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Preparation method of near-infrared light response hydrogel

A near-infrared light-responsive, hydrogel technology is applied in the preparation of hydrogels and the preparation of light-stimulated-responsive hydrogels, which can solve the problems of rapid diffusion and unfavorable treatment, achieve a large selection range and enhance international competitiveness. , conducive to the effect of repeated use

Active Publication Date: 2013-11-27
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this type of inorganic material needs to be injected into the body through subcutaneous injection. After injection, the inorganic and inorganic nanoparticles will diffuse rapidly in the subcutaneous area, which is not conducive to the treatment.

Method used

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  • Preparation method of near-infrared light response hydrogel
  • Preparation method of near-infrared light response hydrogel
  • Preparation method of near-infrared light response hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Add 10g of polyethylene glycol to 100g of deionized water, stir and disperse, add 0.5g of copper sulfate pentahydrate and 2g of sodium sulfide respectively, and pre-react for 1 hour to obtain a mixed dispersion; then transfer the above mixed dispersion to a hydrothermal kettle , at 120°C, reacted for 12 hours; after the reaction was completed, cooled to 30°C, washed with deionized water, and dried to obtain copper sulfide powder.

[0029] Add 0.02g of polyethylene glycol diacrylate, 2g of N-isopropylacrylamide, 0.01g of copper sulfide powder, 0.02g of ammonium persulfate, and 0.01g of sodium thiosulfate into 10g of deionized water to obtain a hydrogel prepolymerized liquid. The hydrogel pre-polymerization solution was polymerized at 25° C. for 8 hours to obtain a near-infrared light-responsive hydrogel. Under the irradiation of near-infrared light with a wavelength of 808 nm, the temperature of the hydrogel can increase by 20 °C within 10 minutes.

Embodiment 2

[0031] Add 20g of polyethylene glycol to 100g of deionized water to stir and disperse, add 0.4g of anhydrous copper chloride and 4g of ammonium sulfide respectively, and pre-react for 2 hours to obtain a mixed dispersion; then transfer the above mixed dispersion to a hydrothermal kettle , at 150°C, reacted for 8 hours; after the reaction was completed, cooled to 30°C, washed with deionized water, and dried to obtain copper sulfide powder.

[0032] Add 0.02g of polyethylene glycol diacrylate, 2g of acrylamide, 0.01g of copper sulfide powder, 0.02g of ammonium persulfate, and 0.02g of sodium thiosulfate into 10g of deionized water to obtain a hydrogel prepolymer solution. The hydrogel pre-polymerization solution was polymerized at 25° C. for 8 hours to obtain a near-infrared light-responsive hydrogel. Under the irradiation of near-infrared light with a wavelength of 808 nm, the temperature of the hydrogel can increase by 20 °C within 10 minutes.

Embodiment 3

[0034] Add 10g of polyvinylpyrrolidone into 100g of deionized water, stir and disperse, add 0.5g of copper sulfate pentahydrate and 2g of sodium sulfide respectively, and pre-react for 1 hour to obtain a mixed dispersion; then transfer the above mixed dispersion to a hydrothermal kettle, React at 150°C for 12 hours; after the reaction is over, cool to 40°C, wash with deionized water, and dry to obtain copper sulfide powder.

[0035] Add 0.02g of polyethylene glycol dimethacrylate, 2g of N-isopropylacrylamide, 0.02g of copper sulfide powder, 0.02g of sodium persulfate, and 0.05g of triethanolamine into 10g of deionized water to obtain a hydrogel prepolymerized liquid. The hydrogel pre-polymerization liquid was polymerized at 25° C. for 24 hours to obtain a near-infrared light-responsive hydrogel. Under the irradiation of near-infrared light with a wavelength of 980nm, the temperature of the hydrogel can increase by 40°C within 10 minutes.

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Abstract

The invention relates to a preparation method of near-infrared light response hydrogel. The method comprises the following steps: (1) adding a ligand into deionized water, stirring for dispersion, adding a soluble copper salt and a sulfate, carrying out a pre-reaction to obtain a mixed dispersion liquid, and enabling the mixed dispersion liquid to react for 8-24 hours to obtain copper sulfide; and (2) adding a cross-linking agent, a water soluble monomer, the copper sulfide obtained in the step (1), an initiator, and a catalyst into the deionized water to obtain a hydrogel polymerization liquid, and enabling the hydrogel polymerization liquid to polymerize at 0-50 DEG C for 1-48 hours to obtain the near-infrared light response hydrogel. The preparation method provided by the invention is simple in preparation process and large in raw material selection range; the temperature of the hydrogel under the radiation of the near-infrared light within the wavelength of 700-1100nm can be obviously increased, and therefore the hydrogel is high in application value; the method is simple in process, wide in raw material sources and quite low in cost, and has a high application value in the fields of thermal therapy treatment or intelligent devices.

Description

technical field [0001] The invention belongs to the field of preparation of light-stimulus-responsive hydrogels, and in particular relates to a preparation method of near-infrared light-responsive hydrogels. Background technique [0002] Hydrogel is a soft-wet material with a three-dimensional network crosslinked structure composed of hydrophilic polymers and solvent water. Hydrogel has the property that solids cannot flow macroscopically, and can be used as a space for stable dispersion of inorganic materials. It is of great significance to introduce functional inorganic materials into the hydrogel matrix and design them to have properties similar to those of functional inorganic materials while still maintaining the unique properties of the hydrogel itself. [0003] Cancer poses a serious threat to human health. Since the end of the last century, malignant tumors have risen to the No. 1 cause of death among urban residents. At present, the main methods for treating cancer...

Claims

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Application Information

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IPC IPC(8): C08F290/06C08F220/54C08F220/56C08F222/38C08F220/28C08F2/44C08K9/04C08K3/30A61K41/00A61K9/06A61P35/00
Inventor 朱美芳夏梦阁许文菊陈志钢成艳华
Owner DONGHUA UNIV
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