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Aliphatic polyester double-layered asymmetric guided tissue regeneration membrane and preparation method thereof

A technology for guiding tissue regeneration and aliphatic polyester, applied in medical science, surgery, etc., can solve the problems of complex post-processing measures, difficult control of membrane pore size, low spinning and molding efficiency, etc. The effect of good interlayer bonding and simple preparation method

Active Publication Date: 2013-04-03
北京市意华健科贸有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The disadvantages of the currently disclosed method for preparing a guided tissue regeneration membrane by electrospinning are that the spinning efficiency is low, the pore size of the membrane is difficult to control, and the mechanical strength of the membrane is poor. The post-processing measures are complicated, and at the same time, the thickness of the film will be increased and its flexibility will be reduced.

Method used

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  • Aliphatic polyester double-layered asymmetric guided tissue regeneration membrane and preparation method thereof
  • Aliphatic polyester double-layered asymmetric guided tissue regeneration membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Dissolve 1.411g of racemic polylactic acid (PDLLA) with a viscosity average molecular weight of 200,000 in a mixed solvent of 9ml of chloroform and 1ml of N,N-dimethylformamide, and magnetically stir at room temperature for 12 hours to obtain a concentration of 9% (w / w) polylactic acid electrospinning solution, stand at room temperature to defoam; dissolve 2.000g of polylactic acid glycolic acid copolymer (PLGA, molar ratio 50:50) with a viscosity average molecular weight of 130,000 in 8ml tetrahydrofuran and 2mlN , In a mixed solvent of N-dimethylformamide, magnetically stirred at room temperature for 12 hours to obtain a polylactic acid glycolic acid copolymer electrospinning solution with a concentration of 0.2g / ml, and let it stand at room temperature to defoam;

[0025] 2. Add the polylactic acid electrospinning solution prepared in step 1 to the reservoir for electrospinning. The starting voltage is 15KV, the receiving distance is 15cm, and the liquid output rate i...

Embodiment 2

[0032] 1. Dissolve 1.074g of racemic polylactic acid (PDLLA) with a viscosity average molecular weight of 406,000 in a mixed solvent of 9ml of chloroform and 1ml of N,N-dimethylformamide, and magnetically stir at room temperature for 12 hours to obtain a concentration of 7% (w / w) polylactic acid electrospinning solution, defoaming at room temperature;

[0033] 2. Take 5ml of the polylactic acid electrospinning solution prepared in step 1 and add it to the reservoir for electrospinning. The spinning conditions are: voltage 15KV, receiving distance 20cm, output rate 7ml / h, receiving device with tin foil attached to the surface The rotating stainless steel disc (diameter 100mm), the disc speed is 300rpm, and the polylactic acid electrospun membrane with a diameter of 100mm and a thickness of 0.2mm is obtained;

[0034] 3. Place the polylactic acid electrospun membrane obtained in step 2 between two flat plates with fine patterns on the inner surface and the other without patterns on t...

Embodiment 3

[0040] 1. Dissolve 1.074g of racemic polylactic acid (PDLLA) with a viscosity average molecular weight of 406,000 in a mixed solvent of 9ml of chloroform and 1ml of N,N-dimethylformamide, and magnetically stir at room temperature for 12 hours to obtain a concentration of 7% (w / w) polylactic acid electrospinning solution, let stand at room temperature for defoaming; Dissolve 1.411g racemic polylactic acid (PDLLA) with a viscosity average molecular weight of 200,000 in 9ml chloroform and 1ml N,N-dimethylformaldehyde In a mixed solvent of amide, magnetically stirred at room temperature for 12 hours to obtain a polylactic acid electrospinning solution with a concentration of 9% (w / w), and let it stand at room temperature to defoam;

[0041] 2. Add the polylactic acid electrospinning solution with a concentration of 7% (w / w) prepared in step 1 to the reservoir for electrospinning. The starting voltage is 15KV, the receiving distance is 20cm, and the liquid output rate is 7ml / h. The r...

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Abstract

The invention discloses an aliphatic polyester double-layered asymmetric guided tissue regeneration membrane and a preparation method thereof. The aliphatic polyester double-layered asymmetric guided tissue regeneration membrane consists of a compact aliphatic polyester layer and a loose aliphatic polyester layer. The preparation method comprises the following steps: preparing an electrospinning liquid A and an electrospinning liquid B through aliphatic polyester; achieving electrostatic spinning film-forming through the electrospinning liquid A and obtaining the compact layer through hot-pressing; achieving electrostatic spinning film-forming on the electrospinning membrane A through the electrospinning liquid B to obtain the loose layer; achieving vacuum drying, solvent removal and freeze drying of a double-layered asymmetric electrospinning membrane; and finally achieving Co<60> radiation or ethylene epoxide sterilization of the double-layered asymmetric electrospinning membrane to obtain the double-layered asymmetric guided tissue regeneration membrane. The invention has the advantages that the preparation method is simple, the preparation efficiency is high, and the prepared membrane has favorable biocompatibility and mechanical property, appropriate degradation rate and excellent attachment property, can well satisfy the clinical requirements for guided tissue regeneration and repair, and is an ideal guided tissue regeneration membrane material.

Description

Technical field [0001] The invention relates to an aliphatic polyester double-layer asymmetric guided tissue regeneration membrane and a preparation method thereof, belonging to the field of periodontal tissue repair biomedical materials and medical equipment. Background technique [0002] In the field of dentistry, it is generally difficult to regenerate the periodontal tissue after destruction. At present, the reconstruction and regeneration of periodontal tissue is mainly treated by guided tissue regeneration surgery (GTR). The basic principle is to place a physical septum between the root surface and the gingival flap to prevent the fast-growing gingival epithelial cells and connectives. The tissue's root invasion and growth can selectively protect and promote periodontal specific cells to preferentially occupy the root surface, forming a new periodontal tissue attachment device. The ideal guided tissue regeneration membrane should have good biocompatibility, proper biodegra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06
Inventor 肖阳范丽娟姚芳莲张二帅高志忠
Owner 北京市意华健科贸有限责任公司
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