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Propolis flavonoid extractive and preparation method thereof

The technology of extract and total flavonoids is applied in the field of propolis total flavonoids extract and its preparation, which can solve the problems of expensive supercritical extraction machine, increase the difficulty of separation and purification, low extraction efficiency, etc., and achieve stable and controllable quality and remarkable economical efficiency. and social benefits, the effect of shortening the extraction time

Active Publication Date: 2013-04-24
达仁堂(天津)中药饮片有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The ethanol extraction method is simple to operate, but the extraction efficiency is not high and the production cycle is long
Supercritical CO 2 The extraction method has no solvent residue and less impurities, but due to the flavonoids in the supercritical fluid CO 2 The solubility in is very low, so it is necessary to add entrainer to increase the solubility, which makes the extract obtained by extraction mixed with entrainer
Moreover, the supercritical extraction machine is expensive, the cost is high, the production volume is small, and there is still a long distance from industrialization
The microwave extraction method has a short extraction time and an improved extraction rate, but it will produce a large amount of beeswax, which increases the difficulty of separation and purification

Method used

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  • Propolis flavonoid extractive and preparation method thereof
  • Propolis flavonoid extractive and preparation method thereof
  • Propolis flavonoid extractive and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Embodiment 1: Preparation of propolis total flavonoids extract

[0052] Take 100g of propolis, freeze the propolis at -40°C for 1 hour, crush it into fine powder, add 30 times the amount of 60% ethanol (volume percentage) to the crushed propolis, and extract it with ultra-high pressure extraction equipment, the extraction pressure is 300Mpa, the extraction time After 5 minutes, the extract was concentrated and dried under reduced pressure to obtain a dried product, which was 65 grams of propolis total flavonoids extract of the present invention.

Embodiment 2

[0053] Embodiment 2: Preparation of propolis total flavonoids extract

[0054] Take 100g of propolis, freeze the propolis at -50°C for 2 hours, crush it into fine powder, add 50 times the amount of 70% ethanol (volume percentage) to the crushed propolis, and extract it with ultra-high pressure extraction equipment, the extraction pressure is 400Mpa, the extraction time For 8 minutes, the extract was concentrated and dried under reduced pressure to obtain a dried product, which was 57 grams of propolis total flavonoids extract of the present invention.

Embodiment 3

[0055] Embodiment 3: preparation propolis total flavonoid extract

[0056] Take 100g of propolis, freeze the propolis at -60°C for 2 hours, crush it into fine powder, add 50 times the amount of 70% ethanol (volume percentage) to the crushed propolis, and extract it with ultra-high pressure extraction equipment, the extraction pressure is 500Mpa, the extraction time For 10 minutes, the extract was concentrated and dried under reduced pressure to obtain a dried product, which was 49 grams of propolis total flavonoids extract of the present invention.

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Abstract

The invention discloses a propolis flavonoid extractive and a preparation method thereof, which belong to the field of traditional Chinese medicine modernization. According to the technical scheme, the preparation method comprises the following steps of: freezing propolis at -40 DEG C to -80 DEG C, and crushing the frozen propolis; adding alcohol into the crushed propolis, and performing extraction on the crushed propolis by an ultra-high-pressure extraction device, and concentrating and drying an extracting solution, thereby obtaining the propolis flavonoid extractive. The propolis flavonoid extractive and the preparation method provided by the invention have the advantages that the yield of propolis flavonoids is high; the extractive liquid is clear and is easy to filter; and the preparation method is simple to implement, and is suitable for industrial mass production.

Description

technical field [0001] The invention relates to a propolis total flavonoid extract and a preparation method thereof, belonging to the field of traditional Chinese medicine modernization. Background technique [0002] Propolis is a colloidal solid with an aromatic smell that is processed by bees from the resin (gum) collected from plant spores or tree trunks, mixed with the secretions of their palate glands and wax glands. As a health food, propolis mainly has the effect of immune regulation. There are also health functions such as auxiliary anti-oxidation, regulation of blood lipids, blood pressure, blood sugar, and auxiliary protection of gastric mucosa. Propolis contains flavonoids, terpenes, phenolic acids and other biologically active substances. Among them, flavonoids are the main physiologically active substances in propolis. Flavonoids include flavonoids, flavonols, and dihydroflavonoids. Flavonoids have various physiological and pharmacological effects, can help ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P3/10A61P3/06A61K35/644
Inventor 张宏明牛瑞杰李文艳曹春梅
Owner 达仁堂(天津)中药饮片有限公司
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