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Gradient laminated porous scaffold based on microsphere selective laser sintering and preparation method thereof

A porous scaffold and gradient technology, used in prostheses, bone implants, medical science, etc., can solve the problems of low sintering accuracy and difficult to control microstructure, and achieve the effect of good osseointegration and high mechanical properties.

Active Publication Date: 2013-02-20
ASIA BIOMATERIALS WUHAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional powder-based laser sintering has the disadvantages of low sintering accuracy and difficult control of the microstructure.

Method used

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  • Gradient laminated porous scaffold based on microsphere selective laser sintering and preparation method thereof
  • Gradient laminated porous scaffold based on microsphere selective laser sintering and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Dissolve 1.0g of polycaprolactone (PCL, Mw=50000) in 15ml of dichloromethane (DCM), and then use a magnetic stirrer to fully stir until it is completely dissolved to obtain a clear solution. Then 0mg, 50mg, 100mg, 150mg, 200mg, 250mg, 300mg, 350mg, 400mg of nano-hydroxyapatite were dispersed in dichloromethane, and added to the above clear solution under stirring to obtain a white suspension. Add the above suspension into the polyvinyl alcohol (PVA) solution containing 0.1% (w / v) at a stirring speed of 600rpm, disperse into tiny droplets, keep stirring, wait until the organic solvent dichloromethane volatilizes, filter, freeze After drying, composite microspheres with a mass content of 0%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, and 40% hydroxyapatite were obtained, and the diameter of the microspheres was 150 μm. Then import the 3D computer model of the designed porous support into the computer terminal of the selective laser sintering equipment in stl file format, select th...

Embodiment 2

[0028] Dissolve 1.0g of polylactic acid (PLA, Mw=100000) in 12ml of dichloromethane (DCM), and then use a magnetic stirrer to fully stir until it is completely dissolved to obtain a clear solution. Then 0 mg, 100 mg, 200 mg, 300 mg, 400 mg of nano-hydroxyapatite were dispersed in dichloromethane, and added to the above clear solution under stirring to obtain a white suspension. Add the above suspension into the gelatin solution containing 0.15% (w / v) at a stirring speed of 600rpm, disperse into tiny droplets, keep stirring, and wait for the organic solvent to volatilize, filter, and freeze-dry to obtain 0%, 10 wt %, 20 wt %, 30 wt %, 40 wt % hydroxyapatite content of composite microspheres, with an average size of 100 μm. Then import the designed three-dimensional computer model into the computer terminal of the selective laser sintering equipment in stl file format, select the single-layer manufacturing mode, select the laser power as 10w, and the scanning rate as 1000mm / s, a...

Embodiment 3

[0030] Dissolve 1.5g of polyethylene / lactide (PLGA, Mw=80000) in 15ml of acetone (Acetone), and then use a magnetic stirrer to stir until it is completely dissolved to obtain a clear solution. Then 0mg, 50mg, 100mg, 150mg, 200mg, 250mg, 300mg, 350mg, 400mg of tricalcium phosphate were dispersed in acetone, and added to the above clear solution with stirring to obtain a white suspension. Add the above suspension into the gelatin solution containing 0.1% (w / v) at a stirring speed of 400rpm, disperse into tiny droplets, and keep stirring until the organic solvent is volatilized, filtered, and freeze-dried to obtain 0%, 5 wt %, 10 wt %, 15 wt %, 20 wt %, 25 wt %, 30 wt %, 35 wt %, 40 wt % tricalcium phosphate content of composite microspheres, the diameter of the microspheres is 300 μm. Then import the designed three-dimensional computer model into the computer terminal of the selective laser sintering equipment in stl file format, select the single-layer manufacturing mode, selec...

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Abstract

The invention relates to a gradient laminated porous scaffold based on microsphere selective laser sintering and a preparation method thereof. The scaffold is prepared by taking polymer microspheres and compound microspheres of high polymers and calcium-phosphate materials as sintering raw materials and carrying out selective laser sintering on the sintering raw materials, the contents of the calcium-phosphate materials in the scaffold are ascended in a layer by layer manner from the surface layer to the bottom layer of the scaffold, and bore diameters and porosities of the scaffold are gradually ascended. The preparation method comprises the following steps of: preparing calcium-phosphate materials / high polymer composite microspheres by a solvent evaporation method; designing a three-dimensional model of the gradient-laminated porous scaffold by computer modeling software; and realizing precise manufacturing of the gradient laminated porous scaffold by virtue of a selective laser sintering device through feeding controlling and single-layer manufacturing. The mutual communication and the gradient distribution of the scaffold are beneficial for nutrient transport and tissue penetration; and the contents of calcium-phosphate materials are in continuous gradient distribution in space, the disadvantage of interface bonding strength is effectively solved, and the biological functions of the scaffold in comprehensive defect repairing of cartilages and subchondral bones are beneficially exerted.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a preparation method of selective laser sintering of a porous scaffold, more specifically, to a porous tissue engineering scaffold used for osteocartilage tissue repair, with gradient distribution of components and contents method of preparation. Background technique [0002] Trauma, tumors, and arthritis often lead to damage to articular cartilage. Since there are no blood vessels in articular cartilage, it is difficult for chondrocytes to migrate to the damaged area, making it difficult for joints to heal after injury. Tissue engineering provides a new means to solve this clinical problem. In the process of articular cartilage repair, osseointegration is an important criterion for evaluating the repair effect. [0003] Articular cartilage (osteocartilage) has a complex structure and a natural laminated structure, which can be divided into cartilage layer, calcified cartilage...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61L27/24A61L27/20A61L27/18A61L27/12A61L27/56
Inventor 张胜民杜莹莹刘浩明
Owner ASIA BIOMATERIALS WUHAN CO LTD
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