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Surface-common-enhanced fluorescence surface-enhanced Raman multi-layer core-shell structure composite particles and preparation method of particles

A surface-enhanced Raman, multi-layer core-shell structure technology, applied in nano-optics, nano-technology, nano-technology, etc., can solve the problem of large substrate size, and achieve the advantages of increased Raman intensity, convenient method and good aqueous solution dispersibility. Effect

Inactive Publication Date: 2013-09-11
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The above method is based on planar interference and surface co-enhanced fluorescence or Raman scattering, but due to the large size of the substrate (micron scale), it has been greatly limited in practical applications. Therefore, we propose a core in the hundreds of nanometers The method of realizing metal co-enhanced fluorescence and surface-enhanced Raman in the shell structure is mainly by embedding tens of nanometers of spherical silver nanoparticles inside the aggregated gold nanoshells with surface-enhanced Raman activity, and at the same time placing fluorescein in the Between silver and gold, metal co-enhanced fluorescence and surface-enhanced Raman scattering can be realized by adjusting the distance between them

Method used

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  • Surface-common-enhanced fluorescence surface-enhanced Raman multi-layer core-shell structure composite particles and preparation method of particles
  • Surface-common-enhanced fluorescence surface-enhanced Raman multi-layer core-shell structure composite particles and preparation method of particles
  • Surface-common-enhanced fluorescence surface-enhanced Raman multi-layer core-shell structure composite particles and preparation method of particles

Examples

Experimental program
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Effect test

Embodiment 1

[0024] Example 1. Preparation of a composite particle with a multilayer core-shell structure of surface co-enhanced fluorescence and surface enhanced Raman

[0025] (1) Dissolve 2.5 g of polyvinylpyrrolidone in 200 mL of ethylene glycol, add 0.5 g of silver nitrate, and then o Reflux for 1 h at C, then cool down to room temperature, pour into 1 L of acetone for precipitation, and centrifuge to obtain silver nanoparticles;

[0026] (2) Disperse 0.2 g of silver nanoparticles obtained in step (1) in 160 mL of ethanol, 40 mL of water and 2 mL of ammonia solution, sonicate for 1–2 h, and add 18–100 μL of ethyl orthosilicate under stirring conditions. After reacting at room temperature for 6 h, centrifuge, wash with ethanol and water three times, and then disperse in 100 mL of ethanol, in which 18 μL tetraethyl orthosilicate corresponds to a silicon layer of 3 nm, and 100 μL tetraethyl orthosilicate corresponding to a silicon layer of 15 nm;

[0027] (3) Add 8 mg of fluorescein isot...

Embodiment 2

[0032] Example 2. Preparation of composite particles with multilayer core-shell structure of surface co-enhanced fluorescence and surface enhanced Raman

[0033] In Example 1, "2.5 g polyvinylpyrrolidone" was changed to "4 g polyvinylpyrrolidone", and other preparation conditions were the same as in Example 1 to obtain a product similar to Example 1.

Embodiment 3

[0034] Example 3. Preparation of composite particles with multilayer core-shell structure with surface co-enhanced fluorescence and surface enhanced Raman.

[0035] In Example 1, "react at room temperature under a nitrogen atmosphere for 24 hours" was changed to "react at room temperature under a nitrogen atmosphere for 12 hours", and other preparation conditions were the same as in Example 1 to obtain a product similar to Example 1.

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Abstract

The invention belongs to the field of nano material preparation and provides a method to achieve surface-common-enhanced fluorescence and surface-enhanced Raman in a core-shell structure. Spherical silver nano particles are used as substrates of surface-common-enhanced fluorescence and surface-enhanced Raman, the silver nano particles are placed inside the shell layers, with good surface-enhanced Raman activity, of gold nano particles, fluorescent dye molecules are disposed between the silver nano particles and the gold nano particles, and the distances among the silver nano particles, the fluorescent dye molecules and the gold nano particles to achieve surface-common-enhanced fluorescence and surface-enhanced Raman in the core-shell structure. A Stober method is used to change corresponding experiment parameters, silicon dioxide of different thicknesses is wrapped on the surfaces of the silver nano particles to adjusting the distances among the silver nano particles, the fluorescent dye molecules and the gold nano particles, surface-common-enhanced fluorescence and surface-enhanced Raman signals of the manufactured multi-layer core-shell structure composite particles are further enhanced, and the multi-layer core-shell structure composite particles are good in water solubility, uniform and stable in nature, and promising in potential application prospect in fields such as biological imaging, safety detection and catalyzing. The method is wide in raw material source, simple and easy to operate, easy in batch and large-scale production, good in industrial production foundation, and promising in application prospect.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation. The surface of silver nanoparticles is coated with silicon dioxide of different thicknesses by the Stober method to adjust the distance between fluorescent dyes and gold nanoparticles with surface-enhanced Raman activity, and obtain a Composite particles with a multilayer core-shell structure that enhance fluorescence and surface-enhanced Raman. Background technique [0002] In recent years, plasmonic nanostructures have been widely used in solar cells, photocatalysis, spectrum-based immunoassays, and data storage. When local surface plasmons resonate with incident light, the electric field of plasmonic nanostructures is greatly enhanced, and at the same time increases The interaction between molecules and light on the surface of the nanostructure is realized, resulting in surface-enhanced fluorescence and surface-enhanced Raman. Surface-enhanced fluorescence can enhance light s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F1/02B22F9/24B82Y40/00B82Y20/00
Inventor 刘勇武培怡
Owner FUDAN UNIV
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