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Active attapulgite medicine and preparation method for same

An attapulgite and active technology, applied in the field of medicine, can solve the problems of unstable quality of attapulgite, unsuitable application of attapulgite to the pharmaceutical and food industries, unexpressed process parameters, etc.

Active Publication Date: 2013-09-25
SHANDONG SBOND PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent document CN100579903C (200710060489.1) discloses a purification and processing method of attapulgite clay minerals, and Chinese patent document CN1248984C (200410014477.1) discloses a high-purity attapulgite and its preparation method, but the two methods utilize Chemical reagents achieve the effect of separating attapulgite, resulting in attapulgite containing a large amount of harmful chemicals, and the purified attapulgite is not suitable for use in the pharmaceutical and food industries
Chinese patent document CN1121863C (98124462.9) discloses a preparation method of medicinal attapulgite. During the process of producing attapulgite, each production step does not describe the process parameters and the control index of the intermediate of the material in each link. In particular, the method for processing cristobalite is not described, and the attapulgite activation temperature control index is not described, so that the production process cannot be controlled, resulting in unstable quality of the attapulgite
[0010] There are various defects in the attapulgite purification process in the above prior art, and controlling the cristobalite content in attapulgite is the key to the application of attapulgite in the medical field. Technical disclosure of controlling the content of stone

Method used

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  • Active attapulgite medicine and preparation method for same
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  • Active attapulgite medicine and preparation method for same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] Embodiment 1, an active attapulgite medicine for treating diarrhea and flatulence gas gastrointestinal diseases, the preparation method steps are as follows:

[0086] (1) Dry the attapulgite clay with a heated drum dryer, the drum speed is controlled at 20r / min, the drying temperature is 130°C, and dried in the dryer for 10h until the water content is 3.2wt%. ;

[0087] The dry product was soaked in purified water for 24 hours and then stirred. The mass ratio of the dried attapulgite clay to purified water was 1:10; and then dispersed in a disperser with a dispersing shaft speed of 1400r / min and a dispersing disc diameter of 500mm, the dispersion time is controlled within 15 minutes; after the dispersion is completed, pass through a 300-mesh sieve to obtain a coarse material liquid;

[0088] (2) Ultrasonic disperse the crude material liquid at 20°C for 50 minutes, and the ultrasonic frequency is 35KHz to obtain a suspoemulsion; keep the upper suspoemulsion, and then re...

experiment example 1

[0095] Experimental example 1. Acute toxicity test of active attapulgite

[0096] (1) Medicine: the active attapulgite powder prepared in Example 1, ready for use.

[0097] (2) Animals: Golden hamsters are of ordinary grade, provided by the Experimental Animal Center of Shandong University.

test approach —

[0098] (3) Test method - Kou's method:

[0099] The test steps are as follows:

[0100] Pre-test

[0101] Select 80 healthy adult rats (body weight 130g-150g) and mice (body weight 18g-22g) each (half male and half male). Select 20 rats from them, divide them into four groups randomly with 5 rats in each group, and do the pre-test. The feeding doses were 500, 5000, 10000, 20000 mg / kg body weight respectively. After oral gavage for 5 days, none of the animals died.

[0102] formal test

[0103] Set up the formal test dose group: choose healthy adult rats (body weight 130g-150g), mice (body weight 18g-22g), 70 each (half male and half female), and the rats are randomly divided into five groups with 14 rats in each group, and fed respectively. The doses are 5762, 8232, 11760, 16800 and 24000 (mg / kg body weight), five dose groups. The mice were randomly divided into five groups with 14 mice in each group, and the doses were 5931, 8472, 12103, 17290 and 24700 (mg / kg body weigh...

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Abstract

The invention relates to an active attapulgite medicine and a preparation method for the same. The active attapulgite is prepared by activating attapulgite powder with 325-400 meshes for 3-5 hours in a condition of 150-260 DEG C, and 20-100% in percentage by weight within the medicine; and the ratio of the diffraction peak height of christobalite in the active attapulgite to the characteristic peak height of attapulgite is less than 50.0%. The preparation method comprises the following steps of: pre-treating attapulgite clay to obtain an attapulgite crude material liquid, and ultrasonically dispersing to obtain a suspended emulsion; and separating the suspended emulsion to remove materials having a relative density of greater than 2.3 g / cm<3>, centrifugally separating, drying, crushing until the average grain diameter is not greater than 45 microns, and activating the prepared attapulgite powder at a high temperature, thus obtaining the active attapulgite powder. The active attapulgite powder is prepared into a powder without adding pharmaceutic adjuvants, or prepared into a powder, chewable tablets, dispersible tablets, and granules with adding a conventional amount of pharmaceutic adjuvants. The content of christobalite in the active attapulgite powder disclosed by the invention meets the national medicine standards; and christobalite is good in adsorbability and wide in application range.

Description

technical field [0001] The invention relates to an active attapulgite medicine for treating digestive tract diseases such as diarrhea and flatulence and a preparation method thereof, belonging to the technical field of medicine. Background technique [0002] Diarrheal disease is a common, common and frequently-occurring disease, which is widely prevalent all over the world and seriously endangers human health. Clinically, diarrhea is a disease mainly caused by gastrointestinal dysfunction caused by viruses, bacteria, food toxins or chemical poisons, drug effects, intestinal allergies, systemic diseases and other reasons. The basis of diarrhea is that the secretion, digestion, absorption and motility of the gastrointestinal tract are impaired or disordered, resulting in increased secretion, incomplete digestion, reduced absorption or accelerated motility, etc., eventually resulting in thin stools that may contain exudate. Diarrhea due to increased stool frequency. [0003] ...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61K33/26A61P1/00A61P1/12
Inventor 乔敏杨毅娟袁武杰刘钢
Owner SHANDONG SBOND PHARMA
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