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Preparation method of pullingqianzheng pills

A technique of coating and coating of Qianzheng Pills, which is applied in the field of preparation of Qianzheng Pills, can solve the problems affecting the application of medicine primers, affecting patient compliance, and inconvenient use, and achieves the effects of uniform size, fast onset of action, and convenient use

Active Publication Date: 2015-07-08
陕西中药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In clinical application, it is extremely inconvenient for patients to use: it is not easy to grind finely, which affects the efficacy of the medicine; when the patient has no drinking habit, it affects the application of the medicine primer; the fishy smell of the silkworm and scorpion animal medicine affects the patient's compliance

Method used

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  • Preparation method of pullingqianzheng pills
  • Preparation method of pullingqianzheng pills
  • Preparation method of pullingqianzheng pills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A preparation method of Qianzheng Pills, comprising the following steps:

[0047] 1) In terms of parts by mass, 3 parts of Aconite Radix, 3 parts of Bombyx mori and 4 parts of Scorpion are used as raw materials, and the raw materials are cleaned and removed; the scorpion is crushed and dried to the mass parts of water less than 10%;

[0048] 2) Mix Aconite fructus, Bombyx mori and crushed scorpion, crush them (or coarse powder), then crush them into very fine powder with a superfine pulverizer, and then sterilize;

[0049] 3) Mix the very fine powder of the raw material drug with the rice wine suspension at a mass ratio of 3 to 10:1 to prepare a soft material, wherein the rice wine suspension is suspended in the rice wine with a mass concentration of 5% cross-linked carboxymethyl Sodium cellulose;

[0050] 4) The soft material is molded into pills, dried at 50-60°C and then coated; after coating, dried to obtain Qianzheng pills.

Embodiment 2

[0052] A preparation method of Qianzheng Pills, comprising the following steps:

[0053] 1) In terms of parts by mass, use 3.5 parts of Aconite Radix, 3.2 parts of Bombyx mori and 5.0 parts of Scorpion as raw materials, and cleanly select and remove impurities from the raw materials; crush Scorpion and dry to water content in parts by mass less than 10%;

[0054] 2) Mix the Radix Aconiti, Bombyx japonicus and the crushed scorpion, preliminarily crush (or coarse powder), and then use a superfine pulverizer to crush into a very fine powder, pass through a 200-mesh sieve, and then cobalt 60 radiation sterilization;

[0055] 3) Mix the very fine powder of the raw material drug with the rice wine suspension at a mass ratio of 10:1 to prepare a soft material, wherein the rice wine suspension is suspended in rice wine with a mass concentration of 4.5% cross-linked carboxymethyl fiber Sodium Sulfate;

[0056] 4) The soft material is molded into pills, dried at 60-70°C and then coat...

Embodiment 3

[0058] A preparation method of Qianzheng Pills, comprising the following steps:

[0059] 1) In terms of parts by mass, 3.92 parts of Aconite Radix, 3.84 parts of Bombyx mori and 4.27 parts of Scorpion are used as the raw materials, and the raw materials are cleaned and removed; the Scorpio is crushed and dried to the mass parts of water less than 10%;

[0060] 2) Mix the Radix Aconiti, Bombyx japonicus and the crushed scorpion, preliminarily crush (or coarse powder), and then use a superfine pulverizer to crush into a very fine powder, pass through a 200-mesh sieve, and then cobalt 60 radiation sterilization;

[0061] 3) Mix the very fine powder of the raw material drug with the rice wine suspension at a mass ratio of 10:1 to prepare a soft material, wherein the rice wine suspension is suspended in rice wine with 6% cross-linked carboxymethyl fiber Sodium Sulfate;

[0062] 4) The soft material is molded into pills, dried at 70-76°C and then coated; after coating, dried to o...

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Abstract

The invention discloses a preparation method of pullingqianzheng pills, and the preparation method is characterized in that 3 to 5 parts by weight of rhizoma typhonii, 3 to 5 parts by weight of stiff silkworm and 4 to 6 parts by weight of scorpio are adopted as crude drugs, and the crude drugs are sorted to remove the impurities; the scorpio is dried after being broken; the crude drugs are shattered into fine powder through an ultrafine pulverizer to be sterilized; the ultrafine powder of the crude drugs is mixed with yellow wine suspension to prepare softwood; the softwood is prepared into pills through plastic method, and then the pills are coated after being dried under the temperature of 50 to 80DEG C; and the pills are dried after being coated to obtain the pullingqianzheng pills. Due to the adoption of the preparation method, not only can biological active ingredients of the pullingqianzheng pills be maintained, but also the toxicity of the calcium oxalate crystal which is the toxic component in the rhizome typhonii can be reduced. The prepared pullingqianzheng pills hasve the advantages of high treatment effect, small dosage, small toxicity and side effect and convenience in use.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and relates to a preparation method of Qianzheng Pills. Background technique [0002] Most of the literature and textbooks believe that Qianzheng San comes from Yang Tan’s "Yang’s Family Tibetan Prescription" in Song Dynasty, and it is composed of three herbs: Baifuzi, stiff silkworm and scorpion. In fact, as early as before the Song Dynasty, Sun Simiao's "Qian Jin Fang" in the Tang Dynasty had the "non-changing golden pill" for treating crooked mouth and eyes, using raw aconite and silkworm; Angelica dahurica and musk; Zhu Danxi's "Danxi Xinfa" in the Jin and Yuan Dynasties said: "If you have a stroke, your mouth and eyes are crooked, white monkshood, silkworm, and scorpion, use them together, divide them into equal parts, and grind them into powder. One qian, mixed with hot wine." It can be seen that this recipe matured in the Tang, Song, Jin and Yuan dynastie...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/714A61K9/28A61P25/02A61K35/64A61K35/646
Inventor 同卓斌朱爱华王四旺张芳侠张小艳杨钧
Owner 陕西中药研究所
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