g of microcrystalline cellulose, 150g of sodium carboxymethyl starch, 20010g of polyethylene glycol, and 100g of magnesium stearate in a wet granulator and mix for 30 minutes, then put it in a dry granulator Medium granulation, then add 150g of sodium carboxymethyl starch, 100g of magnesium stearate, 5g of stevioside, mix evenly, and press into tablets with a tablet machine.

Embodiment 3

[0045] prescription:

[0046]

[0047] Preparation:

[0048] 1) Take the above cefpodoxime axetil and pass through a 100-mesh sieve, and pass the auxiliary materials through a 80-mesh sieve respectively, and set aside.

[0049] 2) Put 350g of cefpodoxime axetil, 450g of pregelatinized starch, 75g of croscarmellose sodium, 2005g of polyethylene glycol, and 50g of talcum powder in a wet granulator and mix for 30 minutes, then dry granulate Granulate in the machine, add 75g of croscarmellose sodium, 50g of talcum powder, and 5g of aspartame, mix evenly, granulate, and press into tablets with a tablet machine.

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Abstract

The invention discloses a cefpodoxime proxetil dispersible tablet which comprises the following raw materials in percentage by weight: 20-45 percent of cefpodoxime proxetil, 30-50 percent of filler, 5-15 percent of a disintegrating agent, 0.25-1.0 percent of a wetting agent, 0.25-1.5 percent of a flavoring agent and 5.0-15 percent of polyethylene glycol 200. The preparation method adopts a specific wetting agent, so as to improve mobility, dissolubility and uniformity in mixing of the product and facilitate the storage of the product, and after the product is stored for a period of time, no obvious changes occur. According to the invention, the cefpodoxime proxetil dispersible tablet is obtained through direct powder mixing, granulation and tabletting, and the preparation method is simple without any special equipment, and is suitable for industrial production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a cefpodoxime axetil dispersible tablet and a preparation method thereof. Background technique [0002] Cefpodoxime axetil is the third-generation oral broad-spectrum cephalosporin, which is hydrolyzed into cefpodoxime on the intestinal wall after oral administration and absorbed by the intestinal tract. Cefpodoxime has a broad-spectrum and powerful antibacterial effect and a long half-life, and is widely used in the treatment of respiratory tract, urinary tract, obstetrics and gynecology infectious diseases and suppurative otitis media. [0003] Cefpodoxime Proxetil (CPDX-PR) is the third-generation oral cephalosporin [0004] It was listed in Japan for the first time in 1990. Its structural feature is that the 7th position of the cephalosporin skeleton is connected with a methoxyiminothiazolyl group, the 3rd position is connected with a methoxymethyl group, and the 4...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K31/546A61K47/34A61P31/04
Inventor 刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
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