Application of sodium butyrate in preparation of hypoxic pulmonary hypertension control medicines
A technology of pulmonary hypertension and sodium butyrate, applied in drug combination, active ingredients of anhydride/acid/halide, cardiovascular system diseases, etc., can solve the problem of drug administration, unclear toxic and negative effects, limited effect, receptor antagonism Efficiency and use methods are not clear, to achieve the effect of prevention and treatment of hypoxic pulmonary hypertension, prevention and treatment of proliferation and hypertrophy, and low price
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Embodiment 1
[0024] Dissolve 2.2 g of sodium butyrate with a purity of more than 98% in 10 mL of normal saline to prepare a drug for preventing and treating hypoxic pulmonary hypertension.
Embodiment 2
[0026] Dissolve 3.52g of sodium butyrate with a purity of more than 98% in 10mL of normal saline to prepare a drug for the prevention and treatment of hypoxic pulmonary hypertension.
[0027] Of course, sodium butyrate can be added with corresponding pharmaceutical carriers according to clinical needs, and can exist in the form of tablets, pills, capsules, aqueous solutions and other preparations.
experiment example 1
[0029] Experimental example 1: Effect of sodium butyrate on NO secretion from hypoxic human umbilical vein endothelial cells (HUVEC) and human pulmonary artery endothelial cells (HPAEC)
[0030] Human umbilical vein endothelial cells (HUVEC, cell line) were purchased from ATCC, USA. After recovery, cells were washed twice with PBS, and complete medium (high-glucose DMEM (purchased from Gibco) containing 10% fetal bovine serum (purchased from Hyclone), penicillin and streptomycin each 100 U / ml (purchased from Gibco)) was added, and the cells were cultured in normal Incubator (CO 2 5%) for routine culture at 37°C.
[0031] Human pulmonary artery endothelial cells (HPAEC, primary cells) were purchased from Invitrogen, and complete medium (composed of medium M-200, 50× endothelial cell nutrient solution LSGS, 100 U / ml of penicillin and streptomycin) was added. Cells were cultured in an ordinary culture incubator (CO 2 5%) for routine culture at 37°C.
[0032]The above-mentio...
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