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Diammonium glycyrrhizinate enteric-coated pellet as well as preparation method and preparation thereof

A technology of diammonium glycyrrhizinate and enteric-coated pellets, applied in the field of medicine, can solve the problems of reducing drug efficacy, absorption, uneven distribution, low bioavailability, etc., to avoid damage, ensure stability, and improve bioavailability. Effect

Active Publication Date: 2013-09-18
CHENGDU HUASUN GRP INC LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because diammonium glycyrrhizinate is unstable and easy to degrade in an acidic environment, and diammonium glycyrrhizinate is easily destroyed by gastric acid in the stomach after ordinary capsules are taken, thereby reducing the efficacy of the drug, and the residence time of the drug in the body is short after taking the medicine. Problems such as uneven absorption and distribution, low bioavailability, and insignificant drug efficacy

Method used

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  • Diammonium glycyrrhizinate enteric-coated pellet as well as preparation method and preparation thereof
  • Diammonium glycyrrhizinate enteric-coated pellet as well as preparation method and preparation thereof
  • Diammonium glycyrrhizinate enteric-coated pellet as well as preparation method and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] The preparation of embodiment 1 diammonium glycyrrhizinate enteric-coated pellets

[0056] Take 100g of diammonium glycyrrhizinate and mix it with 120g of starch and 120g of microcrystalline cellulose to form a uniform powder to obtain the first product; add another 2g of starch to 100mL of boiling water to form the second product; take 5g of PVPk 30 , add 100mL ethanol aqueous solution (the volume percentage of ethanol is 30%) to prepare the third product; take 68g enteric coating material and dissolve it in 400mL water to prepare the coating liquid. Add the first product into the fluidized bed, spray into the second product, prepare and screen 35-50 mesh mother cores, place in the fluidized bed and continue to spray the first product and the third product, increase the preparation of pellets, dry, Take 20-mesh to 24-mesh pellets, put them in a fluidized bed, spray into the coating solution and coat them to prepare enteric-coated pellets, dry them, and obtain.

Embodiment 2

[0057] The preparation of embodiment 2 diammonium glycyrrhizinate enteric-coated pellets

[0058] Take 100g of diammonium glycyrrhizinate, mix it with 150g of dextrin and 150g of mannitol to form a uniform powder, and get the first product; add another 2g of dextrin to 100mL boiling water to make the second product; take 5g of hypromellose, add 100mL of ethanol aqueous solution (the volume percentage of ethanol is 30%) was prepared as the third product; 80g of enteric coating material was dissolved in 400mL of water to prepare a coating liquid. Add the first product into the fluidized bed, spray into the second product, prepare and screen 35-50 mesh mother cores, place in the fluidized bed and continue to spray the first product and the third product, increase the preparation of pellets, dry, Take 20-mesh to 24-mesh pellets, put them in a fluidized bed, spray into the coating solution and coat them to prepare enteric-coated pellets, dry them, and obtain.

Embodiment 3

[0059] The preparation of embodiment 3 diammonium glycyrrhizinate enteric-coated pellets

[0060] Take 100g of diammonium glycyrrhizinate, mix it with 400g of starch and 400g of microcrystalline cellulose to form a uniform powder, and get the first product; add another 10g of starch into 500mL of boiling water to make the second product; take 20g of PVPk 30 , add 400mL ethanol aqueous solution (the volume percentage of ethanol is 30%) to prepare the third product; take 180g enteric coating material and dissolve it in 900mL water to prepare the coating solution. Add the first product into the fluidized bed, spray into the second product, prepare and screen 35-50 mesh mother cores, place in the fluidized bed and continue to spray the first product and the third product, increase the preparation of pellets, dry, Take 20-mesh to 24-mesh pellets, put them in a fluidized bed, spray into the coating solution and coat them to prepare enteric-coated pellets, dry them, and obtain.

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Abstract

The invention relates to the technical field of medicines and in particular relates to a diammonium glycyrrhizinate enteric-coated pellet as well as a preparation method and preparation thereof. The diammonium glycyrrhizinate enteric-coated pellet comprises diammonium glycyintestinal tractrrhizinate, excipient, adhesive and coating material in a mass ratio of 1:(0.30-8):(0.02-0.1):(0.2-3.2). The diammonium glycyrrhizinate enteric-coated pellet is table in gastric juice and good in dissolution rate in intestinal tract. The damages of the gastric juice to the diammonium glycyrrhizinate are avoided, so that the stability of the diammonium glycyrrhizinate is ensured, and the biological utilization rate is improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a diammonium glycyrrhizinate enteric-coated pellet and a preparation method and preparation thereof. Background technique [0002] Hepatitis is an infectious disease that seriously threatens the health of the people. There are many medicines for treatment, but the curative effects are different. Diammonium glycyrrhizinate is the diammonium salt of glycyrrhizic acid. It is an active ingredient isolated and screened from licorice, a leguminous plant. The chemical name is: 20βcarboxy-11-oxo-n-oleanane-12-ene-3β - 2-O-β-D-glucopyranuronate-α-D-glucopyranuronate diammonium salt. As the third-generation extract of the active ingredient of traditional Chinese medicine licorice, it has strong anti-inflammatory, liver cell membrane protection and liver function improvement effects, and is widely used clinically to treat viral hepatitis and liver damage caused by physical and chemical fa...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K31/704A61P1/16
Inventor 万方杨华蓉辜勇军王莉曹科
Owner CHENGDU HUASUN GRP INC LTD
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