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Production method of three-dimensional porous composite bar

A three-dimensional porous, composite rod technology, applied in medical science, prosthesis, etc., can solve the problems of uneven dispersion of pores and poor mechanical properties, and achieve good biocompatibility, low cost, thermal stability and improved mechanical properties Effect

Inactive Publication Date: 2014-08-20
SOUTHWEAT UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So as to effectively solve the shortcomings of hydroxyapatite composite bone repair scaffold materials in the current technology such as uneven dispersion of pores and poor mechanical properties

Method used

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  • Production method of three-dimensional porous composite bar
  • Production method of three-dimensional porous composite bar
  • Production method of three-dimensional porous composite bar

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The graphene oxide powder was added to 250 mL of deionized water solution, and ultrasonically stirred for 1 hour to obtain a graphene oxide solution with a concentration of 1 mg / mL. Calcium nitrate and potassium dihydrogen phosphate are added to the graphene oxide solution according to the calcium ion concentration of 0.4kg / L and the phosphorus ion concentration of 0.18kg / L, and stirred evenly to obtain a graphene oxide hydroxyapatite precursor solution, while 7.5 g of konjac glucomannan was added while stirring to obtain a mixed solution, which was stirred at a constant temperature of 45° C. for 30 minutes, and stood for deaeration for 24 hours. The above solution was injected into a dialysis bag, sealed with a dialysis bag clip, and penetrated into an alkaline coagulation solution with a mass concentration of 1.5%, soaked at a constant temperature of 60 ° C for 7 days to obtain graphene oxide modified konjac glucomannan / hydroxyapatite Stone three-dimensional porous co...

Embodiment 2

[0027] The graphene oxide powder was added to 250 mL of deionized aqueous solution, and ultrasonically stirred for 0.5 hours to obtain a graphene oxide solution with a concentration of 1 mg / mL. Calcium nitrate and potassium dihydrogen phosphate are added to the graphene oxide solution according to the calcium ion concentration of 1.6kg / L and the phosphorus ion concentration of 0.72kg / L, and stirred evenly to obtain the graphene oxide hydroxyapatite precursor solution. 7.5 g of konjac glucomannan was added while stirring to obtain a mixed solution, which was stirred at a constant temperature of 45° C. for 30 minutes, and stood for deaeration for 24 hours. The above solution was injected into a dialysis bag, sealed with a dialysis bag clip, and penetrated into an alkaline coagulation solution with a mass concentration of 1.5%, soaked at a constant temperature of 60 ° C for 7 days to obtain graphene oxide modified konjac glucomannan / hydroxyapatite Stone three-dimensional porous c...

Embodiment 3

[0030] The graphene oxide powder was added to 250 mL of deionized aqueous solution, and ultrasonically stirred for 0.6 hours to obtain a graphene oxide solution with a concentration of 5 mg / mL. Calcium nitrate and potassium dihydrogen phosphate are added to the graphene oxide solution according to the calcium ion concentration of 1.6kg / L and the phosphorus ion concentration of 0.72kg / L, and stirred evenly to obtain the graphene oxide hydroxyapatite precursor solution. 10 g of konjac glucomannan was added while stirring to obtain a mixed solution, which was stirred at a constant temperature of 45° C. for 30 minutes, and then left to stand for deaeration for 24 hours. The above solution was injected into a dialysis bag, sealed with a dialysis bag clip, and penetrated into an alkaline coagulation solution with a mass concentration of 1.5%, soaked at a constant temperature of 60 ° C for 7 days to obtain graphene oxide modified konjac glucomannan / hydroxyapatite Stone three-dimensio...

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Abstract

The invention discloses a production method of a three-dimensional porous composite bar. The method is characterized by comprising the following steps of: preparing a graphene oxide solution; adding calcium salt and phosphate into the graphene oxide aqueous solution to be uniformly stirred, thus obtaining a graphene oxide / hydroxyapatite precursor solution; and adding konjac glucomannan into the graphene oxide / hydroxyapatite precursor solution under stirring, stirring the solution for 10-120 minutes at 35-60 DEG C, standing, filling the obtained mixed solution into a dialysis bag, soaking the sealed dialysis bag into alkaline solidification liquid, soaking the dialysis bag for 5-15 days at 40-60 DEG C, soaking materials in the dialysis bag in deionized water, cleaning and drying the materials, freezing the materials at a super low temperature and performing vacuum freeze drying on the materials to obtain the three-dimensional porous composite bar. The mechanical property and porosity of the produced composite bar can meet the clinical use requirements of bone repair scaffold materials, and the composite bar can effectively promote bone tissues to quickly and spontaneously repair defects and has a good effect.

Description

technical field [0001] The invention belongs to the preparation of a polymer composite rod, and relates to a preparation method of a graphene oxide reinforced modified konjac glucomannan / hydroxyapatite three-dimensional porous composite rod. The mechanical properties and porosity of the prepared three-dimensional porous composite rod can meet the clinical use requirements of the bone repair scaffold material, and are especially suitable for the bone repair scaffold material. Background technique [0002] Graphene oxide is an important derivative of graphene, also known as functionalized graphene. Its structure is roughly the same as that of graphene, except that some functional groups, mainly oxygen-containing functional groups, are attached to the two-dimensional base. , many active functional groups such as hydroxyl, carboxyl, epoxy and carbonyl, where hydroxyl and epoxy functional groups are mainly located on the basal plane of graphite, while carboxyl, oxygen and carbony...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/20A61L27/12A61L27/08A61L27/56
Inventor 竹文坤段涛雷佳吴凡秦韬
Owner SOUTHWEAT UNIV OF SCI & TECH
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