Method for stabilizing product quality of sodium bicarbonate injection

Abstract

The invention discloses a method for stabilizing the product quality of a sodium bicarbonate injection. The method is simple in operation and novel in conception. A layer of an isolation bag is packed in the position of an infusion bottle or an infusion soft bag again; the space between two packing layers is filled with carbon dioxide; experiments show that carbon dioxide in the infusion bottle or the infusion soft bag can be effectively prevented from permeating, the concentration of carbon dioxide in a liquid plastic bottle is guaranteed, and the pH value of the sodium bicarbonate injection is stabilized, so that the product quality is guaranteed. During the use, an antioxygen packing bag is removed, and the infusion bottle or the infusion soft bag is taken out and can be used. Meanwhile, a compression space (lower cavity) is formed at the bottom of the antioxygen packing bag, so that the space can be used for balancing pressure when pressure of an upper cavity changes, pressure balance in an infusion process is guaranteed, and situations such as fractures and the like can be avoided.

Description

Technical field [0001] The invention belongs to the technical field of injections, and relates to a method for stabilizing the quality of sodium bicarbonate injection products, in particular to a packaging structure and packaging method for sodium bicarbonate injection. Background technique [0002] Sodium bicarbonate injection enters the blood circulation directly after intravenous drip. Sodium bicarbonate in the blood is filtered by the glomerulus and excreted in the urine. Treatment of metabolic acidosis, treatment of mild to moderate metabolic acidosis, oral administration is appropriate. Severe metabolic acidosis should be given intravenously, such as severe kidney disease, circulatory failure, cardiopulmonary resuscitation, cardiopulmonary bypass, severe primary lactic acidosis, diabetic ketoacidosis, etc. There are also alkalization of urine, as an antacid and intravenous drip, which have non-specific therapeutic effects on certain drug poisonings. [0003] At present, th...

AI Technical Summary

Problems solved by technology

Glass infusion bottles have disadvantages such as heavy weight, inconvenient transportation, easy damage, and easy to be corroded by sodium bicarbonate to cause peeling off, so they are not suitable for packaging alkaline injections such as sodium bicarbonate injection.

Polypropylene infusion bottles and multi-layer co-extruded infusion bags do not have the disadvantages of glass infusion bottles, but due to the influence of materials, they are permeable to oxygen, nitrogen or carbon dioxide, so that the packaged products are in contact with oxygen, nitrogen or carbon dioxide. The risk of loss, especially for sodium bicarbonate injection, the carbon dioxide in it is easy to cause loss, it is difficult to stabilize the pH value of sodium bicarbonate injection, and there is a risk of product quality change

Images