Oral care composition containing heat-resistant superoxide dismutase and growth factors

An oral care and superoxide technology, applied in the field of oral care, can solve the problems of unstable biological activity of superoxide dismutase, short active half-life, no heat-resistant superoxide dismutase, etc. Stability, the effect of expanding the range of use

Active Publication Date: 2013-12-25
LAFANG CHINA CO LTD
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  • Claims
  • Application Information

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Problems solved by technology

[0004] However, in the research, it was found that the application of superoxide dismutase in oral care has the following problems: first, the active half-life of superoxide dismutase is short (only a few hours) after entering cells; Activity may be affected by other matrices in oral products and may not be stable
[0008] At present, there have been relevant research reports on the use of superoxide dismutase or epidermal cell growth factor alone in oral care products; while there is no relevant application research report on heat-resistant superoxide dismutase, the combination of heat-resistant superoxide dismutase and epidermal cell There is no relevant research report on the application of growth factors in oral care products through liposome encapsulation

Method used

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  • Oral care composition containing heat-resistant superoxide dismutase and growth factors
  • Oral care composition containing heat-resistant superoxide dismutase and growth factors
  • Oral care composition containing heat-resistant superoxide dismutase and growth factors

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Embodiment Construction

[0026] The heat-resistant superoxide dismutase of the present invention is Fe-SOD extracted from an extreme thermophile (Aquifex pyrophilus), and its molecular weight is between 38700 and 40000. It has the following two characteristics: (1) It exhibits good thermal stability under high temperature conditions. When treated at 80°C for 1-2 hours, the enzyme activity remains above 95%, and when treated at 100°C for 1-2 hours, the enzyme activity remains (2) Maintain more than 90% of the enzyme activity in the range of pH4-11. The technology of fermenting high temperature resistant superoxide dismutase has obtained the national invention patent (Zl200510005207.9).

[0027] The liposome of the present invention may be composed of one or more of lecithin, cholesterol, ceramide and sphingomyelin. It can ensure the stability, biocompatibility, transdermal absorption and sustained release and controlled release effect of heat-resistant superoxide dismutase and epidermal growth factor....

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Abstract

The invention discloses an oral care composition having an antibacterial and anti-inflammatory function and a prevention and restoration effect. The effective components of the oral care composition comprise heat-resistant superoxide dismutase, epidermal growth factors and liposome. The heat-resistant superoxide dismutase has stability higher than that of ordinary superoxide dismutase and has the function of improving the gingival bleeding and red and swollen symptoms caused by a variety of oral problems; the epidermal growth factors have the functions of promoting wound healing of skin and mucosa, diminishing inflammation, relieving pain and preventing ulcer; the unilamelar liposome wraps the heat-resistant superoxide dismutase and the epidermal growth factors to ensure more durable biological activity and has targeting and transdermal absorption properties.

Description

technical field [0001] The invention relates to the field of oral care, in particular to an oral care composition in which liposomes encapsulate heat-resistant superoxide dismutase and epidermal growth factor. Background technique [0002] Superoxide dismutase (SOD for short) is a protein rich in metal ions, widely present in animal, plant, microbial cells or organelles. According to the different metal prosthetic groups it contains, it can be divided into three categories; the first category contains Cu and Zn (Cu-Zn-SOD for short), which mainly exists in the cytoplasm of eukaryotic cells; the second category contains Mn (Mn-SOD ), which exist in the mitochondria of eukaryotic cells and prokaryotic cells; the third type contains Fe (Fe-SOD), which only exists in prokaryotes. In 1969, Mc Cord and Fridovich purified and clarified the enzymatic characteristics and main biological functions of bovine red blood cell superoxide dismutase. Different types and different sources o...

Claims

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Application Information

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IPC IPC(8): A61K38/44A61K9/127A61K8/66A61K8/64A61K8/14A23G3/44A61P1/02A61Q11/00A61K38/18
Inventor 田俊
Owner LAFANG CHINA CO LTD
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