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Method for preparing magnesium L-aspartate

A technology of magnesium aspartate and magnesium carbonate, applied in chemical instruments and methods, cyanide reaction preparation, organic compound preparation, etc., can solve the problems of difficult control, poor particle size, high production cost, etc., and reduce the cost of raw materials , Improve the safety factor and reduce the site investment

Active Publication Date: 2013-01-16
宜兴市前成生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The first method: the use of organic solvents reduces the safety factor of the production environment, and organic solvents are likely to remain in the obtained products, and the use of organic solvents for extraction will increase production costs
The second extraction method has equipment, large site investment, and high production costs; the particle size of the obtained product is poor, the moisture content is unstable, and it is difficult to control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] (1) Add water to the reaction kettle, equipped with a motor to stir, heat to a temperature of 75°C, and keep stirring. After adding L-aspartic acid, gradually add magnesium carbonate. Magnesium carbonate needs to be added slowly to prevent excessive foaming and liquid splashing Out; Wherein the quality of L-aspartic acid is 20% of water quality, the mol ratio of L-aspartic acid and magnesium carbonate is: 2:1.

[0018] After the reaction solution is clarified, take a small amount of the reaction solution and filter to remove impurities, then test the pH, and correct the pH to 7.0; decolorize and filter the reaction solution, concentrate in vacuum until supersaturated to obtain a supersaturated solution, stir the supersaturated solution and cool it to room temperature, then The material was extremely viscous, but no crystals were precipitated.

[0019] (2) Transfer the supersaturated liquid to a vacuum freeze dryer, pre-freeze at -35°C for 3 hours; then freeze-dry at -20...

Embodiment 2

[0022] (1) Add water to the reaction kettle, equipped with a motor to stir, heat to a temperature of 75°C, and keep stirring. After adding L-aspartic acid, gradually add magnesium oxide. Magnesium oxide should be added slowly to prevent excessive foaming and liquid splashing Out; Wherein the quality of L-aspartic acid is 20% of water quality, the substance ratio of L-aspartic acid and magnesium oxide is: 2:1.

[0023] After the reaction solution is clarified, take a small amount of the reaction solution and filter to remove impurities, then test the pH, and correct the pH to 7.0; decolorize and filter the reaction solution, concentrate in vacuum until supersaturated to obtain a supersaturated solution, stir the supersaturated solution and cool it to room temperature, then The material was extremely viscous, but no crystals were precipitated.

[0024] (2) Transfer the supersaturated liquid to a vacuum freeze dryer, pre-freeze at -30°C for 4 hours; then freeze dry at -25°C for 4...

Embodiment 3

[0027] (1) Add water to the reaction kettle, equipped with a motor to stir, heat to a temperature of 75°C, and keep stirring. After adding L-aspartic acid, gradually add magnesium hydroxide. Magnesium hydroxide needs to be added slowly to prevent excessive foaming The liquid splashes; wherein the quality of L-aspartic acid is 20% of the water quality, and the mass ratio of L-aspartic acid to magnesium hydroxide is: 2:1.

[0028] After the reaction solution is clarified, take a small amount of the reaction solution and filter to remove impurities, then test the pH, and correct the pH to 7.0; decolorize and filter the reaction solution, concentrate in vacuum until supersaturated to obtain a supersaturated solution, stir the supersaturated solution and cool it to room temperature, then The material was extremely viscous, but no crystals were precipitated.

[0029] (2) Transfer the supersaturated liquid to a vacuum freeze dryer, pre-freeze at -38°C for 2.5 hours; then freeze at -1...

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PUM

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Abstract

The invention provides a method for preparing magnesium L-aspartate. The method comprises the steps as follows: using any one of magnesium carbonate, magnesium oxide and magnesium hydrate, and L-asparaginic acid as raw materials; carrying out reaction with water served as the solvent and with the temperature of 70-80 DEG C; calibrating the pH (Potential of Hydrogen) of reacting liquid to reach 6.0 to 7.5 after the reaction; discoloring and filtering the reacting liquid, and concentrating until supersaturation reaches; cooling supersaturation liquid; and carrying out the methods of freeze drying and vacuum drying to directly prepare the supersaturation liquid into the finished product of magnesium L-aspartate. With the adoption of the technical scheme provided by the invention, organic solvent is not used, and therefore, the safety coefficient of production environment can be improved; the demands of the customers on the residual solvent are increased, and the nonuse of the solvent represents the general trend; and meanwhile, the nonuse of the organic solvent can greatly reduce the cost of raw material, and the cost can be reduced by about RMB5000 / ton; and furthermore, the input for the equipment and field in the scheme is low, and the input on the equipment can be reduced by about 20% and the water in the product can be controlled well.

Description

technical field [0001] The invention belongs to the field of chemical synthesis, and in particular relates to a method for preparing magnesium L-aspartate. Background technique [0002] Magnesium L-aspartate is a food additive rich in nutrition and a medical and health product with high absorption efficiency. As a drug, L-magnesium aspartate has the advantages of high bioavailability, small individual differences, long half-life, few adverse reactions, significant curative effect and the like. Due to the above advantages, L-magnesium aspartate is widely used. [0003] The preparation process of magnesium L-aspartate in the prior art uses L-aspartic acid and magnesium oxide as raw materials. Magnesium L-aspartate was synthesized by solid-liquid phase reaction. The extraction method of the synthesized magnesium L-aspartate in the existing production process is as follows: using an organic solvent to change the polarity of the solvent to precipitate the product or adopting a...

Claims

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Application Information

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IPC IPC(8): C07C229/24C07C227/18
Inventor 席日新李海涛
Owner 宜兴市前成生物有限公司
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