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Application of letrozole (LE) in preparation of drug used for inducing follicular development of calf by hormone

A technology of follicle development and letrozole, which is applied in hormone-induced calf follicle development. The application field of letrozole in the preparation of hormone-induced calf follicle development medicine can solve the problems that there are no application reports on improvement, and achieve accelerated Improved breed selection and multiplication technology system, lower estrogen level, and promote the effect of follicle development

Active Publication Date: 2014-07-02
CHINA AGRI UNIV
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Problems solved by technology

A large number of studies have shown that the combined use of LE and FSH improves the efficiency of superovulation. It is a new type of ovulation induction drug and has been widely used in human ovulation induction therapy and experimental animal research. Improvements have not yet been reported in application

Method used

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  • Application of letrozole (LE) in preparation of drug used for inducing follicular development of calf by hormone

Examples

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Embodiment 1

[0022] In this example, a better hormone induction scheme using FSH proved in practice was adopted, and LE was administered at the same time, and the optimal dose of LE for inducing follicle development in calves was determined by oral administration of different doses of LE. Calves were inserted vaginal suppositories (CIDR) at 8:00 am on the 0th day, and were taken out 12 hours after the last FSH injection on the 8th day; FSH was injected on the 6th day, and FSH was injected continuously for 2 days, twice a day at 8:00 am , 8:00 p.m.; 24 hours after the first FSH injection, that is, different doses of LE were used in the third FSH injection.

[0023] In this embodiment, the number of ovarian follicles was observed after induction with FSH and LE, and then the oocytes were collected. After the oocytes were collected, they were cultured in vitro, and the embryos developed to the blastocyst stage 7 days after fertilization. They were implanted into adult recipient cattle with ob...

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Abstract

The invention provides an application of letrozole (LE) in preparation of a drug used for inducing follicular development of a calf by hormone. According to the invention, influence of LE on internal secretion and paracrine and an ovary follicle collecting effect are utilized, FSH (follicle-stimulating hormone) is used in the conventional hormone inducing method while LE is combined, follicular development of the calf is promoted, ovocyte acquisition efficiency is improved, abundant germplasm resources before a follicle of a fine calf is locked are fully excavated, fine calf breeding and a propagation expanding technology system is sped up, and breeding efficiency and technological level are greatly improved.

Description

technical field [0001] The present invention relates to a novel hormone-induced calf follicle development method, in particular to the application of letrozole in the preparation of hormone-induced calf follicle development medicines, which can be used to produce transgenic clones using oocytes collected after hormone induction Livestock, livestock breeding and protection of endangered species. The invention belongs to the field of applied embryo biotechnology. Background technique [0002] The theoretical basis of hormone-induced follicle development in calves comes from superovulation technology in adult cows, that is, exogenous gonadotropin is used to treat calves to induce ovarian follicle development, increase the number of available oocytes, and combine live oocyte collection technology to produce in vitro Embryos with high developmental ability were implanted into estrous adult recipient cows through embryo transfer technology, and successfully experienced full devel...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4196A61P15/08
Inventor 田见晖贾振伟吴中红张家新安磊
Owner CHINA AGRI UNIV
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