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Wound healing dressing containing carrageenan, and preparation method and application of wound healing dressing

A technology of wound repair and carrageenan, which is applied in the field of biomedical materials, can solve the problems of not using carrageenan, achieve the effect of close skin tensile strength, convenient use and operation, and accelerate the formation of tissue

Active Publication Date: 2015-03-04
GUANGZHOU ANZE REGENERATIVE MEDICINE TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] None of the materials used in the existing wound repair technology uses carrageenan and its derivatives. In view of the gel-forming properties of carrageenan, some patents involve carrageenan as capsules, viscosifying dressings or as cell encapsulation.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] 1. Preparation of carrageenan / collagen porous composite scaffold:

[0034] (1) Swell type I collagen with a concentration of 0.05M acetic acid solution to obtain a type I collagen swelling solution with a mass concentration of 0.4%, then mix it with a K-type carrageenan solution with a mass concentration of 2%, and heat at 40°C , Stirring at 4000 rpm for half an hour to obtain a blended solution; wherein the mass ratio of collagen to carrageenan is 1:4;

[0035] (2) Centrifuge and degas the blended solution obtained in step (1) (1500 rpm, 5 minutes) and then pour it into a mold for molding (making the height of the mixed solution in the mold 7 mm), and then put the mold at -20 After freezing in a refrigerator at ℃ for 2-5 hours, place the mold in a freeze dryer at a freezing temperature of -50℃, freeze for 2 hours, and then pump it under vacuum at 0℃ for 24 hours to obtain a carrageenan / collagen porous composite scaffold.

[0036] The prepared carrageenan / collagen poro...

Embodiment 2

[0039] 1. Preparation of carrageenan / collagen composite film:

[0040] (1) Swell type I collagen with a concentration of 0.04M acetic acid solution to obtain a type I collagen swelling solution with a mass concentration of 0.35%, then mix it with a type I carrageenan solution with a mass concentration of 4%, and heat at 30°C , Stirring at 4000 rpm for half an hour to obtain a blended solution; wherein the mass ratio of collagen to carrageenan is 1:1;

[0041] (2) Centrifuge and degas the blended solution obtained in step (1) (1000 rpm, 4 minutes) and pour it into a mold for molding (making the height of the mixed solution in the mold 4mm), and then place the mold on the drum In an air dryer, after drying at a temperature of 60°C for 72 hours, a carrageenan / collagen composite film can be obtained.

[0042] The prepared carrageenan / collagen composite film has a thickness of about 2-3 mm, and is sterilized by ethylene oxide for use.

[0043] 2. Effect experiment of carrageenan / ...

Embodiment 3

[0045] 1. Preparation of carrageenan / collagen porous composite scaffold:

[0046] (1) Swell type I collagen with 0.05M acetic acid solution to obtain a collagen swelling solution with a mass concentration of 0.45%, then mix it with a 2% L-type carrageenan solution, and heat at 30°C, 4000 RPM and stirring for half an hour to obtain a blended solution; wherein the mass ratio of collagen to carrageenan is 2:1;

[0047] (2) Centrifuge and degas the blended solution obtained in step (1) (1500 rpm, 5 minutes) and pour it into a mold for molding (make the height of the mixed solution in the mold be 6 mm), and put the mold in the refrigerator ( Freeze at -20°C for 3 hours; then place the mold in a freeze dryer, freeze at -30°C for 2 hours, and then pump it under vacuum at 0°C for 24 hours to obtain a carrageenan / collagen porous composite scaffold.

[0048] The prepared porous composite scaffold has a diameter of 0.6 cm and a thickness of 3-4 mm, and is sterilized by ethylene oxide fo...

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Abstract

The invention discloses a wound healing dressing containing carrageenan, and a preparation method and application of the wound healing dressing. The wound healing dressing is a porous composite stent with a three-dimensional porous interlayer structure, or a composite thin film, wherein the porous composite stent is obtained by blending collagen or gelatin with carrageenan in a mass ratio of (5: 95) to (95: 5) and then freeze-drying the mixture, and the composite thin film is obtained by directly drying the mixture after blending. The wound healing dressing disclosed by the invention is capable of guaranteeing nutrition supply required by tissues for normal healing, and can be degraded and disappear after the tissues are healed; simultaneously, the degradation product has the effects of promoting cell proliferation and matrix expression, and truly achieving the effect of wound healing. Besides, the porous composite stent and the composite thin film both are capable of providing a stent for other soft tissue engineering while promoting wound healing. The wound healing dressing disclosed by the invention is wide in use; specifically, the wound healing dressing can be used for healing large skin wounds caused by burn or anabrosis, and also can be used as tissue engineering stent materials such as cartilage, cornea and fat; or, the wound healing dressing can be used for other fields such as clinical medicine.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a wound repair dressing containing carrageenan, a preparation method and application thereof. Background technique [0002] Carrageenan (Carrageenan), also known as carrageenan and carrageenan, is a water-soluble colloid extracted from red algae (Red aglae, Rhodophyta). , alginate). As a natural food additive, carrageenan has been used in the food industry for decades. The United Nations Food and Agriculture Organization and the World Health Organization Food Additives Expert Committee (JECFA, Joint FAO / WHO Expert Committee on Food Additives) canceled the limit of carrageenan daily intake (ADI, Acceptable Daily Intake) in 2001, confirming that it is a Food additives that are safe, non-toxic and have no side effects. According to statistics, the global production of carrageenan is increasing at a rate of 3%, and the global sales volume in 2000 reached 310 million...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/32A61L15/28A61L15/42A61L27/24A61L27/20A61L27/56
Inventor 汤顺清易静楠王小莺毛萱
Owner GUANGZHOU ANZE REGENERATIVE MEDICINE TECH CO LTD
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