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Ampicillin capsule and preparation method thereof

A technology of ampicillin capsules and ampicillin, applied in the field of ampicillin capsules and its preparation, can solve the problems of increasing the chance of water contact with the external environment, not improving the stability of ampicillin, and easy increase of polymers, etc., to improve drug solubility , Improve the dissolution rate and improve the stability

Active Publication Date: 2013-12-25
吉林显锋科技制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the dissolution rate of homoampicillin after micronization is improved to a certain extent, it does not improve the stability of ampicillin. On the contrary, due to the increase of surface area, the chance of contact with moisture in the external environment is increased, and the polymer is more likely to increase.

Method used

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  • Ampicillin capsule and preparation method thereof
  • Ampicillin capsule and preparation method thereof
  • Ampicillin capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Embodiment 1 Ampicillin capsules and preparation technology thereof

[0021]

[0022] Preparation process: Pass ampicillin through a 100-mesh sieve, tartaric acid through a 100-mesh sieve, and mix well. Add absolute ethanol solution to the uniformly mixed granules, granulate, sieve through a 16-mesh sieve, dry at 50°C, mix the dry granules with magnesium stearate evenly, and fill the capsules.

Embodiment 2

[0023] Embodiment 2 ampicillin capsules and preparation technology thereof

[0024]

[0025] Preparation process: Pass ampicillin through a 120-mesh sieve, tartaric acid through a 120-mesh sieve, and mix well. Add the absolute ethanol solution to the uniformly mixed granules, granulate, sieve through a 18-mesh sieve, dry at 55°C, mix the dry granules with magnesium stearate evenly, and fill the capsules.

Embodiment 3

[0026] Embodiment 3 ampicillin capsules and preparation technology thereof

[0027]

[0028] Preparation process: Pass ampicillin through a 100-mesh sieve, tartaric acid through a 100-mesh sieve, and mix well. Add the absolute ethanol solution to the uniformly mixed granules, granulate, sieve the granules through a 18-mesh sieve, dry at 45°C, mix the dry granules with magnesium stearate evenly, and fill the capsules.

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Abstract

The invention discloses an ampicillin capsule and a preparation method thereof. The formulation is formed by uniformly mixing a drug-containing granule and a lubricating agent and then filling into a capsule shell; the drug-containing granule comprises the following components in parts by weight: 1 part of ampicillin and 0.1-0.5 part of tartaric acid, and the drug-containing granule is obtained by screening and uniformly mixing the ampicillin and the tartaric acid and then adopting a wet method for granulation. The ampicillin capsule disclosed by the invention has the advantages of fast dissolution, good stability, less auxiliary material variety and simple preparation process.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an ampicillin capsule and a preparation method thereof. Background technique [0002] Ampicillin is a semi-synthetic broad-spectrum penicillin, which is widely used clinically, and is commonly used in the treatment of infections caused by sensitive bacteria such as Gram-positive and negative bacteria, including upper respiratory tract infections, genitourinary system infections, skin and soft tissue infections, and lower respiratory tract infections , Acute simple gonorrhea and so on. Oral ampicillin preparations have various dosage forms such as capsules, tablets, granules, dry suspensions, dispersible tablets, chewable tablets, etc. Among them, capsules account for more than 70% of the market share. However, what currently plagues researchers is that ampicillin will undergo penicillin degradation reactions, and at the same time, because the carbonyl of the β-lacta...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/12A61K31/43A61P31/04
Inventor 不公告发明人
Owner 吉林显锋科技制药有限公司
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