Preparation method of porous polymer microspheres

Abstract

The invention provides a preparation method of porous polymer microspheres. The preparation method comprises the following steps: mixing an oil soluble monomer, a cross-linking agent and an emulsifying agent to obtain an oil phase; mixing the oil phase with water to obtain double emulsion; and performing polymerization reaction on the double emulsion to obtain the porous polymer microspheres. According to the preparation method of the porous polymer microspheres, the double emulsion is high in stability, so that an electrolyte and a stabilizer are not needed for improving the stability of the double emulsion; the polymerized porous polymer microspheres are high in yield and have regular shape and high pore connectivity; the microspheres are high in size monodispersity and wide in size adjustment range; and the finally obtained product is simple to process.

Description

technical field [0001] The invention relates to the field of porous microsphere materials, in particular to a preparation method of porous polymer microspheres. Background technique [0002] High Internal Phase Emulsion (High Internal Phase Emulsion, HIPE) refers to the emulsion whose volume fraction of the internal phase (dispersed phase) is more than 74%. microporous) porous material. This material has good application prospects. For example, due to its high specific surface area, it can be used as a catalyst carrier or as a catalyst itself; it has adjustable pore size and can be used in the field of separation and filtration; in addition, porous materials can be used in tissue cell culture, drug release, etc. and other biological fields have good prospects. [0003] High internal phase emulsions can be divided into water-in-oil (W / O) type and oil-in-water (O / W) type. Depending on the nature of the monomer, the types of emulsions that are suitable are also different. Am...

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Problems solved by technology

Due to the continuous phase polymerization, the shape of the high internal phase polymer porous material (polyHIPEs) obtained after polymerization is consistent with the shape of the reactor. For example, a test tube as a reactor will obtain a cylindrical block material, which is not conducive to The removal of impurities such as unpolymerized monomers, emulsifiers, and electrolytes in the system is also inconvenient in practical applications

[0005] U.S. Patent Application No. 5,583,162 reported that the high internal phase emulsion was transferred to molds of different shapes, and millimeter-scale porous balls in shapes such as spheres, ellipses, and cylinders were obtained, but the mold design and manufacturing costs of this method were too high. The smallest size can only be controlled to a few millimeters; (React.Funct.Polym.2005,65,37) and Krajnc et al. (React.Funct.Polym.2005,65,37) first prepared the water-in-oil (W / O) reverse phase high internal phase emulsion containing chlorostyrene, and then dispersed the high internal phase emulsion into the PVP aqueous solution , resuspension polymerization to obtain polyHIPEs porous polymer microbeads

But the disadvantage of this method is that the high internal phase emulsion is a high viscosity emulsion, it is difficult to disperse it, even if it can be dispersed, it is difficult to form a regular spherical shape, and the internal water phase contains electrolytes, and the internal and external water phases form osmotic pressure. The double emulsion that causes formation is unstable; Gokmen et al. (Macromolecules2009,42,9289) disperses the prepared inverse high internal phase emulsion into PVA aqueous solution by microfluidic technology, and obtains porous polymer particles (spheres and rods) by UV-induced polymerization. )

However, the microfluidic technology used can only be realized in the laboratory at present, and it is difficult to apply it to actual industrial production.

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