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Au(111)-like nano-particle non-enzyme glucose sensor electrode, and preparation method and application of same

A glucose sensor and nanoparticle technology, applied in the direction of electrochemical variables of materials, etc., to achieve the effects of good market value, good selectivity, and short preparation time

Inactive Publication Date: 2013-11-20
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of detection limit, the detection limit of the gold nanocolumn enzyme-free glucose sensor reported in the literature is only 60 μM; the detection limit of the gold disc enzyme-free glucose sensor is only 10 μM

Method used

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  • Au(111)-like nano-particle non-enzyme glucose sensor electrode, and preparation method and application of same
  • Au(111)-like nano-particle non-enzyme glucose sensor electrode, and preparation method and application of same
  • Au(111)-like nano-particle non-enzyme glucose sensor electrode, and preparation method and application of same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] (1) Pretreatment of conductive substrate:

[0034] Wipe the indium tin oxide (ITO) conductive glass with ethanol first, and then ultrasonically clean it with acetone, isopropanol, and ultrapure water for 20 minutes. Then put it into a mixture of deionized water, ammonia water (mass concentration 25%-28%) and hydrogen peroxide (mass concentration 30%), wherein the volume ratio of ionized water, ammonia water and hydrogen peroxide is 5:1:1, After heating and boiling for 30 minutes, wash with ultrapure water, blow dry with high-purity nitrogen, and set aside.

[0035] (2) Preparation of enzyme-free glucose sensor electrodes:

[0036]In 40mL electrolyte composed of 0.1mol / L sodium perchlorate and 0.0001mol / L chloroauric acid, ITO conductive glass is used as working electrode, platinum sheet is used as counter electrode, saturated calomel electrode is used as reference electrode, ITO electrode is The area is 0.4cm 2 . Before deposition, it can be blown with high-purity n...

Embodiment 2

[0038] (1), pretreatment of conductive substrate: same as embodiment 1

[0039] (2) Preparation of enzyme-free glucose sensor electrodes:

[0040] In 40mL electrolyte composed of 0.1mol / L sodium perchlorate and 0.0001mol / L chloroauric acid, ITO conductive glass is used as working electrode, platinum sheet is used as counter electrode, saturated calomel electrode is used as reference electrode, ITO electrode is The area is 0.4cm 2 . Before deposition, it can be blown with high-purity nitrogen for 30 minutes to remove dissolved oxygen in the electrolyte, and then use chronoamperometry to jump from the open circuit potential of 0.74V to -0.8V for 10s, and then use cyclic voltammetry at - Scan 500 cycles within the potential range of 0.04 to +0.3V, further electrodeposit the ITO electrode, wash the ITO electrode with deionized water, store it in deionized water, and store it at 4°C for later use.

[0041] figure 1 It is a low-resolution field emission scanning electron microsc...

Embodiment 3

[0047] (1), pretreatment of conductive substrate: same as embodiment 1

[0048] (2) Preparation of enzyme-free glucose sensor electrodes:

[0049] In 40mL electrolyte composed of 0.1mol / L sodium perchlorate and 0.0001mol / L chloroauric acid, ITO conductive glass is used as working electrode, platinum sheet is used as counter electrode, saturated calomel electrode is used as reference electrode, ITO electrode is The area is 0.4cm 2 . Before deposition, it can be blown with high-purity nitrogen for 30 minutes to remove dissolved oxygen in the electrolyte, and then use chronoamperometry to jump from the open circuit potential of 0.74V to -0.8V for 10s, and then use cyclic voltammetry at - Scan 300 cycles within the potential range of 0.04 to +0.3V, further electrodeposit the ITO electrode, wash the ITO electrode with deionized water, store it in deionized water, and store it at 4°C for later use.

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Abstract

The invention belongs to the technical field of electrochemical sensors, and in particular relates to an Au(111)-like nano-particle modified non-enzyme glucose sensor electrode, and a preparation method and application of the same. The preparation method comprises the following steps of: firstly, wiping a conductive substrate with alcohol, then, respectively performing ultrasonic washing with acetone, isopropyl alcohol and ultrapure water, adding the conductive substrate in the mixed liquor of deionized water, ammonia water and hydrogen peroxide, heating until boiling, finally, cleaning the conductive substrate with the ultrapure water and blowing the conductive substrate to dry with nitrogen; in the electrolyte solution composed of sodium perchlorate and chloroauric acid solution, firstly, performing electrolytic deposition on the conductive substrate by means of chronoamperometry, then, further performing electrolytic deposition on the conductive substrate by means of cyclic voltammetry, and cleaning the conductive substrate with the deionized water. The non-enzyme glucose sensor electrode is very sensitive to the concentration variation of the glucose and presents better linear relation, moreover, the non-enzyme glucose sensor electrode has better selectivity to the glucose, only needs 1.5s response time to the glucose and can achieve the detection limit of 5mu moL / L.

Description

technical field [0001] The invention belongs to the technical field of electrochemical sensors, and in particular relates to an enzyme-free glucose sensor electrode modified by Au(111) nanoparticles, a preparation method thereof, and an application in glucose detection. Background technique [0002] Gold nanoparticles have unique optical and electrical properties, good catalytic activity, excellent bio-affinity and nonlinear optical properties. This kind of inorganic nanoparticles can be used as structural and functional units to construct various two-dimensional or three-dimensional supercrystals. The lattice structure has broad application prospects in bioelectrochemical sensors, photochemical sensors, electronic nanodevices, etc., and has aroused great interest of scientific and technological workers. So far, gold nanomaterials with different shapes have been prepared, such as nanowires, nanorods, and flower-like nanoparticles. At the same time, different preparation met...

Claims

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Application Information

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IPC IPC(8): G01N27/30C25D3/48C25D5/00
Inventor 曹晓卫王俊刚李玲
Owner SHANGHAI NORMAL UNIVERSITY
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