Compound acetylisovalery tylosin tartrate pellet and preparation method thereof
A technology of tyvanectin and tartaric acid, which is applied in the direction of pharmaceutical formulations, antibacterial drugs, and medical preparations containing active ingredients, etc., which can solve the problem of increasing the number of administrations, increasing the labor intensity, low bioavailability of drugs, and not reaching the ideal Effectiveness and other issues, to achieve the effect of masking bad smell, prolonging the drug action time, and reducing labor intensity
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Embodiment 1
[0031] A compound tyvalomectin tartrate pellet, comprising a coating and a drug-loaded core, the drug-loaded core is a microparticle with a size not greater than 30 mesh, wherein the drug-loaded core contains the following components in weight percentage: 2%; sulfamethazine 2%; lactose 10%; corncob flour 10%; starch 58%; microcrystalline cellulose 15%; granulation binder 3%.
[0032] Wherein, the granulation binder is a gelatin binder. The coating weight is 2% of the total weight of the compound tyvalectin tartrate pellets, wherein the coating material is hydroxypropyl methylcellulose.
[0033] The preparation method of described compound tyvalactin tartrate pellets comprises the following specific steps:
[0034] 1) Weigh the following components according to the following weight percentages: 2% tyvalectin tartrate, 2% sulfamethazine, 10% lactose, 10% corncob powder, 58% starch, 15% microcrystalline cellulose %, gelatin granulation binder 3%. Mix tyvalactin tartrate, sulfa...
Embodiment 2
[0039] A compound tyvalomectin tartrate pellet, comprising a coating and a drug-loaded core, the drug-loaded core is a microparticle with a size not greater than 30 mesh, wherein the drug-loaded core contains the following components in weight percentage: 5%, sulfamethazine 5%, lactose 15%, corn cob flour 10%, starch 44%, microcrystalline cellulose 15%, granulation binder 6%.
[0040] Wherein, the granulation binder is a starch binder. The coating weight is 3% of the total weight of the compound tyvalactin tartrate pellets, wherein the coating material is methyl cellulose.
[0041] The preparation method of described compound tyvalactin tartrate pellets comprises the following specific steps:
[0042] 1) Weigh the following components according to the following weight percentages: 5% tyvalectin tartrate, 5% sulfamethazine, 15% lactose, 10% corncob powder, 44% starch, 15% microcrystalline cellulose %, starch binder 6%. Mix tyvalactin tartrate, sulfamethazine, lactose, cornco...
Embodiment 3
[0047] A compound tyvalomectin tartrate pellet, comprising a coating and a drug-loaded core, the drug-loaded core is a microparticle with a size not greater than 30 mesh, wherein the drug-loaded core contains the following components in weight percentage: 10%, sulfamethazine 10%, lactose 10%; corn cob flour 15%, starch 31%, microcrystalline cellulose 20%, granulation binder 4%.
[0048] Wherein, the granulation binder is a mixture of polyvinylpyrrolidone and polyethylene glycol. The coating weight is 3% of the total weight of the compound tyvalectin tartrate pellets, wherein the coating material is hydroxypropyl methylcellulose.
[0049] The preparation method of described compound tyvalactin tartrate pellets comprises the following specific steps:
[0050] 1) Weigh the following components according to the following weight percentages: 10% tyvalectin tartrate, 10% sulfamethazine, 10% lactose, 15% corncob powder, 31% starch, 20% microcrystalline cellulose %, polyvinylpyrroli...
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