Fenticonazole nitrate and synthesis process thereof
A technology of fenticonazole nitrate and concentrated ointment, which is applied in the field of medicine, can solve the problems of easy repetition and slow onset, and achieve the effects of reducing toxicity and corrosion, short cycle time and high yield
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Embodiment 1
[0048] A kind of fenticonazole nitrate is characterized in that it is prepared by the following weight ratio raw materials,
[0049] 20 parts of Fenticonazole Nitrate, 50 parts of Liangmianzhen, 50 parts of Baibu, 40 parts of Poria, 40 parts of Papaya, 40 parts of Dandelion, 35 parts of Tangerine Peel, 30 parts of Banxia, 30 parts of Mulberry, 25 parts of Safflower, 25 parts of Hawthorn 20 parts, Lingxiaohua 20 parts, turmeric 20 parts, Angelica dahurica 15 parts, pomegranate peel 15 parts.
[0050] The synthetic technique of compound recipe fenticonazole nitrate of the present invention is:
[0051] (1) Take 20 grams of fenticonazole nitrate, 50 grams of liangmianzhen, 50 grams of Baibu, 40 grams of poria cocos, 40 grams of papaya, 40 grams of dandelion, 35 grams of tangerine peel, 30 grams of pinellia, 30 grams of mulberry, and 25 grams of safflower. 25 grams of hawthorn, 20 grams of Ling Xiaohua, 20 grams of turmeric, 15 grams of Angelica dahurica, and 15 grams of pomegr...
Embodiment 2
[0056] Toxicology research
[0057] 1 Acute toxicity test:
[0058] Divide 30 rabbits into 3 groups at random, 10 in each group, half male and half male, use 10% sodium sulfide to depilate the back of the rabbits, the depilatory area is about 150cm 2 . The making of damaged skin adopts sterilized iron file to scratch (taking blood as the degree), applies suppository of the present invention 0.2,0.4 and 0.8ml respectively in the depilatory area after depilation and fixes with non-irritating adhesive plaster, and every animal is divided into cages and raised From 1, 24, 48, 72 hours after 24 hours of administration to the seventh day, observe and record the changes of the animal's body weight, fur, luster, diet, eyes and mucous membranes, respiratory center, nervous system, limb activities and death every day After seven days, the rabbits were killed, and the changes in the heart, liver, spleen, lung, kidney and other organs were observed by dissection.
[0059] Results: The ...
Embodiment 3
[0074] clinical information
[0075] Clinical data: A total of 150 outpatients with complete medical records were selected. According to the "Guiding Principles for Clinical Research of New Drugs (Chinese Medicine) Vaginitis Diagnosis and Treatment Standards", the diagnosis was confirmed by vaginal secretion examination, including 58 cases of trichomonas vaginitis, 72 cases of fungal vaginitis, 11 cases of bacterial vaginosis, and trichomonas and fungus combined 9 cases were infected.
[0076] Test method: Example 1 prepares the compound medicine, administers it vaginally, starts to take medicine 2-3 days after menstruation is clean, 1 tablet each time, (medication is forbidden during menstrual period) 7 days is a course of treatment, each reexamination 1 time after each menstrual period , Other vaginitis can be used except for menstruation, and sexual intercourse is forbidden during treatment.
[0077] Evaluation criteria for curative effect: refer to the "Guidelines for Cl...
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