Bee venom compound with sun-proof effect
A composition and technology of bee venom, applied in the direction of drug combination, skin care preparations, cosmetics, etc., can solve the problems of skin irritation and phototoxicity, skin dependence, easy to clog pores, etc., and achieve good spreadability and reduce skin damage. Damage, no skin irritation effect
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Embodiment 1
[0037] Use a bee venom collector to collect crude wasp venom, add 25 volumes of water to fully dissolve it, centrifuge at 8000 g for 15 minutes, ultrafilter the supernatant through an ultrafiltration membrane with a molecular weight cut-off of 10000 Da, and freeze-dry the filtrate to obtain bee venom.
[0038] The bee venom composition with sunscreen effect of the present embodiment is composed of the following components according to the total mass percentage of 100%:
[0039] Phase A: 1% terephthalmethylene dicamphorsulfonic acid, 0.1% carbomer, 0.8% NaCl, 5% 1,3-butanediol, 4% propylene glycol, EDTA-2Na0.1%, deionized water margin.
[0040] Phase B: 1.5% bis-ethylhexyloxyphenol methoxyphenyl triazine, 0.3% ethylhexyl methoxycinnamate, 1% cresyl trisiloxane, micron diamond-type oily TiO 2 Dispersion liquid 9% (containing TiO 2 1.5%), fatty alcohol polyoxyethylene ether 3%, C 12 -C 15 Alkyl Benzoate 9%, Dioctyl Carbonate 2%, Microcrystalline Wax 0.8%, Azone / PEG-40 Hydroge...
Embodiment 2
[0046] The crude bee venom was collected by a bee venom collector, fully dissolved by adding 10 times the volume of water, centrifuged at 5000g for 30min, the supernatant was ultrafiltered through an ultrafiltration membrane with a molecular weight cut-off of 10000Da, and the filtrate was freeze-dried to obtain bee venom.
[0047] The bee venom composition with sunscreen effect of the present embodiment is composed of the following components according to the total mass percentage of 100%:
[0048] Phase A: 1.5% disodium salt of 2,2′-bis-(1,4-phenylene) 1H-benzimidazole-4,6-disulfonic acid, methylene bis-benzotriazolyl tetra 1% methyl butylphenol, 0.2% carbomer, 4% glycerin, 3% propylene glycol, and the balance of deionized water.
[0049] Phase B: bis-ethylhexyloxyphenol methoxyphenyl triazine 0.2%, ethylhexyl methoxycinnamate 8%, TiO 2 / Hydrated Silica / Aluminum Hydroxide / Dimethicone / Methylsiloxane Copolymer 0.5%, Ceteareth-2 1.5%, Cetearyl Ether-212%, Jojoba Oil 3 %...
Embodiment 3
[0055] Purchase wasp crude bee venom from Wuhan Yimin Bee Products Co., Ltd., add 30 times the volume of water to fully dissolve, centrifuge at 10,000 g for 10 minutes, and ultrafilter the supernatant through an ultrafiltration membrane with a molecular weight cut-off of 10,000 Da, then freeze-dry the filtrate to obtain bee venom .
[0056] Use a bee venom collector to collect crude bee venom, add 30 times the volume of water to fully dissolve, centrifuge at 10,000 g for 10 min, and ultrafilter the supernatant through an ultrafiltration membrane with a molecular weight cut-off of 10,000 Da, then freeze-dry the filtrate to obtain bee venom.
[0057] The bee venom composition with sunscreen effect of the present embodiment is composed of the following components according to the total mass percentage of 100%:
[0058] Phase A: methylenebis-benzotriazolyltetramethylbutylphenol 0.1%, terexylylenebiscamphorsulfonic acid 4.5%, phenylbenzimidazolesulfonic acid and its potassium, sodi...
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