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Lactic acid-ethanol copolymer microsphere with modified surface and preparation method thereof

A glycolic acid copolymer and surface modification technology, which can be used in the preparation of microspheres, microcapsule preparations, medical preparations of inactive ingredients, etc., can solve problems such as clinical application obstacles, and achieve good size monodispersity and uniform size. , good biocompatibility

Active Publication Date: 2010-05-12
WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

Although a large number of studies have confirmed the feasibility of this topic, there are still great obstacles to the actual clinical application, for example, whether the choice of drug delivery system is safe and effective, and whether the grafted active target recognition can be regenerated.

Method used

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Examples

Experimental program
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Embodiment Construction

[0010] The present invention will be described in further detail below according to the examples.

[0011] A surface-modified lactic acid-glycolic acid copolymer microsphere, the basic composition of its formula is as follows: (the following is calculated by mass percentage) lactic acid-glycolic acid copolymer (PLGA): 90% to 97%; stabilizer ( polyether): 3% to 10%; target substance: 0.01% to 0.1%.

[0012] In the lactic acid-glycolic acid copolymer, the mass percentage of lactic acid and glycolic acid is 85:15-40:60, and the weight-average molecular weight is 30,000-300,000; the stabilizer is polypropylene glycol and polyethylene oxide. The triblock copolymer of alkane is in the form of PEO-PPO-PEO, wherein the mass percentage of polypropylene glycol and polyethylene oxide is 90:10-50:50, and the weight-average molecular weight is 10,000-50,000; the described The target is a biological agent with biological targeting and localization, which can be immunoglobulin, or cadaverin...

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Abstract

The invention relates to a lactic acid-ethanol copolymer microsphere with a modified surface, which comprises the following components in percentage by weight: 90-97 percent of lactic acid-ethanol copolymer, 3-10 percent of stabilizer and 0.01-0.1 percent of target substance. A preparation method of the lactic acid-ethanol copolymer microsphere with the modified surface comprises the following steps of: taking a certain amount of conventionally prepared PLGA microspheres, drying, soaking in water solution containing the stabilizer, adding a proper amount of bridging agent and the target substance, reacting at 4 DEG C for 12h, steaming at room temperature to remove moisture, washing with ethanol three times, and drying to obtain the lactic acid-ethanol copolymer microsphere material with the modified surface. The invention has the advantages that the prepared lactic acid-ethanol copolymer microsphere with the modified surface has favorable biocompatibility, biodegradability and bioresorbable property, and can be used as a target medicament carrier; the preparation method is simple and effective; and the prepared polyester microspheres have uniform size and good size monodispersity.

Description

technical field [0001] The invention relates to the field of biocompatible polymer microsphere materials, in particular to a surface-modified lactic acid-glycolic acid copolymer microsphere and a preparation method thereof. Background technique [0002] The targeted release of drugs is the most challenging research topic in the field of biotherapeutics in recent years. The targeted release of drugs to the target area can effectively increase the drug concentration and reduce the side effects on healthy tissues. This topic is more important for insoluble hydrophobic substances in the body, highly active drugs for the treatment of cancer, and biologically derived proteins, amino acids, nucleosides, etc. for important. The use of microspheres or submicron particles can be used as drug carriers due to the particularity of size and structure. In addition, if the surface of the microspheres is connected with biological recognition ligands, the specific release of drugs can be ach...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/34A61K47/42A61K9/16B01J13/04C08G63/91A61K47/10
Inventor 韩志超许杉杉申孟芝李立藏
Owner WUXI ZHONGKE GUANGYUAN BIOMATERIALS
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